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学科主题: 临床医学
题名:
Effects of Interferon-Alpha Treatment on the Incidence of Hyperglycemia in Chronic Hepatitis C Patients: A Systematic Review and Meta-Analysis
作者: Zhang, Wei; Rao, Hui-Ying; Feng, Bo; Liu, Feng; Wei, Lai
刊名: PLOS ONE
发表日期: 2012-06-29
DOI: 10.1371/journal.pone.0039272
卷: 7, 期:6
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SUSTAINED VIROLOGICAL RESPONSE ; GLUCOSE ABNORMALITIES ; CLINICAL-RESEARCH ; CONTROLLED TRIALS ; PUBLICATION BIAS ; RISK-FACTOR ; HETEROGENEITY ; VIRUS ; EPIDEMIOLOGY ; INFECTION
英文摘要:

Background: There is a significant association between effects of interferon-alpha treatment and the risk of developing hyperglycemia in patients with chronic hepatitis C virus (HCV) infection. The objective of this systematic review and meta-analysis on the basis of published observational studies was to estimate risk of hyperglycemia in chronic HCV patients who had acquired sustained virological responses (SVR) compared to those without SVR.

Methodology: We identified eligible studies by searching the relevant databases, including PubMed, Embase, and Google, for papers published between January 1990 and April 2011. The selection of eligible papers was carried out using a scoring system based on guidelines and inclusion criteria that were established before the articles were identified. Heterogeneity across studies was determined and the meta-analysis was performed following standard guidelines.

Conclusions: Eleven eligible studies provided data of the incidence of hyperglycemia in chronic hepatitis C patients with SVR in comparison with patients without these conditions. The results demonstrated that SVR was associated with a lower risk of hyperglycemia (odds ratio = 0.497, 95% confidence interval 0.421-0.587, p<0.001), and there was no evidence of any substantial between-study heterogeneity (I-2 = 24.4%, p>0.1). Results of meta-regression showed patients with different baseline glucose (normal vs. abnormal) and patients with co-infected HIV (presence vs. absence) as the sources of low heterogeneity (p<0.15). The lowest risk of hyperglycemia was described in patients with normal glucose baseline (OR = 0.402, 95% CI 0.297-0.543, p<0.001). This is the first systematic review and meta-analysis performed to examine the association between SVR and risk of hyperglycemia in patients with HCV infection. Our meta-analysis suggests that SVR reduce the risk of developing glucose abnormalities, especially in patients with normal glucose baseline.

语种: 英语
所属项目编号: 2008ZX10002-012 ; 2008ZX10002-013 ; 2012ZX10002003
项目资助者: National Science and Technology Major Project for Infectious Diseases Control
WOS记录号: WOS:000305892100038
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67781
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, Peking Univ Peoples Hosp, Peking Univ Hepatol Inst, Beijing Key Lab Hepatitis & Immunotherapy Liver D, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Wei,Rao, Hui-Ying,Feng, Bo,et al. Effects of Interferon-Alpha Treatment on the Incidence of Hyperglycemia in Chronic Hepatitis C Patients: A Systematic Review and Meta-Analysis[J]. PLOS ONE,2012,7(6).
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