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学科主题: 临床医学
题名:
Intraocular Pressure and Associations in Children. The Gobi Desert Children Eye Study
作者: Yang, Da Yong1,2; Guo, Kai3; Wang, Yan3; Guo, Yuan Yuan3; Yang, Xian Rong3; Jing, Xin Xia3; Guo, Hai Ke2; Tao, Yong4,5; Zhu, Dan3; Jonass, Jost B.6
刊名: PLOS ONE
发表日期: 2014-10-08
DOI: 10.1371/journal.pone.0109355
卷: 9, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: CENTRAL CORNEAL THICKNESS ; SYSTEMIC BLOOD-PRESSURE ; BEAVER DAM EYE ; INTRACRANIAL-PRESSURE ; PEDIATRIC POPULATION ; CHINESE CHILDREN ; TONO-PEN ; TONOMETER ; GLAUCOMA ; DETERMINANTS
英文摘要:

Purpose: To assess the intraocular pressure (IOP) and its association in children in a population living in an oasis in the Gobi Desert.

Methods: The cross-sectional school-based study included all schools in the Ejina region. The children underwent an ophthalmic examination, non-contact tonometry and measurement of blood pressure and body height and weight.

Results: Out of eligible 1911 children, 1565 (81.9%) children with a mean age of 11.9 +/- 3.5 years (range: 6-21 years) participated. Mean spherical refractive error was -1.58 +/- 2.00 diopters. In multivariate analysis, higher IOP (right eye) was associated with younger age (P<0.001; standardized coefficient beta: -0.13; regression coefficient B: -0.13; 95% Confidence interval (CI):-0.18, -0.07), higher diastolic blood pressure (P<0.001;beta:0.13;B:0.05;95%CI:0.03,0.07), higher corneal refractive power (P<0.001;beta:0.11;B:0.23;95%CI:0.12,0.34), more myopic refractive error (P=0.035;beta: -0.06;B: -0.10;95%CI: -0.19, -0.001), and Han Chinese ethnicity of the father (P=0.03;beta:0.06;B:0.42;95%CI:0.04,0.89). If age and diastolic blood pressure were dropped, higher IOP was associated with higher estimated cerebrospinal fluid pressure (CSFP) (P<0.001;beta:0.09; B:0.13;95%CI:0.06,0.21) after adjusting for higher corneal refractive power (P<0.001) and Han Chinese ethnicity of the father (P = 0.04). Correspondingly, higher IOP of the left eye was associated with younger age (P<0.001;beta: -0.15;B: -0.16;95%CI: -0.21, -0.10), female gender (P<0.001;beta:0.09;B:0.65;95%CI:0.30,1.01), higher corneal refractive power (P<0.001;beta:0.08;B:0.19;95%CI:0.06,0.32), more myopic refractive error (P = 0.03;beta: -0.06;B: -0.12;95%CI: -0.22, -0.01), and higher estimated CSFP (P<0.001;beta:0.11;B:0.17;95%CI:0.09,0.24).

Conclusions: In school children, higher IOP was associated with steeper corneal curvature and with younger age and higher blood pressure, or alternatively, with higher estimated CSFP. Corneal curvature radius should be included in the correction of IOP measurements. The potential association between IOP and CSFP as also assumed in adults may warrant further research.

语种: 英语
所属项目编号: NCET-12-0010
项目资助者: Program for New Century Excellent Talents in University (Beijing, China) ; FOK YING TONG education foundation (Hong Kong, China)
WOS记录号: WOS:000345204000064
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67735
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
2.Southern Med Univ, Guangzhou, Guangdong, Peoples R China
3.Guangdong Gen Hosp, Guangdong Acad Med Sci, Dept Ophthalmol, Guangzhou, Guangdong, Peoples R China
4.Inner Mongolia Med Univ, Affiliated Hosp, Hohhot, Inner Mongolia, Peoples R China
5.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
6.Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany

Recommended Citation:
Yang, Da Yong,Guo, Kai,Wang, Yan,et al. Intraocular Pressure and Associations in Children. The Gobi Desert Children Eye Study[J]. PLOS ONE,2014,9(10).
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