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学科主题: 临床医学
题名:
Absence of glomerular IgG4 deposition in patients with membranous nephropathy may indicate malignancy
作者: Qu, Zhen1; Liu, Gang1; Li, Jun1; Wu, Li-hua2; Tan, Ying1; Zheng, Xin1; Ao, Jie1; Zhao, Ming-hui1
关键词: IgG subclasses ; malignancy ; membranous nephropathy
刊名: NEPHROLOGY DIALYSIS TRANSPLANTATION
发表日期: 2012-05-01
DOI: 10.1093/ndt/gfr534
卷: 27, 期:5, 页:1931-1937
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation ; Urology & Nephrology
研究领域[WOS]: Transplantation ; Urology & Nephrology
关键词[WOS]: C-REACTIVE PROTEIN ; T-HELPER-CELLS ; CARCINOEMBRYONIC ANTIGEN ; NEPHROTIC SYNDROME ; CANCER ; CARCINOMA ; GLOMERULONEPHRITIS ; ANTIBODY ; RISK ; AGE
英文摘要:

Background. The renal pathological manifestations of malignancy-associated membranous nephropathy (M-MN) and idiopathic membranous nephropathy (I-MN) are similar. It has been suggested that glomerular IgG4 deposition may play an important role in the pathogenesis of I-MN. In the present study, we compared the IgG subclass of immune complex deposition, clinical data and pathological data of patients with M-MN and I-MN.

Methods. Eight patients with M-MN and 42 patients with I-MN diagnosed between 1997 and 2009 in our hospital were enrolled. The clinical and pathological data were retrospectively collected, and glomerular IgG subclass deposition was detected by immunohistochemistry.

Results. Patients with M-MN were older (P = 0.003), with lower serum albumin (P = 0.034) and higher serum C-reactive protein (CRP) level (P = 0.003) than patients with I-MN. The majority of patients with M-MN had earlier pathological stages (P = 0.003) and less IgG deposition in glomeruli (P = 0.029). Absence of IgG4 deposition in glomeruli was notably observed in patients with M-MN (7/8 in M-MN versus 6/42 in I-MN, P < 0.001) and it was an independent predictor for occurrence of malignancy (hazard ratio 0.065, 95% confidence intervals 0.007-0.571, P = 0.014).

Conclusion. Absence of glomerular IgG4 deposition, together with older age, severe hypoalbuminemia and high serum CRP level could be useful clues to differentiate M-MN from I-MN.

语种: 英语
所属项目编号: IRT0803
项目资助者: Program for Chang Jiang Scholars and Innovative Research Team in University (PCSIRT)
WOS记录号: WOS:000303596000037
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67769
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peking Univ Hosp 1, Inst Nephrol,Renal Dis, Minist Hlth China,Renal Div,Dept Med,Key Lab, Beijing 100871, Peoples R China
2.Ningxia Med Coll, Affiliated Hosp, Dept Nephrol, Yinchuan, Peoples R China

Recommended Citation:
Qu, Zhen,Liu, Gang,Li, Jun,et al. Absence of glomerular IgG4 deposition in patients with membranous nephropathy may indicate malignancy[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2012,27(5):1931-1937.
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