IR@PKUHSC  > 北京大学第二临床医学院  > 眼科
学科主题临床医学
Intraocular Pressure and Associations in Children. The Gobi Desert Children Eye Study
Yang, Da Yong1,2; Guo, Kai3; Wang, Yan3; Guo, Yuan Yuan3; Yang, Xian Rong3; Jing, Xin Xia3; Guo, Hai Ke2; Tao, Yong4,5; Zhu, Dan3; Jonass, Jost B.6
刊名PLOS ONE
2014-10-08
DOI10.1371/journal.pone.0109355
9期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CENTRAL CORNEAL THICKNESS ; SYSTEMIC BLOOD-PRESSURE ; BEAVER DAM EYE ; INTRACRANIAL-PRESSURE ; PEDIATRIC POPULATION ; CHINESE CHILDREN ; TONO-PEN ; TONOMETER ; GLAUCOMA ; DETERMINANTS
英文摘要

Purpose: To assess the intraocular pressure (IOP) and its association in children in a population living in an oasis in the Gobi Desert.

Methods: The cross-sectional school-based study included all schools in the Ejina region. The children underwent an ophthalmic examination, non-contact tonometry and measurement of blood pressure and body height and weight.

Results: Out of eligible 1911 children, 1565 (81.9%) children with a mean age of 11.9 +/- 3.5 years (range: 6-21 years) participated. Mean spherical refractive error was -1.58 +/- 2.00 diopters. In multivariate analysis, higher IOP (right eye) was associated with younger age (P<0.001; standardized coefficient beta: -0.13; regression coefficient B: -0.13; 95% Confidence interval (CI):-0.18, -0.07), higher diastolic blood pressure (P<0.001;beta:0.13;B:0.05;95%CI:0.03,0.07), higher corneal refractive power (P<0.001;beta:0.11;B:0.23;95%CI:0.12,0.34), more myopic refractive error (P=0.035;beta: -0.06;B: -0.10;95%CI: -0.19, -0.001), and Han Chinese ethnicity of the father (P=0.03;beta:0.06;B:0.42;95%CI:0.04,0.89). If age and diastolic blood pressure were dropped, higher IOP was associated with higher estimated cerebrospinal fluid pressure (CSFP) (P<0.001;beta:0.09; B:0.13;95%CI:0.06,0.21) after adjusting for higher corneal refractive power (P<0.001) and Han Chinese ethnicity of the father (P = 0.04). Correspondingly, higher IOP of the left eye was associated with younger age (P<0.001;beta: -0.15;B: -0.16;95%CI: -0.21, -0.10), female gender (P<0.001;beta:0.09;B:0.65;95%CI:0.30,1.01), higher corneal refractive power (P<0.001;beta:0.08;B:0.19;95%CI:0.06,0.32), more myopic refractive error (P = 0.03;beta: -0.06;B: -0.12;95%CI: -0.22, -0.01), and higher estimated CSFP (P<0.001;beta:0.11;B:0.17;95%CI:0.09,0.24).

Conclusions: In school children, higher IOP was associated with steeper corneal curvature and with younger age and higher blood pressure, or alternatively, with higher estimated CSFP. Corneal curvature radius should be included in the correction of IOP measurements. The potential association between IOP and CSFP as also assumed in adults may warrant further research.

语种英语
WOS记录号WOS:000345204000064
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67735
专题北京大学第二临床医学院_眼科
作者单位1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Southern Med Univ, Guangzhou, Guangdong, Peoples R China
3.Guangdong Gen Hosp, Guangdong Acad Med Sci, Dept Ophthalmol, Guangzhou, Guangdong, Peoples R China
4.Inner Mongolia Med Univ, Affiliated Hosp, Hohhot, Inner Mongolia, Peoples R China
5.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
6.Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany
推荐引用方式
GB/T 7714
Yang, Da Yong,Guo, Kai,Wang, Yan,et al. Intraocular Pressure and Associations in Children. The Gobi Desert Children Eye Study[J]. PLOS ONE,2014,9(10).
APA Yang, Da Yong.,Guo, Kai.,Wang, Yan.,Guo, Yuan Yuan.,Yang, Xian Rong.,...&Jonass, Jost B..(2014).Intraocular Pressure and Associations in Children. The Gobi Desert Children Eye Study.PLOS ONE,9(10).
MLA Yang, Da Yong,et al."Intraocular Pressure and Associations in Children. The Gobi Desert Children Eye Study".PLOS ONE 9.10(2014).
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