IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients
Huang, Xin1,2; van den Berg, Anke1; Gao, Zifen2; Visser, Lydia1; Nolte, Ilja3; Vos, Hans1; Hepkema, Bouke4; Kooistra, Wierd1; Poppema, Sibrand1; Diepstra, Arjan1
刊名PLOS ONE
2010-05-28
DOI10.1371/journal.pone.0010865
5期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]REED-STERNBERG CELLS ; COMPLEX CLASS-I ; CD4(+) T-CELLS ; DISEASE ; EPITOPE ; HLA-A-ASTERISK-02 ; IDENTIFICATION ; PROTEIN
英文摘要

Background: In Caucasian populations, the tumor cells of Epstein Barr virus (EBV)-positive classical Hodgkin Lymphomas (cHL) patients more frequently express HLA class I and HLA class II molecules compared to EBV-negative cHL patients. HLA expression (in relation to EBV) in Asian cHL patients has not been previously investigated.

Methodology/Principal Findings: We randomly selected 145 cHL patients with formalin-fixed, paraffin embedded tissue blocks available from 5 hospitals from the Northern part of China. Hematoxylin & Eosin-stained slides were used to reclassify the histological subtypes according to the WHO classification. EBV status was determined by visualization of EBERs in tumor cells using in situ hybridization. Membranous expression of HLA molecules was detected by immunohistochemistry using antibodies HC-10 (class I heavy chain) and anti-beta 2-microglobulin for HLA class I, and CR3/43 for HLA class II. EBV+ tumor cells were observed in 40% (58/145) of the cHL patients. As expected, the percentage of EBV+ cases was much higher in the mixed cellularity subtype (71%) than in the nodular sclerosis subtype (16%) (p<0.001). Expression of HLA class I was observed in 79% of the EBV+ cHL cases and in 30% of the EBV- cases (p<0.001). For HLA class II, 52% of EBV+ cHL cases were positive, compared to 43% in EBV- cases (p = 0.28).

Conclusions: The results in the Northern China population were similar to those in the Caucasian population for HLA class I, but not for HLA class II.

语种英语
WOS记录号WOS:000278222100003
资助机构Bernoulli Bursary
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67726
专题北京大学基础医学院_病理学系
作者单位1.Univ Groningen, Dept Pathol & Med Biol, Univ Med Ctr Groningen, Groningen, Netherlands
2.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
3.Univ Groningen, Unit Genet Epidemiol & Bioinformat, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
4.Univ Groningen, Dept Lab Med, Univ Med Ctr Groningen, Groningen, Netherlands
推荐引用方式
GB/T 7714
Huang, Xin,van den Berg, Anke,Gao, Zifen,et al. Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients[J]. PLOS ONE,2010,5(5).
APA Huang, Xin.,van den Berg, Anke.,Gao, Zifen.,Visser, Lydia.,Nolte, Ilja.,...&Diepstra, Arjan.(2010).Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients.PLOS ONE,5(5).
MLA Huang, Xin,et al."Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients".PLOS ONE 5.5(2010).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Expression of HLA Cl(260KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, Xin]的文章
[van den Berg, Anke]的文章
[Gao, Zifen]的文章
百度学术
百度学术中相似的文章
[Huang, Xin]的文章
[van den Berg, Anke]的文章
[Gao, Zifen]的文章
必应学术
必应学术中相似的文章
[Huang, Xin]的文章
[van den Berg, Anke]的文章
[Gao, Zifen]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Expression of HLA Class I and HLA Class II by Tumor Cells in Chinese Classical Hodgkin Lymphoma Patients.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。