学科主题基础医学
Possible novel roles of poly(rC)-binding protein 1 in SH-SY5Y neurocytes: an analysis using a dynamic Bayesian network
Huo, Li-Rong1,2; Liang, Jian-Tao3; Zou, Jun-Hua2; Wang, Lan-Ying1; Li, Qi4; Wang, Xiao-Min1
关键词PCBP1 RNA interference overexpression Bayesian network
刊名NEUROSCIENCE BULLETIN
2012-06-01
DOI10.1007/s12264-012-1242-6
28期:3页:282-290
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]SPERMIDINE/SPERMINE N-1-ACETYLTRANSFERASE ; 3&prime ; -UNTRANSLATED REGION ; SIGNAL-TRANSDUCTION ; MESSENGER-RNA ; EXPRESSION ; CANCER ; IDENTIFICATION ; TRANSCRIPTS ; LOCALIZATION ; MECHANISM
英文摘要

Poly(rC)-binding protein 1 (PCBP1) belongs to the heterogeneous nuclear ribonucleoprotein family and participates in transcriptional and translational regulation. Previous work has identified transcripts targeted by both knockdown and overexpression of PCBP1 in SH-SY5Y neuroblastoma cells using a microarray or ProteomeLab (TM) protein fractionation 2-dimensions (PF-2D) and quadrupole time-of-flight mass spectrometer. The present study aimed to further determine whether these altered transcripts from major pathways (such as Wnt signaling, TGF-beta signaling, cell cycling, and apoptosis) and two other genes, H2AFX and H2BFS (screened by PF-2D), have spatial relationships.

The genes were studied by qRT-PCR, and dynamic Bayesian network analysis was used to rebuild the coordination network of these transcripts.

PCBP1 controlled the expression or activity of the seven transcripts. Moreover, PCBP1 indirectly regulated MAP2K2, FOS, FST, TP53 and WNT7B through H2AFX or regulated these genes through SAT. In contrast, TP53 and WNT7B are regulated by other genes.

The seven transcripts and PCBP1 are closely associated in a spatial interaction network.

语种英语
WOS记录号WOS:000304464000011
项目编号2011CB504100 ; 81072858 ; 2007CB511902
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; 973 project ; Ministry of Science and Technology of the People&prime ; s Republic of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67722
专题北京大学基础医学院_北京大学医学遗传中心
北京大学第一临床医学院_口腔科
作者单位1.Peking Univ, Ctr Med Genet, Beijing 100083, Peoples R China
2.Genminix Informat Ltd Co, Shanghai 201210, Peoples R China
3.Capital Med Univ, Dept Physiol, Key Lab Neurodegenerat Disorders, Minist Educ, Beijing 100069, Peoples R China
4.Capital Med Univ, Xuan Wu Hosp, Beijing 100053, Peoples R China
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GB/T 7714
Huo, Li-Rong,Liang, Jian-Tao,Zou, Jun-Hua,et al. Possible novel roles of poly(rC)-binding protein 1 in SH-SY5Y neurocytes: an analysis using a dynamic Bayesian network[J]. NEUROSCIENCE BULLETIN,2012,28(3):282-290.
APA Huo, Li-Rong,Liang, Jian-Tao,Zou, Jun-Hua,Wang, Lan-Ying,Li, Qi,&Wang, Xiao-Min.(2012).Possible novel roles of poly(rC)-binding protein 1 in SH-SY5Y neurocytes: an analysis using a dynamic Bayesian network.NEUROSCIENCE BULLETIN,28(3),282-290.
MLA Huo, Li-Rong,et al."Possible novel roles of poly(rC)-binding protein 1 in SH-SY5Y neurocytes: an analysis using a dynamic Bayesian network".NEUROSCIENCE BULLETIN 28.3(2012):282-290.
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