学科主题临床医学
Inflammatory and Oxidative Stress Responses of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics
Huang, Wei1,2; Wang, Guangfa3; Lu, Shou-En5,7; Kipen, Howard5,6; Wang, Yuedan10; Hu, Min1,2; Lin, Weiwei1,2; Rich, David11; Ohman-Strickland, Pamela5,7; Diehl, Scott R.9; Zhu, Ping4; Tong, Jian8; Gong, Jicheng12; Zhu, Tong1,2; Zhang, Junfeng8,12
关键词air pollution inflammation oxidative stress respiratory health the Beijing Olympics
刊名AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
2012-12-01
DOI10.1164/rccm.201205-0850OC
186期:11页:1150-1159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Critical Care Medicine ; Respiratory System
研究领域[WOS]General & Internal Medicine ; Respiratory System
关键词[WOS]EXHALED BREATH CONDENSATE ; CORONARY-ARTERY-DISEASE ; NITRIC-OXIDE ; AMBIENT AIR ; ASTHMATIC-CHILDREN ; PARTICULATE MATTER ; PM2.5 EXPOSURE ; HEART-DISEASE ; DNA-DAMAGE ; POLLUTION
英文摘要

Rationale: Unprecedented pollution control actions during the Beijing Olympics provided a quasi-experimental opportunity to examine biologic responses to drastic changes in air pollution levels.

Objectives: To determine whether changes in levels of biomarkers reflecting pulmonary inflammation and pulmonary and systemic oxidative stress were associated with changes in air pollution levels in healthy young adults.

Methods: We measured fractional exhaled nitric oxide, a number of exhaled breath condensate markers (H+, nitrite, nitrate, and 8-isoprostane), and urinary 8-hydroxy-2-deoxyguanosine in 125 participants twice in each of the pre- (high pollution), during(low pollution), and post-Olympic (high pollution) periods. We measured concentrations of air pollutants near where the participants lived and worked. We used mixed-effects models to estimate changes in biomarker levels across the three periods and to examine whether changes in biomarker levels were associated with changes in pollutant concentrations, adjusting for meteorologic parameters.

Measurements and Main Results: From the pre- to the during-Olympic period, we observed significant and often large decreases (ranging from -4.5% to -72.5%) in levels of all the biomarkers. From the during-Olympic to the post-Olympic period, we observed significant and larger increases (48-360%) in levels of these same biomarkers. Moreover, increased pollutant concentrations were consistently associated with statistically significant increases in biomarker levels.

Conclusions: These findings support the important role of oxidative stress and that of pulmonary inflammation in mediating air pollution health effects. The findings demonstrate the utility of novel and noninvasive biomarkers in the general population consisting largely of healthy individuals.

语种英语
WOS记录号WOS:000312040600020
项目编号1R01ES015864 ; P30ES005022 ; 5P30ES007048 ; 4760-RPFA05-3 ; 20637020 ; 2008AA062503 ; 201009032
资助机构NIEHS ; Health Effects Institute ; China National Science Foundation ; Chinese Ministry of Science and Technology ; Chinese Ministry of Environmental Protection
引用统计
被引频次:89[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67709
专题北京大学第一临床医学院_呼吸和危重症医学科
北京大学基础医学院
北京大学第一临床医学院_呼吸科
作者单位1.Peking Univ, Coll Environm Sci & Engn, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Environm & Hlth, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Pulm Med, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Dept Hematol, Beijing 100871, Peoples R China
5.Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Environm & Occupat Med, Piscataway, NJ 08854 USA
6.Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854 USA
7.Univ Med & Dent New Jersey, Sch Publ Hlth, Dept Biostat, Piscataway, NJ 08854 USA
8.Univ Med & Dent New Jersey, Sch Publ Hlth, Dept Environm Hlth, Piscataway, NJ 08854 USA
9.Univ Med & Dent New Jersey, Sch Dent, Ctr Pharmacogen & Complex Dis, Piscataway, NJ 08854 USA
10.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100871, Peoples R China
11.Univ Rochester, Sch Med & Dent, Dept Community & Prevent Med, Rochester, NY USA
12.Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
推荐引用方式
GB/T 7714
Huang, Wei,Wang, Guangfa,Lu, Shou-En,et al. Inflammatory and Oxidative Stress Responses of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,2012,186(11):1150-1159.
APA Huang, Wei.,Wang, Guangfa.,Lu, Shou-En.,Kipen, Howard.,Wang, Yuedan.,...&Zhang, Junfeng.(2012).Inflammatory and Oxidative Stress Responses of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics.AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE,186(11),1150-1159.
MLA Huang, Wei,et al."Inflammatory and Oxidative Stress Responses of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics".AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 186.11(2012):1150-1159.
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