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Association of folate deficiency and selected tumor marker concentrations in long-term hexavalent chromium exposed population
Wang, Tian-Cheng1; Song, Yan-Shuang2; Yu, Shan-Fa3; Zhang, Ji4; Wang, Hui5; Gu, Yong-En2; Chen, Tian2; Jia, Guang2
关键词Chromium Folate Occupational exposure Plasma Tumor markers Smoking
刊名INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
2014
DOI10.1016/j.ijheh.2013.03.013
217期:1页:88-94
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health ; Infectious Diseases
研究领域[WOS]Public, Environmental & Occupational Health ; Infectious Diseases
关键词[WOS]CELL LUNG-CANCER ; NEURON-SPECIFIC ENOLASE ; PROGNOSTIC-FACTORS ; FOLIC-ACID ; CARCINOEMBRYONIC ANTIGEN ; COLORECTAL ADENOMAS ; PANCREATIC-CANCER ; CIGARETTE-SMOKING ; DNA METHYLATION ; SCREENING TRIAL
英文摘要

Both hexavalent chromium [Cr(VI)] exposure and folate deficiency have been associated with increased cancer risks. Our previous studies have found folate deficiency in Cr (VI) exposed population. Here the relationship between some tumor markers and folate status in long-term Cr (VI) exposure was investigated carefully to show the multiple aspects of Cr (VI) carcinogenesis. A group of 115 workers occupationally exposed to chromate and 60 matched, unexposed controls in Shandong province of China were recruited. Environmental and biological exposure assessments including personal exposure to airborne Cr and Cr contents in erythrocytes were performed. Serum folate, plasma total homocysteine (tHcy) and plasma carcinoembryonic antigen (CEA), neuron specific enolase (NSE), squamous cell carcinoma antigen (SCC), cytokeratin fragment antigen 21-1 (CYFRA 21-1), cancer antigen 72-4 (CA72-4), as well as or-fetoprotein (AFP) were measured. Smoking index (SI) was also calculated to discriminate possible confounding effects of smoking status. Serum folate level decreased significantly, while plasma tHcy, CEA, NSE, SCC, CYFRA21-1, CA72-4 and AFP concentrations increased significantly after Cr (VI) exposure. Meanwhile, plasma CEA, NSE and SCC were negatively correlated with serum folate. SI was negatively correlated with serum folate but positively correlated with plasma tHcy, CEA and NSE levels. Present study suggests that folate deficiency was associated with increased cancer risks and might be affected by smoking in Cr (VI) exposed population. Folate might play a key role in Cr (VI) carcinogenesis although further detailed investigations are needed to clarify the mechanism of this process. (C) 2013 Elsevier GmbH. All rights reserved.

语种英语
WOS记录号WOS:000328304300012
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67812
专题北京大学公共卫生学院
北京大学医学部管理机构_科学研究处
北京大学公共卫生学院_公共卫生学院
作者单位1.Capital Med Univ, Beijing Tradit Chinese Med Hosp, Dept Clin Lab, Beijing 100010, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
3.Inst Occupat Med Henan Prov, Zhengzhou 450052, Henan Province, Peoples R China
4.Ctr Dis Control & Prevent Jinan City, Jinan 250013, Shandong, Peoples R China
5.Harvard Univ, Sch Med, Dept Global Hlth & Populat, Boston, MA 02115 USA
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GB/T 7714
Wang, Tian-Cheng,Song, Yan-Shuang,Yu, Shan-Fa,et al. Association of folate deficiency and selected tumor marker concentrations in long-term hexavalent chromium exposed population[J]. INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH,2014,217(1):88-94.
APA Wang, Tian-Cheng.,Song, Yan-Shuang.,Yu, Shan-Fa.,Zhang, Ji.,Wang, Hui.,...&Jia, Guang.(2014).Association of folate deficiency and selected tumor marker concentrations in long-term hexavalent chromium exposed population.INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH,217(1),88-94.
MLA Wang, Tian-Cheng,et al."Association of folate deficiency and selected tumor marker concentrations in long-term hexavalent chromium exposed population".INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 217.1(2014):88-94.
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