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Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice
Wan, Zhong-xiao1; Zhang, Feng1; Geng, Qian1; Wang, Pei-yu2; Zhou, Hong3; Zhang, Yu-mei1
刊名INTERNATIONAL DAIRY JOURNAL
2010-08-01
DOI10.1016/j.idairyj.2010.02.011
20期:8页:522-527
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Food Science & Technology
研究领域[WOS]Food Science & Technology
关键词[WOS]CYCLOPHOSPHAMIDE-TREATED MICE ; IMMUNE-RESPONSE ; T-CELLS ; LYMPHOCYTES ; LACTOFERRIN ; PHASE ; TRIAL ; SUPPLEMENTATION ; DISEASE ; SYSTEM
英文摘要

Female ICR mice were administered with bovine colostrum and were treated with cyclophosphamide to establish immunosuppressed status. The cytokine levels in sera and splenocyte culture supernatants and splenic T cell subpopulations were determined. Bovine colostrum substantially restored the percentage of the total T cell population (CD3+) and effector CD4+ T lymphocyte, as well as influencing the CD4:CD8 ratio in the spleen. It was effective in increasing the concentrations of interleukin (IL)-2, interferon-gamma, granulocyte-macrophage colony-stimulating factor and decreasing the levels of IL-6 in vivo and in vitro. The levels of IL-10 in splenocyte culture supernatants were increased, whereas the levels of IL-4 in splenocyte culture supernatants were dramatically decreased. Moreover, bovine colostrum was efficacious in enhancing the production of IL-1 alpha in vitro. Thus, bovine colostrum could exhibit immunoregulatory effects via modulating splenic T lymphocytes subpopulations. Bovine colostrum may have pleiotropic effects on the production of cytokines in vivo and in vitro. (C) 2010 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000279261200003
项目编号30471449 ; 30271119 ; 30671759 ; 30872115
资助机构National Natural Science Foundation of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67831
专题北京大学公共卫生学院
北京大学药学院_药剂学系
北京大学公共卫生学院_营养与食品卫生学系
作者单位1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wan, Zhong-xiao,Zhang, Feng,Geng, Qian,et al. Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice[J]. INTERNATIONAL DAIRY JOURNAL,2010,20(8):522-527.
APA Wan, Zhong-xiao,Zhang, Feng,Geng, Qian,Wang, Pei-yu,Zhou, Hong,&Zhang, Yu-mei.(2010).Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice.INTERNATIONAL DAIRY JOURNAL,20(8),522-527.
MLA Wan, Zhong-xiao,et al."Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice".INTERNATIONAL DAIRY JOURNAL 20.8(2010):522-527.
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