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Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study
Jiang, Sisi1,2,3; Yan, Hao1,2,3; Chen, Qiang4; Tian, Lin1,2,3; Lu, Tianlan1,2,3; Tan, Hao-Yang4,5; Yan, Jun1,2,3; Zhang, Dai1,2,3,6,7,8
刊名PLOS ONE
2015-08-13
DOI10.1371/journal.pone.0135468
10期:8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]DORSOLATERAL PREFRONTAL CORTEX ; COGNITIVE DEFICITS ; 1ST-EPISODE SCHIZOPHRENIA ; INTERMEDIATE PHENOTYPES ; NONPSYCHOTIC RELATIVES ; BRAIN ACTIVATION ; GENE-EXPRESSION ; METAANALYSIS ; DYSFUNCTION ; RISK
英文摘要

Background

It has been suggested that working memory deficits is a core feature of symptomatology of schizophrenia, which can be detected in patients and their unaffected relatives. The impairment of working memory has been found related to the abnormal activity of human brain regions in many functional magnetic resonance imaging (fMRI) studies. This study investigated how brain region activation was altered in schizophrenia and how it was inherited independently from performance deficits.

Method

The authors used fMRI method during N-back task to assess working memory related cortical activation in four groups (N = 20 in each group, matching task performance, age, gender and education): schizophrenic patients, their unaffected biological parents, young healthy controls for the patients and older healthy controls for their parents.

Results

Compared to healthy controls, patients showed an exaggerated response in the right dorsolateral prefrontal cortex (brodmann area [BA] 46) and bilateral ventrolateral prefrontal cortex, and had reduced activation in bilateral dorsolateral prefrontal cortex (BA 9). In the conjunction analysis, the effect of genetic risk (parents versus older control) shared significantly overlapped activation with effect of disease (patients versus young control) in the right middle frontal gyrus (BA 46) and left inferior parietal gyrus (BA 40).

Conclusions

Physiological inefficiency of dorsal prefrontal cortex and compensation involvement of ventral prefrontal cortex in working memory function may one physiological characteristics of schizophrenia. And relatively inefficient activation in dorsolateral prefrontal cortex probably can be a promising intermediate phenotype for schizophrenia.

语种英语
WOS记录号WOS:000359492800078
项目编号2011CB707805 ; 81370032 ; 91232305 ; 81361120395 ; 91432304
资助机构National Basic Research Program of China ; National Natural Science Foundation of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67806
专题北京大学精神卫生研究所
北京大学第一临床医学院_妇产科
北京大学精神卫生研究所_精神科
北京大学精神卫生研究所_生化室
作者单位1.Peking Univ, Hosp 6, Beijing 100191, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.Lieber Inst Brain Dev, Baltimore, MD USA
5.Johns Hopkins Univ, Sch Med, Psychiat & Behav Sci, Baltimore, MD USA
6.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
7.Peking Univ Tsinghua Univ Joint Ctr Life Sci, Beijing 100871, Peoples R China
8.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Sisi,Yan, Hao,Chen, Qiang,et al. Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study[J]. PLOS ONE,2015,10(8).
APA Jiang, Sisi.,Yan, Hao.,Chen, Qiang.,Tian, Lin.,Lu, Tianlan.,...&Zhang, Dai.(2015).Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study.PLOS ONE,10(8).
MLA Jiang, Sisi,et al."Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study".PLOS ONE 10.8(2015).
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