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学科主题: 药物依赖
题名:
NMDA receptor glycine modulatory site in the ventral tegmental area regulates the acquisition, retrieval, and reconsolidation of cocaine reward memory
作者: Zhou, Shuang-jiang1,2,4; Xue, Li-fen3; Wang, Xue-yi1,2; Jiang, Wen-gao3; Xue, Yan-xue3; Liu, Jian-feng3; He, Yin-yin3; Luo, Yi-xiao3; Lu, Lin3
关键词: Conditioned place preference ; Cocaine ; Rewarding memory ; Acquisition ; Reconsolidation ; Ventral tegmental area ; Substantia nigra
刊名: PSYCHOPHARMACOLOGY
发表日期: 2012-05-01
DOI: 10.1007/s00213-011-2551-6
卷: 221, 期:1, 页:79-89
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; LONG-TERM-MEMORY ; MK-801 DISRUPTS RECONSOLIDATION ; SEEKING BEHAVIOR ; DRUG-ADDICTION ; MOLECULAR-MECHANISMS ; GLUTAMATE ; RATS ; ANTAGONIST ; DOPAMINE
英文摘要:

Accumulating clinical and preclinical studies have shown that the memories of the rewarding effects of drugs and their paired cues may contribute to relapse and persistent cocaine use. Glutaminergic actions in the ventral tegmental area (VTA) have been shown to regulate the rewarding effect of drugs and conditioned responses to drug-associated cues, but the role of the VTA in the acquisition, retrieval, and reconsolidation of cocaine cues is not yet known.

In the present study, we used 7-chlorothiokynurenic acid (7-CTKA), an N-methyl-D-aspartate (NMDA) receptor glycine modulatory site antagonist with no rewarding effects, to examine the role of the NMDA receptor glycine modulatory site in the acquisition, retrieval, and reconsolidation of cocaine-related reward memory using the conditioned place preference (CPP) paradigm.

Separate groups of Sprague-Dawley rats were trained to acquire cocaine-induced CPP. Vehicle or 7-CTKA was microinjected into the VTA or substantia nigra (SN) (5 mu g/mu l) at different time points: 10 min before each CPP training session (acquisition), 10 min before the reactivation of CPP (retrieval), and immediately after the reactivation of CPP (reconsolidation). Cocaine-induced CPP was retested 24 h and 1 and 2 weeks after 7-CTKA administration. 7-CTKA microinjected into the VTA, but not SN, significantly impaired the acquisition, retrieval, and reconsolidation of cocaine-induced CPP without affecting cocaine-induced locomotion.

Our findings suggest that the NMDA receptor glycine modulatory site in the VTA plays a major role in cocaine reward memory, and NMDA receptor glycine site antagonists may be potential pharmacotherapies for the management of relapse.

语种: 英语
所属项目编号: 30725016 ; 7092058
项目资助者: Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
WOS记录号: WOS:000302695000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67741
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Hebei Med Univ, Inst Mental Hlth, Shijiazhuang 050031, Peoples R China
2.Hebei Med Univ, Hebei Brain Ageing & Cognit Neurosci Lab, Shijiazhuang 050031, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
4.Peking Univ, Beijing Huilongguan Hosp, Beijing 100096, Peoples R China

Recommended Citation:
Zhou, Shuang-jiang,Xue, Li-fen,Wang, Xue-yi,et al. NMDA receptor glycine modulatory site in the ventral tegmental area regulates the acquisition, retrieval, and reconsolidation of cocaine reward memory[J]. PSYCHOPHARMACOLOGY,2012,221(1):79-89.
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