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Three-dimensional structure of HIV-1VIF constructed by comparative modeling and the function characterization analyzed by molecular dynamics simulation
Lv, Wei; Liu, Zhenming; Jin, Hongwei; Yu, Xianghui; Zhang, Liangren; Zhang, Lihe
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
2007
DOI10.1039/b612050d
5期:4页:617-626
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]HUMAN-IMMUNODEFICIENCY-VIRUS ; PROTEIN SECONDARY STRUCTURE ; UBIQUITIN LIGASE COMPLEX ; VIF PROTEIN ; SOCS-BOX ; ANTIVIRAL ACTIVITY ; ENZYME APOBEC3G ; PSI-BLAST ; DEGRADATION ; PROTEASOME
英文摘要

VIF is one of the six accessory proteins of HIV-1. It has been shown to be necessary for the survival of HIV-1 in the human body and for the retention of viral infectivity. It is strongly expected that a new therapeutic strategy against HIV-1 infection could be realized by blocking the biological pathway to VIF. In this paper, a three-dimensional model of VIF was constructed by comparative modeling based on two templates, VHL and NarL, which were used to construct the C-terminal domain and N-terminal domain of VIF, respectively. A model of the VIF-ElonginB-ElonginC complex was constructed, and molecular dynamics simulations were used to investigate the interactions between VIF and ElonginB-ElonginC. Mutagenesis was used to identify the function of some conserved residues in the putative SOCS-box. The results showed that the mutations of the critical residues led to the disruption of the interactions between VIF and ElonginB-ElonginC, consistent with experimental observations. These novel models of VIF and its complex has therefore provided structural information for investigating the function of VIF at the molecular level.

语种英语
WOS记录号WOS:000244063200007
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被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67721
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Jilin Univ, Sch Life Sci, Changchun 130023, Peoples R China
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Lv, Wei,Liu, Zhenming,Jin, Hongwei,et al. Three-dimensional structure of HIV-1VIF constructed by comparative modeling and the function characterization analyzed by molecular dynamics simulation[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2007,5(4):617-626.
APA Lv, Wei,Liu, Zhenming,Jin, Hongwei,Yu, Xianghui,Zhang, Liangren,&Zhang, Lihe.(2007).Three-dimensional structure of HIV-1VIF constructed by comparative modeling and the function characterization analyzed by molecular dynamics simulation.ORGANIC & BIOMOLECULAR CHEMISTRY,5(4),617-626.
MLA Lv, Wei,et al."Three-dimensional structure of HIV-1VIF constructed by comparative modeling and the function characterization analyzed by molecular dynamics simulation".ORGANIC & BIOMOLECULAR CHEMISTRY 5.4(2007):617-626.
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