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学科主题: 临床医学
题名:
Differentiation of hematopoietic stem cells into hepatocytes in liver fibrosis in rats
作者: Zhan, Y.; Wang, Y.; Wei, L.; Chen, H.; Cong, X.; Fei, R.; Gao, Y.; Liu, F.
刊名: TRANSPLANTATION PROCEEDINGS
发表日期: 2006-11-01
DOI: 10.1016/j.transproceed.2006.08.132
卷: 38, 期:9, 页:3082-3085
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Surgery ; Transplantation
研究领域[WOS]: Immunology ; Surgery ; Transplantation
关键词[WOS]: BONE-MARROW-CELLS ; HEPATIC STELLATE CELLS ; IN-VIVO ; TISSUE ; REGENERATION ; MICE
英文摘要:

It has been reported that hematopoietic stem cells (HSC) can differentiate into hepatocytes in the normal liver and in some pathologic environments. The aim of this study was to investigate whether HSC can differentiate into hepatocytes in cases of established liver fibrosis. Rat liver fibrosis was induced by subcutaneous injection of tetrachloride (CCl4). Thy(+)CD3(-)CD45RA(-) HSC in bone marrow cells, which had been enriched by fluorescence-activated cell sorting (FACS), were labeled with PKH26-GL, and autologously transplanted into CCl4-treated rats. The expressions of albumin (Alb), cytokeratin 8 (CK8), and alpha-smooth muscle actin (SNIA) were determined by immunofluorescence methods. The PKH26-GL labeled Thy(+)CD3(-)CD45RA(-) HSC expressed the hepatocyte-specific markers Alb and CK8, but did not express alpha-SMA in liver fibrosis. Thy(+)CD3(-)CD45RA(-) HSC differentiated into hepatocytes, but not into hepatic stellate cells. In conclusion, autologous stem cell transplantation may be helpful to treat hepatic

语种: 英语
WOS记录号: WOS:000242294500085
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67787
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Zhan, Y.,Wang, Y.,Wei, L.,et al. Differentiation of hematopoietic stem cells into hepatocytes in liver fibrosis in rats[J]. TRANSPLANTATION PROCEEDINGS,2006,38(9):3082-3085.
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