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NMDA receptor glycine modulatory site in the ventral tegmental area regulates the acquisition, retrieval, and reconsolidation of cocaine reward memory
Zhou, Shuang-jiang1,2,4; Xue, Li-fen3; Wang, Xue-yi1,2; Jiang, Wen-gao3; Xue, Yan-xue3; Liu, Jian-feng3; He, Yin-yin3; Luo, Yi-xiao3; Lu, Lin3
关键词Conditioned place preference Cocaine Rewarding memory Acquisition Reconsolidation Ventral tegmental area Substantia nigra
刊名PSYCHOPHARMACOLOGY
2012-05-01
DOI10.1007/s00213-011-2551-6
221期:1页:79-89
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]CONDITIONED PLACE PREFERENCE ; LONG-TERM-MEMORY ; MK-801 DISRUPTS RECONSOLIDATION ; SEEKING BEHAVIOR ; DRUG-ADDICTION ; MOLECULAR-MECHANISMS ; GLUTAMATE ; RATS ; ANTAGONIST ; DOPAMINE
英文摘要

Accumulating clinical and preclinical studies have shown that the memories of the rewarding effects of drugs and their paired cues may contribute to relapse and persistent cocaine use. Glutaminergic actions in the ventral tegmental area (VTA) have been shown to regulate the rewarding effect of drugs and conditioned responses to drug-associated cues, but the role of the VTA in the acquisition, retrieval, and reconsolidation of cocaine cues is not yet known.

In the present study, we used 7-chlorothiokynurenic acid (7-CTKA), an N-methyl-D-aspartate (NMDA) receptor glycine modulatory site antagonist with no rewarding effects, to examine the role of the NMDA receptor glycine modulatory site in the acquisition, retrieval, and reconsolidation of cocaine-related reward memory using the conditioned place preference (CPP) paradigm.

Separate groups of Sprague-Dawley rats were trained to acquire cocaine-induced CPP. Vehicle or 7-CTKA was microinjected into the VTA or substantia nigra (SN) (5 mu g/mu l) at different time points: 10 min before each CPP training session (acquisition), 10 min before the reactivation of CPP (retrieval), and immediately after the reactivation of CPP (reconsolidation). Cocaine-induced CPP was retested 24 h and 1 and 2 weeks after 7-CTKA administration. 7-CTKA microinjected into the VTA, but not SN, significantly impaired the acquisition, retrieval, and reconsolidation of cocaine-induced CPP without affecting cocaine-induced locomotion.

Our findings suggest that the NMDA receptor glycine modulatory site in the VTA plays a major role in cocaine reward memory, and NMDA receptor glycine site antagonists may be potential pharmacotherapies for the management of relapse.

语种英语
WOS记录号WOS:000302695000007
项目编号30725016 ; 7092058
资助机构Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67741
专题中国药物依赖性研究所
作者单位1.Hebei Med Univ, Inst Mental Hlth, Shijiazhuang 050031, Peoples R China
2.Hebei Med Univ, Hebei Brain Ageing & Cognit Neurosci Lab, Shijiazhuang 050031, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
4.Peking Univ, Beijing Huilongguan Hosp, Beijing 100096, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Shuang-jiang,Xue, Li-fen,Wang, Xue-yi,et al. NMDA receptor glycine modulatory site in the ventral tegmental area regulates the acquisition, retrieval, and reconsolidation of cocaine reward memory[J]. PSYCHOPHARMACOLOGY,2012,221(1):79-89.
APA Zhou, Shuang-jiang.,Xue, Li-fen.,Wang, Xue-yi.,Jiang, Wen-gao.,Xue, Yan-xue.,...&Lu, Lin.(2012).NMDA receptor glycine modulatory site in the ventral tegmental area regulates the acquisition, retrieval, and reconsolidation of cocaine reward memory.PSYCHOPHARMACOLOGY,221(1),79-89.
MLA Zhou, Shuang-jiang,et al."NMDA receptor glycine modulatory site in the ventral tegmental area regulates the acquisition, retrieval, and reconsolidation of cocaine reward memory".PSYCHOPHARMACOLOGY 221.1(2012):79-89.
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