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学科主题: 药学
题名:
Isolation, characterization and immunological activity of a polysaccharide from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito.
作者: Han, Xiao-Qiang1; Wu, Xiang-Mei1; Chai, Xing-Yun1,2; Chen, Dan3; Dai, Hui4; Dong, Hong-Liang4; Ma, Zhi-Zhong1; Gao, Xiao-Ming4; Tu, Peng-Fei1
关键词: Sarcodon aspratus (Berk.) S. Ito. ; Edible mushroom ; Polysaccharide ; Glucan ; Immunological activity
刊名: FOOD RESEARCH INTERNATIONAL
发表日期: 2011
DOI: 10.1016/j.foodres.2010.06.009
卷: 44, 期:1, 页:489-493
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology
研究领域[WOS]: Food Science & Technology
关键词[WOS]: STRUCTURAL ELUCIDATION ; PLEUROTUS-OSTREATUS ; ALDITOL ACETATES ; PURIFICATION ; MYCELIA ; SUGARS ; BODY ; GLC
英文摘要:

A water-soluble polysaccharide (HCP) with a molecular mass of 6.7 x 10(5) Da determined by high performance size-exclusion chromatography (HPSEC), was isolated from the fruit bodies of Sarcodon aspratus (Berk.) S. Ito., an edible mushroom. HCP was elucidated as a liner glucan with a backbone structure of (1 -> 6)-linked-alpha-D-glucopyranosyl residues by interpretation of the composition analysis, methylation analysis, periodate oxidation experiment, FT-IR, and NMR spectroscopy. Immunological activity evaluation using H-3-thymidine incorporation method revealed that HCP could significantly stimulate the proliferation of the cultured mice spleen lymphocyte in a dose-dependent manner. HCP might be a potential immunomodulator which can be used against pathogens and tumors in health-care food or medicine. This is the first report on the detailed structure elucidation of the polysaccharide from S. aspratus. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
项目资助者: earmarked fund for Modern Agro-industry Technology Research System
WOS记录号: WOS:000288306900068
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67730
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Chinese Acad Sci, S China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Hemorheol Ctr, Dept Med Phys,Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Immunol, Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Han, Xiao-Qiang,Wu, Xiang-Mei,Chai, Xing-Yun,et al. Isolation, characterization and immunological activity of a polysaccharide from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito.[J]. FOOD RESEARCH INTERNATIONAL,2011,44(1):489-493.
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