北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 呼吸和危重症医学科  > 期刊论文
学科主题: 临床医学
题名:
Inflammatory and Oxidative Stress Responses of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics
作者: Huang, Wei1,2; Wang, Guangfa3; Lu, Shou-En5,7; Kipen, Howard5,6; Wang, Yuedan10; Hu, Min1,2; Lin, Weiwei1,2; Rich, David11; Ohman-Strickland, Pamela5,7; Diehl, Scott R.9; Zhu, Ping4; Tong, Jian8; Gong, Jicheng12; Zhu, Tong1,2; Zhang, Junfeng8,12
关键词: air pollution ; inflammation ; oxidative stress ; respiratory health ; the Beijing Olympics
刊名: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
发表日期: 2012-12-01
DOI: 10.1164/rccm.201205-0850OC
卷: 186, 期:11, 页:1150-1159
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Critical Care Medicine ; Respiratory System
研究领域[WOS]: General & Internal Medicine ; Respiratory System
关键词[WOS]: EXHALED BREATH CONDENSATE ; CORONARY-ARTERY-DISEASE ; NITRIC-OXIDE ; AMBIENT AIR ; ASTHMATIC-CHILDREN ; PARTICULATE MATTER ; PM2.5 EXPOSURE ; HEART-DISEASE ; DNA-DAMAGE ; POLLUTION
英文摘要:

Rationale: Unprecedented pollution control actions during the Beijing Olympics provided a quasi-experimental opportunity to examine biologic responses to drastic changes in air pollution levels.

Objectives: To determine whether changes in levels of biomarkers reflecting pulmonary inflammation and pulmonary and systemic oxidative stress were associated with changes in air pollution levels in healthy young adults.

Methods: We measured fractional exhaled nitric oxide, a number of exhaled breath condensate markers (H+, nitrite, nitrate, and 8-isoprostane), and urinary 8-hydroxy-2-deoxyguanosine in 125 participants twice in each of the pre- (high pollution), during(low pollution), and post-Olympic (high pollution) periods. We measured concentrations of air pollutants near where the participants lived and worked. We used mixed-effects models to estimate changes in biomarker levels across the three periods and to examine whether changes in biomarker levels were associated with changes in pollutant concentrations, adjusting for meteorologic parameters.

Measurements and Main Results: From the pre- to the during-Olympic period, we observed significant and often large decreases (ranging from -4.5% to -72.5%) in levels of all the biomarkers. From the during-Olympic to the post-Olympic period, we observed significant and larger increases (48-360%) in levels of these same biomarkers. Moreover, increased pollutant concentrations were consistently associated with statistically significant increases in biomarker levels.

Conclusions: These findings support the important role of oxidative stress and that of pulmonary inflammation in mediating air pollution health effects. The findings demonstrate the utility of novel and noninvasive biomarkers in the general population consisting largely of healthy individuals.

语种: 英语
所属项目编号: 1R01ES015864 ; P30ES005022 ; 5P30ES007048 ; 4760-RPFA05-3 ; 20637020 ; 2008AA062503 ; 201009032
项目资助者: NIEHS ; Health Effects Institute ; China National Science Foundation ; Chinese Ministry of Science and Technology ; Chinese Ministry of Environmental Protection
WOS记录号: WOS:000312040600020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67709
Appears in Collections:北京大学第一临床医学院_呼吸和危重症医学科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Coll Environm Sci & Engn, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Environm & Hlth, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Pulm Med, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Dept Hematol, Beijing 100871, Peoples R China
5.Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Environm & Occupat Med, Piscataway, NJ 08854 USA
6.Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854 USA
7.Univ Med & Dent New Jersey, Sch Publ Hlth, Dept Biostat, Piscataway, NJ 08854 USA
8.Univ Med & Dent New Jersey, Sch Publ Hlth, Dept Environm Hlth, Piscataway, NJ 08854 USA
9.Univ Med & Dent New Jersey, Sch Dent, Ctr Pharmacogen & Complex Dis, Piscataway, NJ 08854 USA
10.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100871, Peoples R China
11.Univ Rochester, Sch Med & Dent, Dept Community & Prevent Med, Rochester, NY USA
12.Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

Recommended Citation:
Huang, Wei,Wang, Guangfa,Lu, Shou-En,et al. Inflammatory and Oxidative Stress Responses of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,2012,186(11):1150-1159.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Huang, Wei]'s Articles
[Wang, Guangfa]'s Articles
[Lu, Shou-En]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Huang, Wei]‘s Articles
[Wang, Guangfa]‘s Articles
[Lu, Shou-En]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace