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IR@PKUHSC  > 北京大学口腔医学院  > 第二门诊部  > 期刊论文
学科主题: 口腔医学
题名:
Ultrasound-assisted fabrication of a biocompatible magnetic hydroxyapatite
作者: Zhou, Gang1,2; Song, Wei1,2; Hou, Yongzhao1; Li, Qing1,3; Deng, Xuliang4; Fan, Yubo1,2
关键词: hydroxyapatite ; Fe3O4 ; composite ; magnetic ; biocompatibility
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
发表日期: 2014-10-01
DOI: 10.1002/jbm.a.35043
卷: 102, 期:10, 页:3704-3712
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: IRON-OXIDE NANOPARTICLES ; DRUG-DELIVERY ; FE3O4 NANOPARTICLES ; SILICA SHELL ; MG-FERRITE ; TI4+ IONS ; CELLS ; SPHERES ; CANCER ; NANOCOMPOSITE
英文摘要:

This work describes the fabrication and characterization of a biocompatible magnetic hydroxyapatite (HA) using an ultrasound-assisted co-precipitation method. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM) were used to characterize the structure and chemical composition of the produced samples. The M-H loops of synthesized materials were traced using a vibrating sample magnetometer (VSM) and the biocompatibility was evaluated by cell culture and MTT (3-(4,5-dimethylthiazol- 2-yl) 22,5-diphenyltetrazolium bromide) assay. Furthermore, in vivo histopathological examinations were used to evaluate the potential toxicological effects of Fe3O4-HA composites on kidney of SD rats injected intraperitoneally with Fe3O4-HA particles. The results showed that magnetic iron oxide particles first replace OH ions of HA, which are parallel to the c axis, and then enter the HA crystal lattice which produces changes in the crystal surface of HA. Chemical bond interaction was observed between PO43- groups of HA and iron ions of Fe3O4. The saturation magnetization (MS) of Fe3O4-HA composites was 46.36 emu/g obtained from VSM data. Cell culture and MTT assays indicated that HA could affect the growth and proliferation of HEK-293 cells. This Fe3O4-HA composite produced no negative effects on cell morphology, viability, and proliferation and exhibited remarkable biocompatibility. Moreover, no inflammatory cell infiltration was observed in kidney histopathology slices. Therefore, this study succeeds to develop a Fe3O4-HA composite as a prospective biomagnetic material for future applications. (c) 2013 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 2011CB710901 ; 11002016 ; 61227902 ; 10925208 ; 11120101001 ; 2012BAI18B06 ; 2012BAI18B05 ; B13003
项目资助者: National Basic Research Program of China ; NSFC ; National Basic Research Program of China ; National Key Technology RD Program ; 111 Project of China ; International Joint Research Center of Aerospace Biotechnology and Medical Engineering ; Ministry of Science and Technology of China ; Fundamental Research Funds for the Central Universities of China
WOS记录号: WOS:000341130400038
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67737
Appears in Collections:北京大学口腔医学院_第二门诊部_期刊论文

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作者单位: 1.Beihang Univ, Key Lab Biomech & Mech, Minist Educ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
2.Beihang Univ, Res Inst, Shenzhen 518057, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dent Ctr 2, Beijing 100101, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China

Recommended Citation:
Zhou, Gang,Song, Wei,Hou, Yongzhao,et al. Ultrasound-assisted fabrication of a biocompatible magnetic hydroxyapatite[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2014,102(10):3704-3712.
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