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Implantable CMOS neuro-stimulus chip for visual prosthesis
Zhang Xu1; Pei WeiHua1; Huang BeiJu1; Wang ShuJing1; Guan Ning1; Guo Kai1; Wang Yu1; Gui Qiang1; Chen Jin1; Wang Kai2; Wu HuiJuan2; Li XiaoXin2; Li Kai3; Chen HongDa1
关键词biomedical microelectronics visual prosthesis functional electrical stimulation acute animal experiment electrical evoked potential (EEP) test
刊名SCIENCE CHINA-INFORMATION SCIENCES
2011-04-01
DOI10.1007/s11432-010-4175-6
54期:4页:898-908
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Computer Science, Information Systems
研究领域[WOS]Computer Science
关键词[WOS]RETINAL PROSTHESIS ; STIMULATION ; DEVICE ; BLIND
英文摘要

A prototype chip with 2x2 pixels for implanting in blind patients affected by outer retinal degeneration is presented in this paper. This visual prosthesis chip imitates the degenerated photoreceptor cells, senses the incident light and stimulates the remaining healthy layers of retina or optic nerve. Each pixel integrates photodiode and stimulus pulse generator, converting the illumination on the eyes into 3-bit resolution bi-phasic current pulses. On-chip charge cancellation modules are used to discharge each electrode site for tissue safety. The prototype chip is designed and fabricated in 0.18-mu m N-well CMOS (complementary metal oxide semiconductor) 1P6M Mix-signal process, with a +/- 2.5 V dual voltage supply. The functionality of the fabricated chip is demonstrated on anesthetized rabbits. Neural responses in visual cortex are successfully evoked by the neuro-stimulus chip through an on-board trigger interface and flexible electrode.

语种英语
WOS记录号WOS:000289902100017
项目编号60776024 ; 60877035 ; 90820002 ; 2007AA04Z329 ; 2007AA04Z254
资助机构National Natural Science Foundation of China ; National High-Tech Research &amp ; Development Program of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67823
专题北京大学第二临床医学院_眼科
北京大学公共卫生学院_公共卫生学院
作者单位1.Chinese Acad Sci, Inst Semicond, State Key Lab Integrated Optoelect, Beijing 100083, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
3.Peking Univ, Dept Epidemiol & Biostat, Hlth Sci Ctr, Beijing 100083, Peoples R China
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Zhang Xu,Pei WeiHua,Huang BeiJu,et al. Implantable CMOS neuro-stimulus chip for visual prosthesis[J]. SCIENCE CHINA-INFORMATION SCIENCES,2011,54(4):898-908.
APA Zhang Xu.,Pei WeiHua.,Huang BeiJu.,Wang ShuJing.,Guan Ning.,...&Chen HongDa.(2011).Implantable CMOS neuro-stimulus chip for visual prosthesis.SCIENCE CHINA-INFORMATION SCIENCES,54(4),898-908.
MLA Zhang Xu,et al."Implantable CMOS neuro-stimulus chip for visual prosthesis".SCIENCE CHINA-INFORMATION SCIENCES 54.4(2011):898-908.
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