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学科主题: 临床医学
题名:
Applications of post-translational modifications of FoxO family proteins in biological functions
作者: Zhao, Ying1; Wang, Yachen1; Zhu, Wei-Guo1,2
关键词: FoxO ; post-translational modification ; cancer
刊名: JOURNAL OF MOLECULAR CELL BIOLOGY
发表日期: 2011-10-01
DOI: 10.1093/jmcb/mjr013
卷: 3, 期:5, 页:276-282
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: FORKHEAD TRANSCRIPTION FACTOR ; UBIQUITIN-MEDIATED DEGRADATION ; EXTENDS LIFE-SPAN ; OXIDATIVE-STRESS ; DNA-BINDING ; SUBCELLULAR-LOCALIZATION ; PROTEASOMAL DEGRADATION ; PROMOTES TUMORIGENESIS ; DEPENDENT REGULATION ; SIGNALING PATHWAY
英文摘要:

The functions of the FoxO family proteins, in particular their transcriptional activities, are modulated by post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to different cellular stresses, which in turn regulate the subcellular localization of FoxO family proteins, as well as their half-life, DNA binding, transcriptional activity and ability to interact with other cellular proteins. In this review, we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases.

语种: 英语
所属项目编号: 2011CB910100 ; 30900722 ; 31070691
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China
WOS记录号: WOS:000296292900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67795
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Dept Biochem & Mol Biol, Hlth Sci Ctr, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100191, Peoples R China
2.Peking Univ, Sch Oncol, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Zhao, Ying,Wang, Yachen,Zhu, Wei-Guo. Applications of post-translational modifications of FoxO family proteins in biological functions[J]. JOURNAL OF MOLECULAR CELL BIOLOGY,2011,3(5):276-282.
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