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学科主题: 临床医学
题名:
alpha-2-HS-glycoprotein is a potential marker predicting hepatitis B e antigen seroconversion in patients with chronic hepatitis B during treatment with pegylated interferon alfa-2b
作者: Ma Hui; Wang JiangHua; Guo Fang; Wei Lai
关键词: alpha-2-HS-glycoprotein ; pegylated interferon alfa-2b ; chronic hepatitis B
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2011
DOI: 10.1007/s11427-010-4111-4
卷: 54, 期:1, 页:39-47
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; PROTEOMIC ANALYSIS ; INSULIN-RECEPTOR ; CONTROLLED TRIAL ; TYROSINE KINASE ; GROWTH-FACTOR ; CIRRHOSIS ; LIVER ; SERUM ; IDENTIFICATION
英文摘要:

The efficacy of interferon (IFN) is limited in about 1/3 of patients with chronic hepatitis B (CHB). We used two-dimensional electrophoresis (2-DE)-based proteomic strategies to identify potential serum markers predicting hepatitis B e antigen (HBeAg) seroconversion in these patients during IFN therapy. Two groups of patients were enrolled: training and validation. In the training group, 2-DE experiments and subsequent identification of altered levels of proteins showed that alpha-2-HS-glycoprotein, leucine-rich alpha-2-glycoprotein, and haptoglobin were significantly upregulated as compared with baseline levels in the HBeAg seroconversion group, whereas apolipoprotein C-III precursor, leucine-rich alpha-2-glycoprotein, and alpha-albumin were downregulated in the non-seroconversion group. For patients with HBeAg seroconversion in the training group, Western blot analyses showed that alpha-2-HS-glycoprotein levels in 75% of patients were significantly upregulated at the end of the treatment as compared with baseline levels. Subsequent experiments in the validation group showed that alpha-2-HS-glycoprotein levels were significantly increased at week 4 in 83.33% of patients in the HBeAg seroconversion group. Dynamic changes in the serum level of alpha-2-HS-glycoprotein may be a potential early marker for predicting HBeAg seroconversion during IFN treatment for CHB.

语种: 英语
所属项目编号: 2005CB522902 ; 2007CB512900 ; 2006AA02A410 ; 30901256 ; 7102153 ; 2008ZX10002-012 ; 2008ZX10002-013 ; RDC 2009-13
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Science and Technology Major Project for Infectious Diseases Control ; Peking University People&prime ; s Hospital ; Ministry of Health of China
WOS记录号: WOS:000286470400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67821
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Ma Hui,Wang JiangHua,Guo Fang,et al. alpha-2-HS-glycoprotein is a potential marker predicting hepatitis B e antigen seroconversion in patients with chronic hepatitis B during treatment with pegylated interferon alfa-2b[J]. SCIENCE CHINA-LIFE SCIENCES,2011,54(1):39-47.
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