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学科主题: 基础医学
题名:
No association between EGF+61 A/G polymorphism and increased risk of glioma
作者: Liu, Xiaoqian2; Li, Li2; Chen, Xiangmei1; Wang, Xuefeng2; Mu, Luyan2; Li, Yajuan1; Xu, Qiang1; Xie, Qing1; Lu, Fengmin1
关键词: Epidermal growth factor ; 5 &prime ; -untranslated region ; Glioma ; Polymorphism
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
发表日期: 2009-04-01
卷: 24, 期:2, 页:77-82
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Oncology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Oncology
关键词[WOS]: EPIDERMAL-GROWTH-FACTOR ; FUNCTIONAL POLYMORPHISM ; GASTRIC-CANCER ; GENE ; MECHANISMS ; CELLS ; GLIOBLASTOMA ; PROGRESSION ; CARCINOMA ; PROMOTER
英文摘要:

A single nucleotide polymorphism (SNP) of the epidermal growth factor (EGF) gene +61 A/G in the 5′-untranslated region has been reported to be associated with susceptibility to glioma. A case-control study (1168 glioma patients and 194 normal controls) was conducted to elucidate its possible association with the risk of glioma in the Chinese population. Polymerase chain reaction-restriction fragment length polymorphism assay was used to analyze the EGF genotypes. The genotyping results were further confirmed by direct sequencing. The EGF +61 A and +61 G allele frequencies in the glioma group were 32.1% and 67.9%, respectively, while they were 30.4% and 69.6% in the healthy controls. Furthermore, the frequency of the A/A, A/G and G/G genotypes in glioma patients was 8.9%, 46.4%, and 44.7%, respectively, and 8.3%, 44.3%, and 47.4% in controls. There was no significant difference between patients and healthy controls. The EGF +61 A/G and +61 G/G genotypes were not significantly associated with risk of glioma compared with the A/A genotype. In addition, no significant association was observed between EGF polymorphism and different histological grades of glioma. These results indicate that the EGF +61 A/G polymorphism is not associated with susceptibility to glioma in the Chinese population. In addition, a literature review revealed a significantly higher rate of the A/A genotype in Caucasian compared with East Asian subjects. Such differences in genotype distribution between Caucasian and Asian people should be taken into account in future studies. (Int J Biol Markers 2009; 24: 77-82)

语种: 英语
所属项目编号: 30771099
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000270156400003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67819
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Harbin Med Coll, Affiliated Hosp 4, Harbin, Heilongjiang, Peoples R China

Recommended Citation:
Liu, Xiaoqian,Li, Li,Chen, Xiangmei,et al. No association between EGF+61 A/G polymorphism and increased risk of glioma[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,2009,24(2):77-82.
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