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学科主题: 临床医学
题名:
Computerized Characterization of Prostate Cancer by Fractal Analysis in MR Images
作者: Lv, Dongjiao1,2; Guo, Xuemei2,3; Wang, Xiaoying2,3; Zhang, Jue1,2; Fang, Jing1,2
关键词: prostate cancer ; magnetic resonance imaging ; T2-weighted image ; fractal analysis
刊名: JOURNAL OF MAGNETIC RESONANCE IMAGING
发表日期: 2009-07-01
DOI: 10.1002/jmri.21819
卷: 30, 期:1, 页:161-168
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: MULTIPLE-SCLEROSIS LESIONS ; NEEDLE-BIOPSY ; SEGMENTATION ; ADENOCARCINOMA ; CARCINOMA ; DIMENSION ; MODEL ; QUANTIFICATION ; CLASSIFICATION ; PATTERNS
英文摘要:

Purpose: To explore the potential of computerized characterization of prostate MR images by extracting the fractal features of texture and intensity distributions as indices in the differential diagnosis of prostate cancer.

Materials and Methods: MR T2-weighted images (T2WI) of 55 patients with pathologic results detected by ultrasound guided biopsy were collected and then divided in two groups, 27 with prostate cancer (PCa) and 28 with no histological abnormality. Texture fractal dimension (TFD) and histogram fractal dimension (HFD) were calculated to analyze complexity features of regions of Interest (ROIs) selected from the peripheral zone. Two-sample t-tests were performed to evaluate group differences for both parameters. Receiver operating characteristic (ROC) analysis was used to estimate the performance of TFD and HFD for discriminating PCa.

Results: Significant differences were found in both TFID and HFD between the two patient groups. The areas under the ROC curves of TFD and HFD were 0.691 an 0.966, respectively, in distinguishing prostatic carcinoma from normal peripheral zone. As characterized by the fractal indices, cancerous prostatic tissue exhibited smoother texture and lower variation in intensity distribution than normal prostatic tissue.

Conclusion: The study suggests that TFD and HFD depict the changes in texture and intensity distribution associated with prostate cancer on T2WI. Both TFD and HFD provide promising quantitative indices for cancer identification. HFD performs better than TFD offering a more robust MR-based indicator in the diagnosis of prostatic carcinoma.

语种: 英语
所属项目编号: 2007-2006
项目资助者: Research Fund of Capital Medical Development ; Interdisciplinary Research Fund of Peking University
WOS记录号: WOS:000267452600020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67835
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Funct Imaging, Beijing 100871, Peoples R China
3.Peking Univ, Dept Radiol, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Lv, Dongjiao,Guo, Xuemei,Wang, Xiaoying,et al. Computerized Characterization of Prostate Cancer by Fractal Analysis in MR Images[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2009,30(1):161-168.
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