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学科主题: 药学
题名:
Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals
作者: Ying, Xue2; Wen, He2; Lu, Wan-Liang1,2; Du, Ju2; Guo, Jia2; Tian, Wei2; Men, Ying2; Zhang, Yan2; Li, Ruo-Jing2; Yang, Ting-Yuan2; Shang, De-Wei2; Lou, Jin-Ning3; Zhang, Liang-Ren2; Zhang, Qiang2
关键词: Dual-targeting ; Daunorubicin liposomes modified with MAN and TF ; Blood-brain barrier ; Brain glioma-bearing rats ; Survival
刊名: JOURNAL OF CONTROLLED RELEASE
发表日期: 2010-01-25
DOI: 10.1016/j.jconrel.2009.09.020
卷: 141, 期:2, 页:183-192
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: IN-VITRO ; DRUG-DELIVERY ; TRANSFERRIN-RECEPTOR ; SOLID TUMORS ; BARRIER ; NANOPARTICLES ; TRANSPORT ; CANCER ; GROWTH ; CELLS
英文摘要:

Chemotherapy for brain glioma has been of limited value due to the inability of transport of drug across the blood-brain barrier (BBB) and poor penetration of drug into the tumor. For overcoming these hurdles, the dual-targeting daunorubicin liposomes were developed by conjugating with p-aminophenyl-alpha-D-mannopyranoside (MAN) and transferrin (TF) for transporting drug across the BBB and then targeting brain glioma. The dual-targeting effects were evaluated on the BBB model in vitro, C6 glioma cells in vitro, avascular C6 glioma tumor spheroids in vitro, and C6 glioma-bearing rats in vivo, respectively. After applying dual-targeting daunorubicin liposomes, the transport ratio across the BBB model was significantly increased up to 24.9%. The most significant uptake by C6 glioma was evidenced by flow cytometry and confocal microscope. The C6 glioma spheroid volume ratio was significantly lowered to 54.7%. The inhibitory rate to C6 glioma cells after crossing the BBB was significantly enhanced up to 64.0%. The median survival time of tumor bearing rats after administering dual-targeting daunorubicin liposomes (22 days) was significantly longer than that after giving free daunorubicin (17 days, P = 0.001) or other controls. In conclusion, the dual-targeting daunorubicin liposomes are able to improve the therapeutic efficacy of brain glioma in vitro and in animals. (C) 2009 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2007CB935801 ; 30772664 ; 20070001741
项目资助者: National Basic Research Program of China (973 program) ; National Science Foundation of China ; Education Ministry of China
WOS记录号: WOS:000274673300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67714
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.China Japan Friendship Hosp, Minist Hlth, Inst Clin Med Sci, Beijing, Peoples R China

Recommended Citation:
Ying, Xue,Wen, He,Lu, Wan-Liang,et al. Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals[J]. JOURNAL OF CONTROLLED RELEASE,2010,141(2):183-192.
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