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学科主题临床医学
Hematoma growth and outcomes in intracerebral hemorrhage The INTERACT1 study
Delcourt, Candice1; Huang, Yining2; Arima, Hisatomi1; Chalmers, John1; Davis, Stephen M.3; Heeley, Emma L.1; Wang, Jiguang4; Parsons, Mark W.5; Liu, Guorong; Anderson, Craig S.1; INTERACT1 Investigators
刊名NEUROLOGY
2012-07-01
DOI10.1212/WNL.0b013e318260cbba
79期:4页:314-319
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]ACTIVATED FACTOR-VII ; BLOOD-PRESSURE REDUCTION ; ENLARGEMENT ; MORTALITY ; TRIAL
英文摘要

Objective: Uncertainty exists over the size of potential beneficial effects of medical treatments targeting hematoma growth in intracerebral hemorrhage (ICH). We report associations of hematoma growth parameters on clinical outcomes in the pilot phase, Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT1) (ClinicalTrials.gov NCT00226096).

Methods: In randomized patients with both baseline and 24-hour brain CT (n = 335), associations between measures of absolute and relative hematoma growth and 90-day poor outcomes of death and dependency (modified Rankin Scale score 3-5) were assessed in logistic regression models, with data reported as odds ratios (OR) and 95% confidence intervals (CI).

Results: A total of 10.7 mL (1 SD) increase in hematoma volume over 24 hours was strongly associated with poor outcome (adjusted OR 1.72, 95% CI 1.19-2.49; p = 0.004). An association was also evident for relative growth (adjusted OR 1.67,95% 1.22-2.27; p = 0.001 for 1 SD increase). The analyses were adjusted for age, sex, achieved systolic blood pressure, elevated NIH Stroke Scale score (>= 14), hematoma location, baseline hematoma volume, intraventricular extension, antithrombotic therapy, baseline glucose, time from ICH to baseline CT scan, and time from baseline to repeat CT scan. A 1 mL increase in hematoma growth was associated with a 5% (95% CI 2%-9%) higher risk of death or dependency.

Conclusion: Medical treatments, such as rapid intensive blood pressure lowering, could achieve similar to 2-4 mL absolute attenuation of hematoma growth. There is hope that this could translate into modest but still clinically worthwhile (similar to 10%-20% better chance) outcome from ICH. Neurology (R) 2012; 79:314-319

语种英语
WOS记录号WOS:000306690100010
项目编号358395
资助机构National Health and Medical Research Council of Australia ; Australian Research Council ; Servier ; National Health and Medical Research Council of Australia
引用统计
被引频次:75[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67804
专题北京大学第一临床医学院_神经内科
作者单位1.Univ Sydney, Royal Prince Alfred Hosp, George Inst Global Hlth, Sydney, NSW 2006, Australia
2.Peking Univ, Hosp 1, Dept Neurol, Beijing, Peoples R China
3.Univ Melbourne, Royal Melbourne Hosp, Dept Neurol, Melbourne, Vic 3010, Australia
4.Shanghai Res Inst Hypertens, Shanghai, Peoples R China
5.John Hunter Hosp, Hunter Med Res Inst, Dept Neurol, Newcastle, NSW, Australia
6.Baotou Cent Hosp, Dept Neurol, Baotou, Peoples R China
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GB/T 7714
Delcourt, Candice,Huang, Yining,Arima, Hisatomi,et al. Hematoma growth and outcomes in intracerebral hemorrhage The INTERACT1 study[J]. NEUROLOGY,2012,79(4):314-319.
APA Delcourt, Candice.,Huang, Yining.,Arima, Hisatomi.,Chalmers, John.,Davis, Stephen M..,...&INTERACT1 Investigators.(2012).Hematoma growth and outcomes in intracerebral hemorrhage The INTERACT1 study.NEUROLOGY,79(4),314-319.
MLA Delcourt, Candice,et al."Hematoma growth and outcomes in intracerebral hemorrhage The INTERACT1 study".NEUROLOGY 79.4(2012):314-319.
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