北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所  > 期刊论文
学科主题: 临床医学
题名:
alpha-2-HS-glycoprotein is a potential marker predicting hepatitis B e antigen seroconversion in patients with chronic hepatitis B during treatment with pegylated interferon alfa-2b
作者: Ma Hui; Wang JiangHua; Guo Fang; Wei Lai
关键词: alpha-2-HS-glycoprotein ; pegylated interferon alfa-2b ; chronic hepatitis B
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2011
DOI: 10.1007/s11427-010-4111-4
卷: 54, 期:1, 页:39-47
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; PROTEOMIC ANALYSIS ; INSULIN-RECEPTOR ; CONTROLLED TRIAL ; TYROSINE KINASE ; GROWTH-FACTOR ; CIRRHOSIS ; LIVER ; SERUM ; IDENTIFICATION
英文摘要:

The efficacy of interferon (IFN) is limited in about 1/3 of patients with chronic hepatitis B (CHB). We used two-dimensional electrophoresis (2-DE)-based proteomic strategies to identify potential serum markers predicting hepatitis B e antigen (HBeAg) seroconversion in these patients during IFN therapy. Two groups of patients were enrolled: training and validation. In the training group, 2-DE experiments and subsequent identification of altered levels of proteins showed that alpha-2-HS-glycoprotein, leucine-rich alpha-2-glycoprotein, and haptoglobin were significantly upregulated as compared with baseline levels in the HBeAg seroconversion group, whereas apolipoprotein C-III precursor, leucine-rich alpha-2-glycoprotein, and alpha-albumin were downregulated in the non-seroconversion group. For patients with HBeAg seroconversion in the training group, Western blot analyses showed that alpha-2-HS-glycoprotein levels in 75% of patients were significantly upregulated at the end of the treatment as compared with baseline levels. Subsequent experiments in the validation group showed that alpha-2-HS-glycoprotein levels were significantly increased at week 4 in 83.33% of patients in the HBeAg seroconversion group. Dynamic changes in the serum level of alpha-2-HS-glycoprotein may be a potential early marker for predicting HBeAg seroconversion during IFN treatment for CHB.

语种: 英语
所属项目编号: 2005CB522902 ; 2007CB512900 ; 2006AA02A410 ; 30901256 ; 7102153 ; 2008ZX10002-012 ; 2008ZX10002-013 ; RDC 2009-13
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; National Science and Technology Major Project for Infectious Diseases Control ; Peking University People&prime ; s Hospital ; Ministry of Health of China
WOS记录号: WOS:000286470400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67821
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Ma Hui,Wang JiangHua,Guo Fang,et al. alpha-2-HS-glycoprotein is a potential marker predicting hepatitis B e antigen seroconversion in patients with chronic hepatitis B during treatment with pegylated interferon alfa-2b[J]. SCIENCE CHINA-LIFE SCIENCES,2011,54(1):39-47.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ma Hui]'s Articles
[Wang JiangHua]'s Articles
[Guo Fang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ma Hui]‘s Articles
[Wang JiangHua]‘s Articles
[Guo Fang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace