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A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor
Lei, HT; An, P; Song, SM; Liu, XY; He, LW; Wu, J; Meng, L; Liu, MS; Yang, JS; Shou, CC
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
2002-11-08
DOI10.1074/jbc.M203103200
277期:45页:43137-43142
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]TYROSINE KINASE ; ANGIOGENESIS ; IDENTIFICATION ; EXPRESSION ; INTEGRIN ; CANCER ; ALPHA(V)BETA(3) ; REGRESSION ; SUPPRESSES ; SELECTION
英文摘要

Vascular endothelial growth factor (VEGF), one of the most important angiogenic factors, plays an essential role in both physiological and pathological angiogenesis. The VEGF receptor KDR/Flk-1 (a kinase domain receptor) mediates various biological activities of VEGF related to proliferation, differentiation, and migration of endothelial cells. Here we present a novel peptide designated K237-(HTMYYHHYQHHL), which was isolated from a phage-displayed peptide library, binding to KDR with high affinity and specificity. By interfering with the VEGF-KDR interaction, the peptide K237 inhibited proliferation of cultured primary human umbilical vein endothelial cells induced by recombinant human VEGF,,, in a dose-dependent and cell type-specific manner. The peptide also exerted an anti-angiogenesis activity in vivo as revealed using the chick embryo chorioallantoic membrane angiogenesis assay. Moreover, the peptide K237 significantly inhibited the growth of solid tumors implanted beneath the breasts and their metastases to lungs in severe combined immunodeficient mice. Taken together, these findings suggest that the peptide K237 can functionally disrupt the interaction between VEGF and the KDR receptor and cause potent biological effects that include the inhibition of angiogenesis and tumor growth. As a consequence, this peptide (and its future derivatives) may have use as a potential cancer therapy.

语种英语
WOS记录号WOS:000179081200094
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被引频次:55[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67793
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100034, Peoples R China
2.Peking Union Med Coll, Chinese Acad Med Sci, Inst Med Plant, Beijing 100094, Peoples R China
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Lei, HT,An, P,Song, SM,et al. A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2002,277(45):43137-43142.
APA Lei, HT.,An, P.,Song, SM.,Liu, XY.,He, LW.,...&Shou, CC.(2002).A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor.JOURNAL OF BIOLOGICAL CHEMISTRY,277(45),43137-43142.
MLA Lei, HT,et al."A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor".JOURNAL OF BIOLOGICAL CHEMISTRY 277.45(2002):43137-43142.
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