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学科主题: 精神卫生
题名:
Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study
作者: Jiang, Sisi1,2,3; Yan, Hao1,2,3; Chen, Qiang4; Tian, Lin1,2,3; Lu, Tianlan1,2,3; Tan, Hao-Yang4,5; Yan, Jun1,2,3; Zhang, Dai1,2,3,6,7,8
刊名: PLOS ONE
发表日期: 2015-08-13
DOI: 10.1371/journal.pone.0135468
卷: 10, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: DORSOLATERAL PREFRONTAL CORTEX ; COGNITIVE DEFICITS ; 1ST-EPISODE SCHIZOPHRENIA ; INTERMEDIATE PHENOTYPES ; NONPSYCHOTIC RELATIVES ; BRAIN ACTIVATION ; GENE-EXPRESSION ; METAANALYSIS ; DYSFUNCTION ; RISK
英文摘要:

Background

It has been suggested that working memory deficits is a core feature of symptomatology of schizophrenia, which can be detected in patients and their unaffected relatives. The impairment of working memory has been found related to the abnormal activity of human brain regions in many functional magnetic resonance imaging (fMRI) studies. This study investigated how brain region activation was altered in schizophrenia and how it was inherited independently from performance deficits.

Method

The authors used fMRI method during N-back task to assess working memory related cortical activation in four groups (N = 20 in each group, matching task performance, age, gender and education): schizophrenic patients, their unaffected biological parents, young healthy controls for the patients and older healthy controls for their parents.

Results

Compared to healthy controls, patients showed an exaggerated response in the right dorsolateral prefrontal cortex (brodmann area [BA] 46) and bilateral ventrolateral prefrontal cortex, and had reduced activation in bilateral dorsolateral prefrontal cortex (BA 9). In the conjunction analysis, the effect of genetic risk (parents versus older control) shared significantly overlapped activation with effect of disease (patients versus young control) in the right middle frontal gyrus (BA 46) and left inferior parietal gyrus (BA 40).

Conclusions

Physiological inefficiency of dorsal prefrontal cortex and compensation involvement of ventral prefrontal cortex in working memory function may one physiological characteristics of schizophrenia. And relatively inefficient activation in dorsolateral prefrontal cortex probably can be a promising intermediate phenotype for schizophrenia.

语种: 英语
所属项目编号: 2011CB707805 ; 81370032 ; 91232305 ; 81361120395 ; 91432304
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000359492800078
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67806
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Hosp 6, Beijing 100191, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.Lieber Inst Brain Dev, Baltimore, MD USA
5.Johns Hopkins Univ, Sch Med, Psychiat & Behav Sci, Baltimore, MD USA
6.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
7.Peking Univ Tsinghua Univ Joint Ctr Life Sci, Beijing 100871, Peoples R China
8.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China

Recommended Citation:
Jiang, Sisi,Yan, Hao,Chen, Qiang,et al. Cerebral Inefficient Activation in Schizophrenia Patients and Their Unaffected Parents during the N-Back Working Memory Task: A Family fMRI Study[J]. PLOS ONE,2015,10(8).
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