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学科主题: 药学
题名:
Versatile hybrid polyethyleneimine-mesoporous carbon nanoparticles for targeted delivery
作者: Wan, Long1; Zhao, Qinfu1; Zhao, Peng2; He, Bing3; Jiang, Tongying1; Zhang, Qiang3; Wang, Siling1
刊名: CARBON
发表日期: 2014-11-01
DOI: 10.1016/j.carbon.2014.07.050
卷: 79, 页:123-134
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Materials Science
关键词[WOS]: WATER-SOLUBLE DRUG ; SILICA NANOPARTICLES ; MAGNETIC-RESONANCE ; CONTROLLED-RELEASE ; PACLITAXEL ; CANCER ; CYTOTOXICITY ; THERAPY ; NANOSPHERES ; STABILITY
英文摘要:

To meet the needs of targeted drug delivery and medical imaging, uniform mesoporous carbon spheres (UMCS) were functionalized using hyperbranched polyethyleneimine (PEI) covalently linked with fluorescein isothiocyanate (FITC) and folic acid (FA). Folate-receptor-positive KB cancer cells internalized five times more nanoparticles than A549 cells deficient in folate receptors in vitro using flow cytometry and confocal microscopy. The in vivo distribution results also confirmed that the FA-PEI-FITC-UMCS nanoparticles could target the FA-positive tumors. In addition, the specifically targeted hybrid carbon nanoparticles exhibited non-cytotoxic and controlled intracellular release (pH dependent) of the loaded agents. The in vivo antitumor effect of the paclitaxel (PTX)-loaded nanoparticles was investigated in Kunming mice harboring a hepatic H22 tumor. PTX-loaded FA-PEI-UMCS nanoparticles displayed superior antitumor effects compared to other PTX formulations, and the tumor growth inhibition rate was 86.53% compared with the control group (saline) for the enhanced targeted accumulation of NPs in tumor cells. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009CB930300 ; 81273449
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Key Laboratory of Drug Preparation Design &amp ; Evaluation of Liaoning Provincial Education Department ; Shenyang Special Fund for Exploration of Intellectual Resources
WOS记录号: WOS:000342657100013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67789
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Shenyang Sunshine Pharmaceut CO LTD, Shenyang 110027, Peoples R China
2.Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Shenyang 110016, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wan, Long,Zhao, Qinfu,Zhao, Peng,et al. Versatile hybrid polyethyleneimine-mesoporous carbon nanoparticles for targeted delivery[J]. CARBON,2014,79:123-134.
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