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Versatile hybrid polyethyleneimine-mesoporous carbon nanoparticles for targeted delivery
Wan, Long1; Zhao, Qinfu1; Zhao, Peng2; He, Bing3; Jiang, Tongying1; Zhang, Qiang3; Wang, Siling1
刊名CARBON
2014-11-01
DOI10.1016/j.carbon.2014.07.050
79页:123-134
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]Chemistry ; Materials Science
关键词[WOS]WATER-SOLUBLE DRUG ; SILICA NANOPARTICLES ; MAGNETIC-RESONANCE ; CONTROLLED-RELEASE ; PACLITAXEL ; CANCER ; CYTOTOXICITY ; THERAPY ; NANOSPHERES ; STABILITY
英文摘要

To meet the needs of targeted drug delivery and medical imaging, uniform mesoporous carbon spheres (UMCS) were functionalized using hyperbranched polyethyleneimine (PEI) covalently linked with fluorescein isothiocyanate (FITC) and folic acid (FA). Folate-receptor-positive KB cancer cells internalized five times more nanoparticles than A549 cells deficient in folate receptors in vitro using flow cytometry and confocal microscopy. The in vivo distribution results also confirmed that the FA-PEI-FITC-UMCS nanoparticles could target the FA-positive tumors. In addition, the specifically targeted hybrid carbon nanoparticles exhibited non-cytotoxic and controlled intracellular release (pH dependent) of the loaded agents. The in vivo antitumor effect of the paclitaxel (PTX)-loaded nanoparticles was investigated in Kunming mice harboring a hepatic H22 tumor. PTX-loaded FA-PEI-UMCS nanoparticles displayed superior antitumor effects compared to other PTX formulations, and the tumor growth inhibition rate was 86.53% compared with the control group (saline) for the enhanced targeted accumulation of NPs in tumor cells. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000342657100013
项目编号2009CB930300 ; 81273449
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Key Laboratory of Drug Preparation Design &amp ; Evaluation of Liaoning Provincial Education Department ; Shenyang Special Fund for Exploration of Intellectual Resources
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67789
专题北京大学药学院
北京大学基础医学院
作者单位1.Shenyang Sunshine Pharmaceut CO LTD, Shenyang 110027, Peoples R China
2.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Shenyang 110016, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wan, Long,Zhao, Qinfu,Zhao, Peng,et al. Versatile hybrid polyethyleneimine-mesoporous carbon nanoparticles for targeted delivery[J]. CARBON,2014,79:123-134.
APA Wan, Long.,Zhao, Qinfu.,Zhao, Peng.,He, Bing.,Jiang, Tongying.,...&Wang, Siling.(2014).Versatile hybrid polyethyleneimine-mesoporous carbon nanoparticles for targeted delivery.CARBON,79,123-134.
MLA Wan, Long,et al."Versatile hybrid polyethyleneimine-mesoporous carbon nanoparticles for targeted delivery".CARBON 79(2014):123-134.
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