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学科主题临床医学
Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung
Chen, Ya-Hong2; Wang, Pei-Pei2; Wang, Xin-Mao2; He, Yan-Jing2; Yao, Wan-Zhen2; Qi, Yong-Fen1,3; Tang, Chao-Shu1,3
关键词Hydrogen sulfide Chronic obstructive pulmonary disease Airway smooth muscle Airway hyper-responsiveness Airway inflammation
刊名CYTOKINE
2011-03-01
DOI10.1016/j.cyto.2010.12.006
53期:3页:334-341
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Immunology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Immunology
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; SMOOTH-MUSCLE RELAXANT ; INHIBITOR ; HYPERRESPONSIVENESS ; METHACHOLINE ; CELLS ; COPD ; H2S
英文摘要

Hydrogen sulfide (H2S), recently considered the third endogenous gaseous transmitter, may have an important role in systemic inflammation. We investigated whether endogenous H2S may be a crucial mediator in airway responsiveness and airway inflammation in a rat model of chronic exposure to cigarette smoke (CS). Rats randomly divided into control and CS-exposed groups were treated with or without sodium hydrosulfide (NaHS, donor of H2S) or propargylglycine (PPG, inhibitor of cystathionine-gamma-lyase [CSE], an H2S-synthesizing enzyme) for 4-month exposure. Serum H2S level and CSE protein expression in lung tissue were higher, by 2.04- and 2.33-fold, respectively, in CS-exposed rats than in controls (P < 0.05). Exogenous administration of NaHS to CS-exposed rats alleviated airway reactivity induced by acetylcholine (Ach) or potassium chloride (KCl) by 17.4% and 13.8%, respectively, decreased lung pathology score by 32.7%, inhibited IL-8 and TNF- alpha concentrations in lung tissue by 34.2% and 31.4%, respectively, as compared with CS-exposed rats (all P < 0.05). However, blocking endogenous CSE with PPG in CS-exposed rats increased airway reactivity induced by Ach or KCl, by 24.1% and 24.5%, respectively, and aggravated lung pathology score, by 44.8%, as compared with CS-exposed rats (all P < 0.01). Incubation in vitro with NaHS, 1-3 mmol/L, relaxed rat tracheal smooth muscle precontracted by Ach or KCl. However, the NaHS-induced relaxation was not blocked by glibenclamide (10(-4) mol/L), L-NAME (10(-4) mol/L), or ODQ (1 mu mol/L) or denudation of epithelium. Endogenous H2S may have a protective role of anti-inflammation and bronchodilation in chronic CS-induced pulmonary injury. (c) 2010 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000287840200013
项目编号30871127 ; NCET-06-0003 ; 985-2-082-113 ; 2006CB503807
资助机构National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; State Major Basic Research Development Program of the People&prime ; s Republic of China
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67840
专题北京大学第三临床医学院_呼吸科
北京大学第三临床医学院_运动医学研究所
作者单位1.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Resp Dept, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Lab Cardiovasc Bioact Mol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Ya-Hong,Wang, Pei-Pei,Wang, Xin-Mao,et al. Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung[J]. CYTOKINE,2011,53(3):334-341.
APA Chen, Ya-Hong.,Wang, Pei-Pei.,Wang, Xin-Mao.,He, Yan-Jing.,Yao, Wan-Zhen.,...&Tang, Chao-Shu.(2011).Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung.CYTOKINE,53(3),334-341.
MLA Chen, Ya-Hong,et al."Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung".CYTOKINE 53.3(2011):334-341.
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