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学科主题: 公共卫生
题名:
Association of folate deficiency and selected tumor marker concentrations in long-term hexavalent chromium exposed population
作者: Wang, Tian-Cheng1; Song, Yan-Shuang2; Yu, Shan-Fa3; Zhang, Ji4; Wang, Hui5; Gu, Yong-En2; Chen, Tian2; Jia, Guang2
关键词: Chromium ; Folate ; Occupational exposure ; Plasma ; Tumor markers ; Smoking
刊名: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
发表日期: 2014
DOI: 10.1016/j.ijheh.2013.03.013
卷: 217, 期:1, 页:88-94
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health ; Infectious Diseases
研究领域[WOS]: Public, Environmental & Occupational Health ; Infectious Diseases
关键词[WOS]: CELL LUNG-CANCER ; NEURON-SPECIFIC ENOLASE ; PROGNOSTIC-FACTORS ; FOLIC-ACID ; CARCINOEMBRYONIC ANTIGEN ; COLORECTAL ADENOMAS ; PANCREATIC-CANCER ; CIGARETTE-SMOKING ; DNA METHYLATION ; SCREENING TRIAL
英文摘要:

Both hexavalent chromium [Cr(VI)] exposure and folate deficiency have been associated with increased cancer risks. Our previous studies have found folate deficiency in Cr (VI) exposed population. Here the relationship between some tumor markers and folate status in long-term Cr (VI) exposure was investigated carefully to show the multiple aspects of Cr (VI) carcinogenesis. A group of 115 workers occupationally exposed to chromate and 60 matched, unexposed controls in Shandong province of China were recruited. Environmental and biological exposure assessments including personal exposure to airborne Cr and Cr contents in erythrocytes were performed. Serum folate, plasma total homocysteine (tHcy) and plasma carcinoembryonic antigen (CEA), neuron specific enolase (NSE), squamous cell carcinoma antigen (SCC), cytokeratin fragment antigen 21-1 (CYFRA 21-1), cancer antigen 72-4 (CA72-4), as well as or-fetoprotein (AFP) were measured. Smoking index (SI) was also calculated to discriminate possible confounding effects of smoking status. Serum folate level decreased significantly, while plasma tHcy, CEA, NSE, SCC, CYFRA21-1, CA72-4 and AFP concentrations increased significantly after Cr (VI) exposure. Meanwhile, plasma CEA, NSE and SCC were negatively correlated with serum folate. SI was negatively correlated with serum folate but positively correlated with plasma tHcy, CEA and NSE levels. Present study suggests that folate deficiency was associated with increased cancer risks and might be affected by smoking in Cr (VI) exposed population. Folate might play a key role in Cr (VI) carcinogenesis although further detailed investigations are needed to clarify the mechanism of this process. (C) 2013 Elsevier GmbH. All rights reserved.

语种: 英语
所属项目编号: 81072281 ; 81273043
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000328304300012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67812
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Tradit Chinese Med Hosp, Dept Clin Lab, Beijing 100010, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
3.Inst Occupat Med Henan Prov, Zhengzhou 450052, Henan Province, Peoples R China
4.Ctr Dis Control & Prevent Jinan City, Jinan 250013, Shandong, Peoples R China
5.Harvard Univ, Sch Med, Dept Global Hlth & Populat, Boston, MA 02115 USA

Recommended Citation:
Wang, Tian-Cheng,Song, Yan-Shuang,Yu, Shan-Fa,et al. Association of folate deficiency and selected tumor marker concentrations in long-term hexavalent chromium exposed population[J]. INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH,2014,217(1):88-94.
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