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Proteome analysis of substantia nigra and striatal tissue in the mouse MPTP model of Parkinson′s disease
Zhao, Xin1; Li, Quan1; Zhao, Lei1; Pu, XiaoPing1,2
关键词MPTP Parkinson&prime s disease substantia nigra and striatum
刊名PROTEOMICS CLINICAL APPLICATIONS
2007-12-01
DOI10.1002/prca.200700077
1期:12页:1559-1569
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]2-DIMENSIONAL GEL-ELECTROPHORESIS ; UBIQUITIN-PROTEASOME SYSTEM ; HUMAN BILIVERDIN REDUCTASE ; ALPHA-SYNUCLEIN ; POLYACRYLAMIDE-GEL ; ESCHERICHIA-COLI ; OXIDATIVE STRESS ; GENE-EXPRESSION ; PARS-COMPACTA ; PROTEINS
英文摘要

The dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) replicates many of the pathological hallmarks of Parkinson′s disease (PD) in mice via selective destruction of dopamine neurons of the substantia nigra and striatum. Although MPTP has been widely used to study downstream effects following the degeneration of dopaminergic neurons, the underlying mechanisms of MPTP action remain poorly understood. To, determine the underlying mechanisms of MPTP action at the protein level, a 2-DE-based proteomics approach was used to evaluate the changes in protein expression in substantia nigra and striatal tissue in C57BL/6 mice after MPTP administration. We identified nine proteins that were markedly altered and are likely to be involved in mitochondrial function, heat shock protein activity, and which contribute enzyme activities for energy metabolism and protein degradation.

语种英语
WOS记录号WOS:000251883100004
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67703
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
北京大学第二临床医学院_检验科
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, Natl Key Res Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Xin,Li, Quan,Zhao, Lei,et al. Proteome analysis of substantia nigra and striatal tissue in the mouse MPTP model of Parkinson′s disease[J]. PROTEOMICS CLINICAL APPLICATIONS,2007,1(12):1559-1569.
APA Zhao, Xin,Li, Quan,Zhao, Lei,&Pu, XiaoPing.(2007).Proteome analysis of substantia nigra and striatal tissue in the mouse MPTP model of Parkinson′s disease.PROTEOMICS CLINICAL APPLICATIONS,1(12),1559-1569.
MLA Zhao, Xin,et al."Proteome analysis of substantia nigra and striatal tissue in the mouse MPTP model of Parkinson′s disease".PROTEOMICS CLINICAL APPLICATIONS 1.12(2007):1559-1569.
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