北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 病理学系  > 期刊论文
学科主题: 基础医学
题名:
Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients
作者: Huang, Xin1,2; van den Berg, Anke1; Gao, Zifen2; Visser, Lydia1; Nolte, Ilja3; Vos, Hans1; Hepkema, Bouke4; Kooistra, Wierd1; Poppema, Sibrand1; Diepstra, Arjan1
刊名: PLOS ONE
发表日期: 2010-05-28
DOI: 10.1371/journal.pone.0010865
卷: 5, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: REED-STERNBERG CELLS ; COMPLEX CLASS-I ; CD4(+) T-CELLS ; DISEASE ; EPITOPE ; HLA-A-ASTERISK-02 ; IDENTIFICATION ; PROTEIN
英文摘要:

Background: In Caucasian populations, the tumor cells of Epstein Barr virus (EBV)-positive classical Hodgkin Lymphomas (cHL) patients more frequently express HLA class I and HLA class II molecules compared to EBV-negative cHL patients. HLA expression (in relation to EBV) in Asian cHL patients has not been previously investigated.

Methodology/Principal Findings: We randomly selected 145 cHL patients with formalin-fixed, paraffin embedded tissue blocks available from 5 hospitals from the Northern part of China. Hematoxylin & Eosin-stained slides were used to reclassify the histological subtypes according to the WHO classification. EBV status was determined by visualization of EBERs in tumor cells using in situ hybridization. Membranous expression of HLA molecules was detected by immunohistochemistry using antibodies HC-10 (class I heavy chain) and anti-beta 2-microglobulin for HLA class I, and CR3/43 for HLA class II. EBV+ tumor cells were observed in 40% (58/145) of the cHL patients. As expected, the percentage of EBV+ cases was much higher in the mixed cellularity subtype (71%) than in the nodular sclerosis subtype (16%) (p<0.001). Expression of HLA class I was observed in 79% of the EBV+ cHL cases and in 30% of the EBV- cases (p<0.001). For HLA class II, 52% of EBV+ cHL cases were positive, compared to 43% in EBV- cases (p = 0.28).

Conclusions: The results in the Northern China population were similar to those in the Caucasian population for HLA class I, but not for HLA class II.

语种: 英语
项目资助者: Bernoulli Bursary
WOS记录号: WOS:000278222100003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67726
Appears in Collections:基础医学院_病理学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients.pdf(260KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Univ Groningen, Dept Pathol & Med Biol, Univ Med Ctr Groningen, Groningen, Netherlands
2.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Univ Groningen, Unit Genet Epidemiol & Bioinformat, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
4.Univ Groningen, Dept Lab Med, Univ Med Ctr Groningen, Groningen, Netherlands

Recommended Citation:
Huang, Xin,van den Berg, Anke,Gao, Zifen,et al. Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients[J]. PLOS ONE,2010,5(5).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Huang, Xin]'s Articles
[van den Berg, Anke]'s Articles
[Gao, Zifen]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Huang, Xin]‘s Articles
[van den Berg, Anke]‘s Articles
[Gao, Zifen]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace