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学科主题基础医学
Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity
Yang, Shaomin1,2; Guo, Xinhua1; Debnath, Gargi1; Mohandas, Narla1; An, Xiuli1,3
关键词4.1R beta-catenin E-cadherin Adherens junction Actin cytoskeleton Epithelial cell
刊名BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
2009-07-01
DOI10.1016/j.bbamem.2009.03.022
1788期:7页:1458-1465
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CELL-CELL ADHESION ; HUMAN-ERYTHROCYTE-MEMBRANE ; ALPHA-CATENIN ; FUNCTIONAL-CHARACTERIZATION ; ACTIN-BINDING ; GLYCOPHORIN-C ; GENE FAMILY ; IN-VITRO ; MOLECULAR-CLONING ; SKELETON
英文摘要

Protein 4.1R (4.1R) is the prototypical member of the protein 4.1 superfamily comprising of the protein 4.1 family (4.1R, 4.1B, 4.1G and 4.1N) and ERM family (ezrin. radixin and meosin). These proteins in general serve as adaptors between the membrane and the cytoskeleton. Here we show that 4.1 R expressed in the gastric epithelial cells associates with adherens junction protein beta-catenin. Biochemical examination of 4.1R-deficient stomach epithelia revealed a selective reduction of beta-catenin which is accompanied by a weaker linkage of E-cadherin to the cytoskeleton. In addition, organization of actin cytoskeleton was altered in 4.1R-deficient cells. Moreover, histological examination revealed that cell-cell contacts are impaired and gastric glands are disorganized in 4.1R null stomach epithelia. These results demonstrate an important and previously unidentified role of 4.1R in linking the cadherin/catenin complex to the cytoskeleton through its direct interaction with beta-catenin and in regulating the integrity of adherens junction. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000267006200005
项目编号DK26263 ; DK32094 ; HL31579
资助机构NIH
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被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67766
专题北京大学基础医学院_病理学系
北京大学基础医学院
作者单位1.New York Blood Ctr, Red Cell Physiol Lab, New York, NY 10065 USA
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100191, Peoples R China
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GB/T 7714
Yang, Shaomin,Guo, Xinhua,Debnath, Gargi,et al. Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2009,1788(7):1458-1465.
APA Yang, Shaomin,Guo, Xinhua,Debnath, Gargi,Mohandas, Narla,&An, Xiuli.(2009).Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,1788(7),1458-1465.
MLA Yang, Shaomin,et al."Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity".BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1788.7(2009):1458-1465.
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