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学科主题: 基础医学
题名:
Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population
作者: He, Bing1; Li, Junyan2; Wang, Gang3; Ju, Weina4; Lu, Yadong1; Shi, Yongyong2; He, Lin2; Zhong, Nanbert1,4
关键词: Bipolar disorder ; Case-control study ; Single nuclectide polymorphism ; Type II deiodinase
刊名: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
发表日期: 2009-08-31
DOI: 10.1016/j.pnpbp.2009.05.003
卷: 33, 期:6, 页:986-990
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: CATECHOL-O-METHYLTRANSFERASE ; SUSCEPTIBILITY LOCUS ; THYROID-FUNCTION ; IODOTHYRONINE DEIODINASE ; LINKAGE DISEQUILIBRIUM ; SEROTONIN TRANSPORTER ; CHROMOSOME 4Q35 ; POTENTIAL LOCI ; GENOME SCAN ; RAT-BRAIN
英文摘要:

Objective: Genetic factors play a critical role in the etiology of bipolar disorder (BPAD). Previous studies suggested an association between thyroid dysfunction and BPAD. We hypothesize that genetic variations in the type II deiodinase (DIO2) gene that possibly alter the bioactivity of thyroid hormones are associated with BPAD. Method: A case-control association study was conducted in a subset of Chinese Han population. Two single nucleotide polymorphisms (SNP), open reading frame a (ORFa)-Gly3Asp (rs12885300) and Thr92Ala (rs225014) with potential functions on the activity of DIO2, were selected. The frequencies of allele, genotype and haplotype of the two SNPs were compared between the BPAD patients and the control group. Results: Statistical significance between the BPAD patients and the control group was observed for the allele (chi(2) = 7.746, P = 0.005, df = 1) and genotype frequencies (chi(2) = 8.158, P = 0.017, df = 2) at the locus of ORFa-Gly3Asp, and for the allele (chi(2) = 15.838, P = 7.00e-005, df = 1) and genotype frequencies (chi(2) = 17.236, P = 0.0002, df = 2) at Thr92Ala. Distribution of allele 3Gly and 92Ala were significantly higher in the BPAD patients, with odds ratios of 1.489 [95% confidence interval (CI) = 1,124-1.973] and 1.616 [95% CI = 1.275-2.048], respectively. Individuals with two copies of the variant 3Gly or 92Ala were at greater risk of BPAD than individuals with one copy (dose-response manner). Haplotypes ORFa-3Asp-92Ala and ORFa-3Gly92Ala indicated higher susceptibility for BPAD with odds ratios of 3.759 (95% CI = 2.013-7.020) and 1.292 (95% CI = 1.017-1.642), respectively, while ORFa-3Asp-92Thr probably played a protective role with an odds ratio of 0.395 (95% CI = 0.284-0.549). Conclusion: Data generated from this study supported our hypothesis that genetic variations of the DIO2 gene were associated with BPAD and suggested further consideration on the possible involvement of these functionally active variants in the pathophysiology of BPAD. (C) 2009 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 985-2-035-39
项目资助者: Chinese Ministry of Education ; New York State Office of Mental Retardation and Developmental Disabilities
WOS记录号: WOS:000269300600011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67815
Appears in Collections:基础医学院_医学遗传学系_期刊论文

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作者单位: 1.Anding Hosp, Depress Treatment Ctr, Beijing 100088, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Med Genet, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Shanghai Jiao Tong Univ, Bio X Ctr, Shanghai 200030, Peoples R China
4.New York State Inst Basic Res Dev Disabil, Staten Isl, NY 10314 USA

Recommended Citation:
He, Bing,Li, Junyan,Wang, Gang,et al. Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2009,33(6):986-990.
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