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学科主题: 临床医学
题名:
Acute kidney injury in Chinese patients with lupus nephritis: a large cohort study from a single center
作者: Zhu, D.; Qu, Z.; Tan, Y.; Yu, F.; Zhao, M-h
关键词: acute kidney injury ; lupus nephritis
刊名: LUPUS
发表日期: 2011-12-01
DOI: 10.1177/0961203311417035
卷: 20, 期:14, 页:1557-1565
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: ACUTE-RENAL-FAILURE ; INTRAVENOUS CYCLOPHOSPHAMIDE ; MYCOPHENOLATE-MOFETIL ; ERYTHEMATOSUS ; CLASSIFICATION ; OUTCOMES ; VASCULOPATHY ; THERAPIES ; GENDER
英文摘要:

Objective In this study we assess clinicopathologic characteristics, treatment and prognosis of acute kidney injury (AKI) in a large cohort of Chinese patients with lupus nephritis.

Methods The clinical, laboratory, renal histopathology, treatment and outcome data were retrospectively collected and compared between lupus nephritis patients with and without AKI. The impact of AKI on renal outcome was evaluated.

Results Among 322 patients with renal biopsy-proven lupus nephritis, 66 (20.5%) were identified as AKI. Male predominance was observed in patients with AKI (p < 0.001). In comparison with the non-AKI group, patients with AKI had significantly higher proportions of serositis (p < 0.001), neurologic disorder (p = 0.026), anemia (p < 0.001), thrombocytopenia (p = 0.013) and nephrotic syndrome (p = 0.011), but significant lower serum C3 (p < 0.001). The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores, renal pathological activity indices and chronicity indices were significantly higher in the AKI group (p < 0.001 in all cases). Regarding outcome, the AKI group had a significantly poorer renal outcome compared with non-AKI group (p < 0.001). In the AKI group, patients with crescentic glomerulonephritis and thrombotic microangiopathy had the worst renal outcome. AKI was an independent risk factor for renal outcome (hazard ratio [HR] = 5.819, 95% confidence interval 2.411-14.044, p < 0.001).

Conclusions AKI is common in lupus nephritis and is an independent risk factor for renal outcome.

语种: 英语
所属项目编号: 81021004 ; BMU20100013 ; 7102150
项目资助者: National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; Beijing Natural Science Foundation
WOS记录号: WOS:000297478800015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67839
Appears in Collections:北京大学第一临床医学院_大内科_期刊论文

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作者单位: Peking Univ, Dept Med, Hosp 1,Renal Div, Key Lab Renal Dis,Inst Nephrol,Minist Hlth China, Beijing 100034, Peoples R China

Recommended Citation:
Zhu, D.,Qu, Z.,Tan, Y.,et al. Acute kidney injury in Chinese patients with lupus nephritis: a large cohort study from a single center[J]. LUPUS,2011,20(14):1557-1565.
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