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学科主题临床医学
Interstitial permanent implantation of I-125 seeds as salvage therapy for re-recurrent rectal carcinoma
Wang, Jun Jie1; Yuan, Hui Shu2; Li, Jin Na; Jiang, Wei Juan; Jiang, Yu Liang; Tian, Su Qing
关键词I-125 seed Permanent implantation Brachytherapy Re-recurrent rectal carcinoma
刊名INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
2009-04-01
DOI10.1007/s00384-008-0628-4
24期:4页:391-399
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]INTRAOPERATIVE RADIATION-THERAPY ; COLORECTAL-CANCER ; SACRAL RESECTION ; ABDOMINOSACRAL RESECTION ; BRACHYTHERAPY ; RADIOTHERAPY ; IRRADIATION
英文摘要

To assess the feasibility, efficacy, and morbidity of I-125 seeds interstitial permanent implant as salvage therapy for re-recurrent rectal cancer.

From September 2003 to October 2007, I-125 seeds implant procedures were performed under CT or ultrasound guidance for thirteen patients with locally re-recurrent rectal carcinoma. The minimal peripheral doses (MPD) of I-125 seeds implanted ranged from 120 to 160 Gy, with a median MPD of 140 Gy to total decay. Three patients also received two to four cycles of chemotherapy after seed implantation.

After a median follow-up of 10 months (range 3-45), the pain-free interval was 0-14 months with a median of 7 months (95% CI: 3-11 months). The response rate of pain relief was 46.2% (6/13). Local control was 3-14 months with a median of 7 months (95% CI: 3.5-10.5 months). The 1- and 2-year local control rates were 14.4% and 0%, respectively. Three (23.1%) patients died of local recurrence; seven (53.8%) patients died of local recurrence and metastases; one (7.7%) patient died of metastases. Two (15.4%) patients survived to follow-up. At the time of analysis, the median survival was 10 months (95% CI: 3.9-16.1 months). The 1- and 2-year actuarial overall survival rates were 46.2% and 11.5%, respectively. Two (15.4%) patients experienced a grade 4 toxic event. Seed migration to the pelvic wall was observed in one (7.7%) patient. There was no associated neuropathy.

I-125 seed implantation is feasible, effective, and safe as a salvage or palliative treatment for patients with re-recurrent rectal cancer.

语种英语
WOS记录号WOS:000263683500005
引用统计
被引频次:40[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67828
专题北京大学第三临床医学院_肿瘤放疗科
作者单位1.Peking Univ, Hosp 3, Ctr Canc, Dept Radiat Oncol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jun Jie,Yuan, Hui Shu,Li, Jin Na,et al. Interstitial permanent implantation of I-125 seeds as salvage therapy for re-recurrent rectal carcinoma[J]. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,2009,24(4):391-399.
APA Wang, Jun Jie,Yuan, Hui Shu,Li, Jin Na,Jiang, Wei Juan,Jiang, Yu Liang,&Tian, Su Qing.(2009).Interstitial permanent implantation of I-125 seeds as salvage therapy for re-recurrent rectal carcinoma.INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,24(4),391-399.
MLA Wang, Jun Jie,et al."Interstitial permanent implantation of I-125 seeds as salvage therapy for re-recurrent rectal carcinoma".INTERNATIONAL JOURNAL OF COLORECTAL DISEASE 24.4(2009):391-399.
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