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学科主题: 精神卫生
题名:
Enhanced resting-state brain activities in ADHD patients: A fMRI study
作者: Tian, Lixia2; Jiang, Tianzi1; Liang, Meng1; Zang, Yufeng1; He, Yong1; Sui, Manqiu3; Wang, Yufeng3
关键词: regional homogeneity ; low-frequency fluctuations ; resting-state activity index (RSAI) ; sensory
刊名: BRAIN & DEVELOPMENT
发表日期: 2008-05-01
DOI: 10.1016/j.braindev.2007.10.005
卷: 30, 期:5, 页:342-348
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: DEFICIT HYPERACTIVITY DISORDER ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; ANTERIOR CINGULATE CORTEX ; FUNCTIONAL CONNECTIVITY ; DEFAULT MODE ; CEREBRAL-CORTEX ; BLOOD-FLOW ; CHILDREN ; FLUCTUATIONS ; MRI
英文摘要:

Resting-state functional MRI (fMRI) could be an advantageous choice for clinical applications by virtue of its clinical convenience and non-invasiveness. Without explicit stimulus, resting-state brain activity patterns cannot be obtained using any model-driven method. In this study, we advanced a measure named resting-state activity index (RSAI) to evaluate the resting-state brain activities. Using RSAI, we first investigated the resting-state brain activity patterns in normal adolescents to test the validity of this RSAI measure. Then we compared the resting-state brain activity patterns of Attention deficit hyperactivity disorder (ADHD) patients to those of their matched controls. According to the resultant brain activity patterns, we suggest that RSAI could be an applicable measure to evaluate resting-state brain activities. As compared to the controls, the ADHD patients exhibited more significant resting-state activities in basic sensory and sensory-related cortices. This finding was in accordance with ADHD symptoms of inattention. (c) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000255526800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67704
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
3.Beijing Jiaotong Univ, Dept Biomed Engn, Sch Comp & Informat Technol, Beijing 100044, Peoples R China

Recommended Citation:
Tian, Lixia,Jiang, Tianzi,Liang, Meng,et al. Enhanced resting-state brain activities in ADHD patients: A fMRI study[J]. BRAIN & DEVELOPMENT,2008,30(5):342-348.
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