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学科主题: 临床医学
题名:
Feasibility of diagnosing unstable plaque in patients with acute coronary syndrome using iMap-IVUS
作者: Liu, Jian; Wang, Zhao; Wang, Wei-min; Li, Qi; Ma, Yu-liang; Liu, Chuan-fen; Lu, Ming-yu; Zhao, Hong
关键词: Acute coronary syndrome ; Intravascular ultrasound ; Unstable plaque
刊名: JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
发表日期: 2015-11-01
DOI: 10.1631/jzus.B1500206
卷: 16, 期:11, 页:924-930
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: ATHEROSCLEROTIC PLAQUE ; VIRTUAL HISTOLOGY ; ULTRASOUND ; COMPONENTS
英文摘要:

To compare the plaque composition between stable and unstable plaques, characterize unstable plaque by using iMap-intravascular ultrasound (IVUS), and quantify the diagnostic criteria for unstable plaque.

Thirty-three acute coronary syndrome (ACS) patients who had undergone coronary angiography and IVUS from February 19, 2014 to December 19, 2014 at Peking University People′s Hospital were enrolled in the study. Baseline data were collected. The patients were divided into two groups according to their gray-scale IVUS imaging, stable plaque and unstable plaque. A difference-in-difference evaluation was performed using the baseline data and off-line iMap imaging results between the two groups. A receiver operating characteristic (ROC) curve was constructed to obtain the optimal cut-off value to diagnose unstable plaque.

Percentages of fibrotic and necrotic tissues, absolute values of lipidic, necrotic, and calcified tissues, and plaque burden were independent predictors for unstable plaque. Absolute necrotic area was the best predictor and exhibited the highest diagnostic value for plaque vulnerability (area under the curve (AUC)=0.806, P=0.000, 95% CI (0.718, 0.894)). The cut-off score for predicting unstable plaque was 4.0 mm(2).

This study attempted to propose a cut-off value based on absolute necrotic area using iMap-IVUS to predict plaque vulnerability in patients with ACS. This score might provide a valuable reference for diagnosing unstable plaque.

语种: 英语
所属项目编号: 2014-2-4085
项目资助者: Capital Health Research and Development of Special, China
WOS记录号: WOS:000364941800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67792
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Liu, Jian,Wang, Zhao,Wang, Wei-min,et al. Feasibility of diagnosing unstable plaque in patients with acute coronary syndrome using iMap-IVUS[J]. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B,2015,16(11):924-930.
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