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学科主题口腔医学
Ultrasound-assisted fabrication of a biocompatible magnetic hydroxyapatite
Zhou, Gang1,2; Song, Wei1,2; Hou, Yongzhao1; Li, Qing1,3; Deng, Xuliang4; Fan, Yubo1,2
关键词hydroxyapatite Fe3O4 composite magnetic biocompatibility
刊名JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
2014-10-01
DOI10.1002/jbm.a.35043
102期:10页:3704-3712
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]IRON-OXIDE NANOPARTICLES ; DRUG-DELIVERY ; FE3O4 NANOPARTICLES ; SILICA SHELL ; MG-FERRITE ; TI4+ IONS ; CELLS ; SPHERES ; CANCER ; NANOCOMPOSITE
英文摘要

This work describes the fabrication and characterization of a biocompatible magnetic hydroxyapatite (HA) using an ultrasound-assisted co-precipitation method. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and transmission electron microscopy (TEM) were used to characterize the structure and chemical composition of the produced samples. The M-H loops of synthesized materials were traced using a vibrating sample magnetometer (VSM) and the biocompatibility was evaluated by cell culture and MTT (3-(4,5-dimethylthiazol- 2-yl) 22,5-diphenyltetrazolium bromide) assay. Furthermore, in vivo histopathological examinations were used to evaluate the potential toxicological effects of Fe3O4-HA composites on kidney of SD rats injected intraperitoneally with Fe3O4-HA particles. The results showed that magnetic iron oxide particles first replace OH ions of HA, which are parallel to the c axis, and then enter the HA crystal lattice which produces changes in the crystal surface of HA. Chemical bond interaction was observed between PO43- groups of HA and iron ions of Fe3O4. The saturation magnetization (MS) of Fe3O4-HA composites was 46.36 emu/g obtained from VSM data. Cell culture and MTT assays indicated that HA could affect the growth and proliferation of HEK-293 cells. This Fe3O4-HA composite produced no negative effects on cell morphology, viability, and proliferation and exhibited remarkable biocompatibility. Moreover, no inflammatory cell infiltration was observed in kidney histopathology slices. Therefore, this study succeeds to develop a Fe3O4-HA composite as a prospective biomagnetic material for future applications. (c) 2013 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000341130400038
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67737
专题北京大学口腔医学院_第二门诊部
北京大学口腔医学院_特诊科
作者单位1.Beihang Univ, Key Lab Biomech & Mech, Minist Educ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
2.Beihang Univ, Res Inst, Shenzhen 518057, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dent Ctr 2, Beijing 100101, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Gang,Song, Wei,Hou, Yongzhao,et al. Ultrasound-assisted fabrication of a biocompatible magnetic hydroxyapatite[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2014,102(10):3704-3712.
APA Zhou, Gang,Song, Wei,Hou, Yongzhao,Li, Qing,Deng, Xuliang,&Fan, Yubo.(2014).Ultrasound-assisted fabrication of a biocompatible magnetic hydroxyapatite.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,102(10),3704-3712.
MLA Zhou, Gang,et al."Ultrasound-assisted fabrication of a biocompatible magnetic hydroxyapatite".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 102.10(2014):3704-3712.
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