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学科主题临床医学
Effects of Onion Extract on Endogenous Vascular H2S and Adrenomedulin in Rat Atherosclerosis
Li, Wei1; Tang, Chaoshu2,3; Jin, Hongfang1; Du, Junbao1,3
关键词Onion atherosclerosis hydrogen sulfide adrenomedulin
刊名CURRENT PHARMACEUTICAL BIOTECHNOLOGY
2011-09-01
12期:9页:1427-1439
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]PULMONARY BLOOD-FLOW ; SULFIDE/CYSTATHIONINE-GAMMA-LYASE ; CHOLESTEROL-FED RABBITS ; RECEPTOR-LIKE RECEPTOR ; HYDROGEN-SULFIDE ; PLASMA ADRENOMEDULLIN ; FIBRINOLYTIC-ACTIVITY ; HYPOTENSIVE PEPTIDE ; ADHESION MOLECULES ; ESSENTIAL OILS
英文摘要

Objective: This study aimed to explore the effect of onion extract on endogenous hydrogen sulfide (H2S) and adrenomedulin (ADM) and on atherosclerotic progression in rats with atherosclerosis (AS). Methods And Results: Male Sprague-Dawley rats were randomly divided into control, AS and AS+onion groups. Ultrastructure of aorta and atherosclerotic lesions both in aorta and in coronary artery were detected. Plasma and aortic H2S were detected by using a sulfide-sensitive electrode. Plasma and aortic ADM was determined with radioimmunoassay. Cystathionine-gamma-lyase (CSE), calcitonin receptor-like receptor (CRLR), receptor activity-modifying protein (RAMP(1), RAMP(2) and RAMP(3)) mRNA expressions were analysed. Glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and NO synthase (NOS) contents in plasma, SOD1, SOD2 and ICAM-1 expressions in aorta were detected. Rats in the AS group showed marked atherosclerotic lesions both in aorta and in coronary artery but decreased aortic H2S production. Decreased plasma and aortic ADM content, but increased levels of aortic CRLR, RAMP(2) and RAMP3 mRNAs were observed. Plasma GSH-PX and SOD were reduced but MDA elevated. Plasma ICAM-1 and NO contents and iNOS activity were increased. Onion extract, however, lessened atherosclerotic lesions and increased endogenous aortic H2S production, but decreased plasma ADM content, aortic ADM content and aortic CRLR, RAMP(2) and RAMP(3) mRNAs. In addition, it increased plasma GSH-PX level and SOD activities but reduced MDA; it decreased inflammatory response but increased plasma eNOS activity and NO content. Conclusions: Onion extract exerted a marked anti-atherogenic effect in association with the up-regulation of the endogenous CSE/H2S pathway but down-regulation of the ADM/CRLR family in atherosclerotic rats.

语种英语
WOS记录号WOS:000294896500016
项目编号20070001702 ; 20070001770 ; 81070111 ; 30821001 ; 30801251 ; 2011CB503P04 ; 7112130
资助机构Foundation of the Ministry of Education, People&prime ; s Republic of China ; National Natural Science Foundation of China ; Major Basic Research Development Program of People&prime ; s Republic of China ; Beijing Natural Science Foundation
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67830
专题北京大学第一临床医学院_儿科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Wei,Tang, Chaoshu,Jin, Hongfang,et al. Effects of Onion Extract on Endogenous Vascular H2S and Adrenomedulin in Rat Atherosclerosis[J]. CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2011,12(9):1427-1439.
APA Li, Wei,Tang, Chaoshu,Jin, Hongfang,&Du, Junbao.(2011).Effects of Onion Extract on Endogenous Vascular H2S and Adrenomedulin in Rat Atherosclerosis.CURRENT PHARMACEUTICAL BIOTECHNOLOGY,12(9),1427-1439.
MLA Li, Wei,et al."Effects of Onion Extract on Endogenous Vascular H2S and Adrenomedulin in Rat Atherosclerosis".CURRENT PHARMACEUTICAL BIOTECHNOLOGY 12.9(2011):1427-1439.
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