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学科主题: 临床医学
题名:
Interstitial permanent implantation of I-125 seeds as salvage therapy for re-recurrent rectal carcinoma
作者: Wang, Jun Jie1; Yuan, Hui Shu2; Li, Jin Na; Jiang, Wei Juan; Jiang, Yu Liang; Tian, Su Qing
关键词: I-125 seed ; Permanent implantation ; Brachytherapy ; Re-recurrent rectal carcinoma
刊名: INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
发表日期: 2009-04-01
DOI: 10.1007/s00384-008-0628-4
卷: 24, 期:4, 页:391-399
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: INTRAOPERATIVE RADIATION-THERAPY ; COLORECTAL-CANCER ; SACRAL RESECTION ; ABDOMINOSACRAL RESECTION ; BRACHYTHERAPY ; RADIOTHERAPY ; IRRADIATION
英文摘要:

To assess the feasibility, efficacy, and morbidity of I-125 seeds interstitial permanent implant as salvage therapy for re-recurrent rectal cancer.

From September 2003 to October 2007, I-125 seeds implant procedures were performed under CT or ultrasound guidance for thirteen patients with locally re-recurrent rectal carcinoma. The minimal peripheral doses (MPD) of I-125 seeds implanted ranged from 120 to 160 Gy, with a median MPD of 140 Gy to total decay. Three patients also received two to four cycles of chemotherapy after seed implantation.

After a median follow-up of 10 months (range 3-45), the pain-free interval was 0-14 months with a median of 7 months (95% CI: 3-11 months). The response rate of pain relief was 46.2% (6/13). Local control was 3-14 months with a median of 7 months (95% CI: 3.5-10.5 months). The 1- and 2-year local control rates were 14.4% and 0%, respectively. Three (23.1%) patients died of local recurrence; seven (53.8%) patients died of local recurrence and metastases; one (7.7%) patient died of metastases. Two (15.4%) patients survived to follow-up. At the time of analysis, the median survival was 10 months (95% CI: 3.9-16.1 months). The 1- and 2-year actuarial overall survival rates were 46.2% and 11.5%, respectively. Two (15.4%) patients experienced a grade 4 toxic event. Seed migration to the pelvic wall was observed in one (7.7%) patient. There was no associated neuropathy.

I-125 seed implantation is feasible, effective, and safe as a salvage or palliative treatment for patients with re-recurrent rectal cancer.

语种: 英语
WOS记录号: WOS:000263683500005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67828
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Ctr Canc, Dept Radiat Oncol, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Jun Jie,Yuan, Hui Shu,Li, Jin Na,et al. Interstitial permanent implantation of I-125 seeds as salvage therapy for re-recurrent rectal carcinoma[J]. INTERNATIONAL JOURNAL OF COLORECTAL DISEASE,2009,24(4):391-399.
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