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学科主题: 临床医学
题名:
The diagnostic value of Ki-67, P53 and P63 in distinguishing partial Hydatidiform mole from hydropic abortion
作者: Chen, Yunxin1; Shen, Danhua1; Gu, Yiqun2; Zhong, Pingping2; Xie, Junlin2; Song, Qiujin1
关键词: Hydropic abortion ; partial mole ; P53 ; Ki-67 ; P63 ; immunohistochemistry ; differential diagnosis
刊名: WIENER KLINISCHE WOCHENSCHRIFT
发表日期: 2012-03-01
DOI: 10.1007/s00508-011-0119-4
卷: 124, 期:5-6, 页:184-187
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: GESTATIONAL TROPHOBLASTIC DISEASES ; CELL NUCLEAR ANTIGEN ; EXPRESSIONS
英文摘要:

BACKGROUND AND AIMS: The aim of the present study was to investigate the expression of Ki-67, P53 and P63 in hydropic abortion and partial mole and to explore possible role of these three parameters in distinguishing partial mole from hydropic. METHODS: The hydropic abortion (n = 13) and partial mole (n = 23) were retrieved from the files of 2002 to 2010 at the Department of Pathology, Peking University People′s Hospital and Department of Pathology, Haidian Maternal and Child Health Hospita1. All cases had typical histological features and complete clinical information. All pathologic diagnoses were reviewed by two gynaecologic pathologists and had no conflict. All cases showed P57 negative, which can exclude the diagnosis of CHM. An immunochemical study of the expressions of Ki-67, P53 and P63 was performed. RESULTS: Microscopically, the pathologic characteristics of a HA include villous oedema with minimal to no cistern formation and mild trophoblastic hyperplasia. In contrast, the pathologic features of PHM were characterized by focal trophoblastic hyperplasia and a variable degree of hydropic swelling with central cistern formation. The Ki-67 expression was observed in the nuclear of cytotrophoblastic cell and intermediate trophoblasts population within placental tissue. The Ki-67 expression in HA is less than that in PHM. The p53 expression was observed in the nuclear of cytotrophoblastic cell and intermediate trophoblasts population within placental tissue. There was a significant difference between HA and PHM. Positive staining for P63 was localized in the nuclei of cytotrophoblastic cell population. No significant difference was observed in positive rate of p63 expression between HA and PHM. CONCLUSION: The high Ki-67 labeling index and over-expression of p53, detected by immunohistochemistry, could serve as useful adjuncts to conventional methods of diagnosis in distinguishing PHM from HA. Due to, however, the limited samples, it needs to expand the number of the cases to verify this conclusion.

语种: 英语
所属项目编号: RDC2011-01
项目资助者: People&prime ; s Hospital of Peking University
WOS记录号: WOS:000302374700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67759
Appears in Collections:北京大学第二临床医学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100044, Peoples R China
2.Haidian Maternal & Child Hlth Hosp, Dept Pathol, Beijing, Peoples R China

Recommended Citation:
Chen, Yunxin,Shen, Danhua,Gu, Yiqun,et al. The diagnostic value of Ki-67, P53 and P63 in distinguishing partial Hydatidiform mole from hydropic abortion[J]. WIENER KLINISCHE WOCHENSCHRIFT,2012,124(5-6):184-187.
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