IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients
Huang, Xin1,2; van den Berg, Anke1; Gao, Zifen2; Visser, Lydia1; Nolte, Ilja3; Vos, Hans1; Hepkema, Bouke4; Kooistra, Wierd1; Poppema, Sibrand1; Diepstra, Arjan1
刊名PLOS ONE
2010-05-28
DOI10.1371/journal.pone.0010865
5期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Bernoulli Bursary ; Bernoulli Bursary
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]REED-STERNBERG CELLS ; COMPLEX CLASS-I ; CD4(+) T-CELLS ; DISEASE ; EPITOPE ; HLA-A-ASTERISK-02 ; IDENTIFICATION ; PROTEIN
英文摘要

Background: In Caucasian populations, the tumor cells of Epstein Barr virus (EBV)-positive classical Hodgkin Lymphomas (cHL) patients more frequently express HLA class I and HLA class II molecules compared to EBV-negative cHL patients. HLA expression (in relation to EBV) in Asian cHL patients has not been previously investigated.

Methodology/Principal Findings: We randomly selected 145 cHL patients with formalin-fixed, paraffin embedded tissue blocks available from 5 hospitals from the Northern part of China. Hematoxylin & Eosin-stained slides were used to reclassify the histological subtypes according to the WHO classification. EBV status was determined by visualization of EBERs in tumor cells using in situ hybridization. Membranous expression of HLA molecules was detected by immunohistochemistry using antibodies HC-10 (class I heavy chain) and anti-beta 2-microglobulin for HLA class I, and CR3/43 for HLA class II. EBV+ tumor cells were observed in 40% (58/145) of the cHL patients. As expected, the percentage of EBV+ cases was much higher in the mixed cellularity subtype (71%) than in the nodular sclerosis subtype (16%) (p<0.001). Expression of HLA class I was observed in 79% of the EBV+ cHL cases and in 30% of the EBV- cases (p<0.001). For HLA class II, 52% of EBV+ cHL cases were positive, compared to 43% in EBV- cases (p = 0.28).

Conclusions: The results in the Northern China population were similar to those in the Caucasian population for HLA class I, but not for HLA class II.

语种英语
资助者Bernoulli Bursary ; Bernoulli Bursary
WOS记录号WOS:000278222100003
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67726
Collection北京大学基础医学院_病理学系
作者单位1.Univ Groningen, Dept Pathol & Med Biol, Univ Med Ctr Groningen, Groningen, Netherlands
2.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Univ Groningen, Unit Genet Epidemiol & Bioinformat, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
4.Univ Groningen, Dept Lab Med, Univ Med Ctr Groningen, Groningen, Netherlands
Recommended Citation
GB/T 7714
Huang, Xin,van den Berg, Anke,Gao, Zifen,et al. Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients[J]. PLOS ONE,2010,5(5).
APA Huang, Xin.,van den Berg, Anke.,Gao, Zifen.,Visser, Lydia.,Nolte, Ilja.,...&Diepstra, Arjan.(2010).Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients.PLOS ONE,5(5).
MLA Huang, Xin,et al."Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients".PLOS ONE 5.5(2010).
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