北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice
作者: Wan, Zhong-xiao1; Zhang, Feng1; Geng, Qian1; Wang, Pei-yu2; Zhou, Hong3; Zhang, Yu-mei1
刊名: INTERNATIONAL DAIRY JOURNAL
发表日期: 2010-08-01
DOI: 10.1016/j.idairyj.2010.02.011
卷: 20, 期:8, 页:522-527
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology
研究领域[WOS]: Food Science & Technology
关键词[WOS]: CYCLOPHOSPHAMIDE-TREATED MICE ; IMMUNE-RESPONSE ; T-CELLS ; LYMPHOCYTES ; LACTOFERRIN ; PHASE ; TRIAL ; SUPPLEMENTATION ; DISEASE ; SYSTEM
英文摘要:

Female ICR mice were administered with bovine colostrum and were treated with cyclophosphamide to establish immunosuppressed status. The cytokine levels in sera and splenocyte culture supernatants and splenic T cell subpopulations were determined. Bovine colostrum substantially restored the percentage of the total T cell population (CD3+) and effector CD4+ T lymphocyte, as well as influencing the CD4:CD8 ratio in the spleen. It was effective in increasing the concentrations of interleukin (IL)-2, interferon-gamma, granulocyte-macrophage colony-stimulating factor and decreasing the levels of IL-6 in vivo and in vitro. The levels of IL-10 in splenocyte culture supernatants were increased, whereas the levels of IL-4 in splenocyte culture supernatants were dramatically decreased. Moreover, bovine colostrum was efficacious in enhancing the production of IL-1 alpha in vitro. Thus, bovine colostrum could exhibit immunoregulatory effects via modulating splenic T lymphocytes subpopulations. Bovine colostrum may have pleiotropic effects on the production of cytokines in vivo and in vitro. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30471449 ; 30271119 ; 30671759 ; 30872115
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000279261200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67831
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Wan, Zhong-xiao,Zhang, Feng,Geng, Qian,et al. Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice[J]. INTERNATIONAL DAIRY JOURNAL,2010,20(8):522-527.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wan, Zhong-xiao]'s Articles
[Zhang, Feng]'s Articles
[Geng, Qian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wan, Zhong-xiao]‘s Articles
[Zhang, Feng]‘s Articles
[Geng, Qian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace