IR@PKUHSC  > 北京大学药学院
学科主题药学
Design, Synthesis and In Vitro Biological Evaluation of 3-styrylbenzimidamides as Potential BACE1 Inhibitors
Niu, Yan; Gao, Haifei; Xu, Fengrong; Liang, Lei; Liu, Peng; Wang, Chao; Yang, Guanyu; Sun, Qi; Xu, Ping
关键词Alzheimer&prime s disease BACE1 inhibitors 3-styrylbenzimidamide CADD
刊名LETTERS IN DRUG DESIGN & DISCOVERY
2013-05-01
10期:4页:297-302
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ALZHEIMERS-DISEASE
英文摘要

A series of 3-styrylbenzimidamides were synthesized and biologically evaluated in a cell free FRET assay as potential BACE1 inhibitors. Some of the synthesized analogues were discovered to have moderate BACE1 inhibitory activities with IC50 values ranging from 9.3 to 295.8 mu M. Molecular docking study proposed that the most potent compound (E)-2d bound to BACE1 differently in S3-S2′ subpockets forming no polar interaction with the catalytic Asp dyad compared with the 3-styrylbenzimidamides. The results would contribute to the further optimizations on benzimidamide scaffold to achieve novel small molecular BACE1 inhibitors with improved potencies.

语种英语
WOS记录号WOS:000317927800002
项目编号21002002 ; 21172012 ; 2012CB518000
资助机构National Natural Science Foundation of China ; National Basic Research Program of China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67798
专题北京大学药学院
北京大学药学院_化学生物学系
北京大学药学院_药物化学系
作者单位Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Med Chem,State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Niu, Yan,Gao, Haifei,Xu, Fengrong,et al. Design, Synthesis and In Vitro Biological Evaluation of 3-styrylbenzimidamides as Potential BACE1 Inhibitors[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2013,10(4):297-302.
APA Niu, Yan.,Gao, Haifei.,Xu, Fengrong.,Liang, Lei.,Liu, Peng.,...&Xu, Ping.(2013).Design, Synthesis and In Vitro Biological Evaluation of 3-styrylbenzimidamides as Potential BACE1 Inhibitors.LETTERS IN DRUG DESIGN & DISCOVERY,10(4),297-302.
MLA Niu, Yan,et al."Design, Synthesis and In Vitro Biological Evaluation of 3-styrylbenzimidamides as Potential BACE1 Inhibitors".LETTERS IN DRUG DESIGN & DISCOVERY 10.4(2013):297-302.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Niu, Yan]的文章
[Gao, Haifei]的文章
[Xu, Fengrong]的文章
百度学术
百度学术中相似的文章
[Niu, Yan]的文章
[Gao, Haifei]的文章
[Xu, Fengrong]的文章
必应学术
必应学术中相似的文章
[Niu, Yan]的文章
[Gao, Haifei]的文章
[Xu, Fengrong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。