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学科主题: 基础医学
题名:
2-(2-Nitrophenyl) propyl: a rapidly released photolabile COOH-protecting group for solid-phase peptide synthesis
作者: Wang, Gang1,2; Peng, Tao2; Zhang, Shouguo2; Wang, Junyi3; Wen, Xiaoxue2; Yan, Haiyan2; Hu, Liming1; Wang, Lin1,2
刊名: RSC ADVANCES
发表日期: 2015
DOI: 10.1039/c5ra01210d
卷: 5, 期:36, 页:28344-28348
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: CYCLIC-PEPTIDES ; NUCLEOSIDES ; PHOTOLYSIS ; SEEDS ; ACIDS
英文摘要:

We developed a new efficient photolabile protecting group, 2-(2-nitrophenyl) propyl (Npp) that blocks the carboxyl group in peptide synthesis. The Npp group is quite compatible with the Fmoc-t-Bu strategy and can be removed rapidly and quantitatively by irradiation with UV light. Using this method, we prepared a head-to-tail cycloheptapeptide.

语种: 英语
所属项目编号: 81273431 ; 81072531 ; 30770655 ; 21102176
项目资助者: National Science Foundation of China
WOS记录号: WOS:000351870500042
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67719
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
3.Beijing Inst Radiat Med, Beijing 100850, Peoples R China

Recommended Citation:
Wang, Gang,Peng, Tao,Zhang, Shouguo,et al. 2-(2-Nitrophenyl) propyl: a rapidly released photolabile COOH-protecting group for solid-phase peptide synthesis[J]. RSC ADVANCES,2015,5(36):28344-28348.
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