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学科主题: 临床医学
题名:
Common variants of the UMOD promoter associated with blood pressure in a community-based Chinese cohort
作者: Han, Jia1,2,3,4; Chen, Yuqing1,2,3,4; Liu, Ying1,2,3,4; Liang, Yu1,2,3,4; Wang, Xingyu5; Liu, Lisheng5; Wang, Fang1,2,3,4; Zhang, Luxia1,2,3,4; Zhang, Hong1,2,3,4; Wang, Haiyan1,2,3,4
关键词: diastolic blood pressure ; single-nucleotide polymorphism ; Tamm-Horsfall protein ; uromodulin
刊名: HYPERTENSION RESEARCH
发表日期: 2012-07-01
DOI: 10.1038/hr.2012.51
卷: 35, 期:7, 页:769-774
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: TAMM-HORSFALL PROTEIN ; ARTERIAL-PRESSURE ; KIDNEY ; HYPERTENSION ; GLYCOPROTEIN ; POPULATION ; DISEASE ; SYSTEM
英文摘要:

Hypertension is an important risk factor for chronic kidney disease. The kidney, in turn, has an important role in the regulation of blood pressure (BP). On the basis of a genome-wide association study, single-nucleotide polymorphisms in the uromodulin (UMOD) promoter region had been considered to influence both renal sodium reabsorption and BP. In this study, we asked whether common variants across the UMOD gene influence BP in a community-based Chinese cohort. We screened seven common variants across the UMOD locus in a community-based population from Beijing, including 1000 individuals with 48% males and an average age of 63.7 +/- 9.0 years. The urinary UMOD concentration was measured by enzyme-linked immunosorbent assay. We then analyzed the association of common variants of UMOD with BP. The UMOD promoter common variant rs13333226 G/A is associated with diastolic BP (DBP), and G allele carriers have higher DBP compared with A/A homozygotes (P = 0.035). The variant rs6497476 C/T predicted the DBP level, with C homozygotes having a higher DBP compared with CT heterozygotes and T homozygotes (P = 0.025). Urinary UMOD excretion was correlated with urinary sodium excretion (R = 0.239, P = 0.656*10(-13)). We determined that common variants of UMOD are associated with DBP level in a community-based Chinese cohort. Hypertension Research (2012) 35, 769-774; doi:10.1038/hr.2012.51; published online 17 May 2012

语种: 英语
所属项目编号: 81070587 ; BMU20110156
项目资助者: National Natural Science Foundation of China ; Chinese 985 Project
WOS记录号: WOS:000306106200017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67809
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
4.Peking Univ, Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
5.Beijing Hypertens League Inst, Beijing, Peoples R China

Recommended Citation:
Han, Jia,Chen, Yuqing,Liu, Ying,et al. Common variants of the UMOD promoter associated with blood pressure in a community-based Chinese cohort[J]. HYPERTENSION RESEARCH,2012,35(7):769-774.
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