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学科主题: 基础医学
题名:
Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity
作者: Yang, Shaomin1,2; Guo, Xinhua1; Debnath, Gargi1; Mohandas, Narla1; An, Xiuli1,3
关键词: 4.1R ; beta-catenin ; E-cadherin ; Adherens junction ; Actin cytoskeleton ; Epithelial cell
刊名: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
发表日期: 2009-07-01
DOI: 10.1016/j.bbamem.2009.03.022
卷: 1788, 期:7, 页:1458-1465
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CELL-CELL ADHESION ; HUMAN-ERYTHROCYTE-MEMBRANE ; ALPHA-CATENIN ; FUNCTIONAL-CHARACTERIZATION ; ACTIN-BINDING ; GLYCOPHORIN-C ; GENE FAMILY ; IN-VITRO ; MOLECULAR-CLONING ; SKELETON
英文摘要:

Protein 4.1R (4.1R) is the prototypical member of the protein 4.1 superfamily comprising of the protein 4.1 family (4.1R, 4.1B, 4.1G and 4.1N) and ERM family (ezrin. radixin and meosin). These proteins in general serve as adaptors between the membrane and the cytoskeleton. Here we show that 4.1 R expressed in the gastric epithelial cells associates with adherens junction protein beta-catenin. Biochemical examination of 4.1R-deficient stomach epithelia revealed a selective reduction of beta-catenin which is accompanied by a weaker linkage of E-cadherin to the cytoskeleton. In addition, organization of actin cytoskeleton was altered in 4.1R-deficient cells. Moreover, histological examination revealed that cell-cell contacts are impaired and gastric glands are disorganized in 4.1R null stomach epithelia. These results demonstrate an important and previously unidentified role of 4.1R in linking the cadherin/catenin complex to the cytoskeleton through its direct interaction with beta-catenin and in regulating the integrity of adherens junction. (C) 2009 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: DK26263 ; DK32094 ; HL31579
项目资助者: NIH
WOS记录号: WOS:000267006200005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67766
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.New York Blood Ctr, Red Cell Physiol Lab, New York, NY 10065 USA
2.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Shaomin,Guo, Xinhua,Debnath, Gargi,et al. Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2009,1788(7):1458-1465.
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