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学科主题: 公共卫生
题名:
Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice
作者: Wan, Zhong-xiao1; Zhang, Feng1; Geng, Qian1; Wang, Pei-yu2; Zhou, Hong3; Zhang, Yu-mei1
刊名: INTERNATIONAL DAIRY JOURNAL
发表日期: 2010-08-01
DOI: 10.1016/j.idairyj.2010.02.011
卷: 20, 期:8, 页:522-527
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology
研究领域[WOS]: Food Science & Technology
关键词[WOS]: CYCLOPHOSPHAMIDE-TREATED MICE ; IMMUNE-RESPONSE ; T-CELLS ; LYMPHOCYTES ; LACTOFERRIN ; PHASE ; TRIAL ; SUPPLEMENTATION ; DISEASE ; SYSTEM
英文摘要:

Female ICR mice were administered with bovine colostrum and were treated with cyclophosphamide to establish immunosuppressed status. The cytokine levels in sera and splenocyte culture supernatants and splenic T cell subpopulations were determined. Bovine colostrum substantially restored the percentage of the total T cell population (CD3+) and effector CD4+ T lymphocyte, as well as influencing the CD4:CD8 ratio in the spleen. It was effective in increasing the concentrations of interleukin (IL)-2, interferon-gamma, granulocyte-macrophage colony-stimulating factor and decreasing the levels of IL-6 in vivo and in vitro. The levels of IL-10 in splenocyte culture supernatants were increased, whereas the levels of IL-4 in splenocyte culture supernatants were dramatically decreased. Moreover, bovine colostrum was efficacious in enhancing the production of IL-1 alpha in vitro. Thus, bovine colostrum could exhibit immunoregulatory effects via modulating splenic T lymphocytes subpopulations. Bovine colostrum may have pleiotropic effects on the production of cytokines in vivo and in vitro. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30471449 ; 30271119 ; 30671759 ; 30872115
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000279261200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67831
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Dept Social Med & Hlth Educ, Sch Publ Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Wan, Zhong-xiao,Zhang, Feng,Geng, Qian,et al. Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice[J]. INTERNATIONAL DAIRY JOURNAL,2010,20(8):522-527.
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