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学科主题: 药学
题名:
Novel approach to the synthesis of AZT 5 ′-O-hydrogen phospholipids
作者: Xiao, Q; Sun, J; Ju, Y; Zhao, YF; Cui, YX
关键词: phosphorylation ; transesterification ; H-phosphonate ; AZT ; phospholipid
刊名: TETRAHEDRON LETTERS
发表日期: 2002-07-22
卷: 43, 期:30, 页:5281-5283
收录类别: IC ; CCR ; SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ARYL H-PHOSPHONATES ; GENERAL-METHOD ; MONOESTERS ; PRODRUGS
英文摘要:

A series of AZT 5′-O-hydrogen phospholipids were synthesized by a tandem transesterification of diphenyl phosphite with AZT and a long-chain alcohol. The method possesses the merits of case of operation and high yields. It can also be extended to synthesize other biological phospholipids. (C) 2002 Elsevier Science Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000176727200017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67720
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Tsing Hua Univ, Dept Chem, Sch Life Sci & Engn, Minist Educ,Key Lab Bioorgan Phosphorus Chem, Beijing 100084, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Natl Res Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Xiao, Q,Sun, J,Ju, Y,et al. Novel approach to the synthesis of AZT 5 ′-O-hydrogen phospholipids[J]. TETRAHEDRON LETTERS,2002,43(30):5281-5283.
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