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Acute kidney injury in Chinese patients with lupus nephritis: a large cohort study from a single center
Zhu, D.; Qu, Z.; Tan, Y.; Yu, F.; Zhao, M-h
关键词acute kidney injury lupus nephritis
刊名LUPUS
2011-12-01
DOI10.1177/0961203311417035
20期:14页:1557-1565
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]ACUTE-RENAL-FAILURE ; INTRAVENOUS CYCLOPHOSPHAMIDE ; MYCOPHENOLATE-MOFETIL ; ERYTHEMATOSUS ; CLASSIFICATION ; OUTCOMES ; VASCULOPATHY ; THERAPIES ; GENDER
英文摘要

Objective In this study we assess clinicopathologic characteristics, treatment and prognosis of acute kidney injury (AKI) in a large cohort of Chinese patients with lupus nephritis.

Methods The clinical, laboratory, renal histopathology, treatment and outcome data were retrospectively collected and compared between lupus nephritis patients with and without AKI. The impact of AKI on renal outcome was evaluated.

Results Among 322 patients with renal biopsy-proven lupus nephritis, 66 (20.5%) were identified as AKI. Male predominance was observed in patients with AKI (p < 0.001). In comparison with the non-AKI group, patients with AKI had significantly higher proportions of serositis (p < 0.001), neurologic disorder (p = 0.026), anemia (p < 0.001), thrombocytopenia (p = 0.013) and nephrotic syndrome (p = 0.011), but significant lower serum C3 (p < 0.001). The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores, renal pathological activity indices and chronicity indices were significantly higher in the AKI group (p < 0.001 in all cases). Regarding outcome, the AKI group had a significantly poorer renal outcome compared with non-AKI group (p < 0.001). In the AKI group, patients with crescentic glomerulonephritis and thrombotic microangiopathy had the worst renal outcome. AKI was an independent risk factor for renal outcome (hazard ratio [HR] = 5.819, 95% confidence interval 2.411-14.044, p < 0.001).

Conclusions AKI is common in lupus nephritis and is an independent risk factor for renal outcome.

语种英语
WOS记录号WOS:000297478800015
项目编号81021004 ; BMU20100013 ; 7102150
资助机构National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; Beijing Natural Science Foundation
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67839
专题北京大学第一临床医学院_大内科
北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Dept Med, Hosp 1,Renal Div, Key Lab Renal Dis,Inst Nephrol,Minist Hlth China, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhu, D.,Qu, Z.,Tan, Y.,et al. Acute kidney injury in Chinese patients with lupus nephritis: a large cohort study from a single center[J]. LUPUS,2011,20(14):1557-1565.
APA Zhu, D.,Qu, Z.,Tan, Y.,Yu, F.,&Zhao, M-h.(2011).Acute kidney injury in Chinese patients with lupus nephritis: a large cohort study from a single center.LUPUS,20(14),1557-1565.
MLA Zhu, D.,et al."Acute kidney injury in Chinese patients with lupus nephritis: a large cohort study from a single center".LUPUS 20.14(2011):1557-1565.
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