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学科主题: 临床医学
题名:
Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung
作者: Chen, Ya-Hong2; Wang, Pei-Pei2; Wang, Xin-Mao2; He, Yan-Jing2; Yao, Wan-Zhen2; Qi, Yong-Fen1,3; Tang, Chao-Shu1,3
关键词: Hydrogen sulfide ; Chronic obstructive pulmonary disease ; Airway smooth muscle ; Airway hyper-responsiveness ; Airway inflammation
刊名: CYTOKINE
发表日期: 2011-03-01
DOI: 10.1016/j.cyto.2010.12.006
卷: 53, 期:3, 页:334-341
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Immunology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology ; Immunology
关键词[WOS]: OBSTRUCTIVE PULMONARY-DISEASE ; SMOOTH-MUSCLE RELAXANT ; INHIBITOR ; HYPERRESPONSIVENESS ; METHACHOLINE ; CELLS ; COPD ; H2S
英文摘要:

Hydrogen sulfide (H2S), recently considered the third endogenous gaseous transmitter, may have an important role in systemic inflammation. We investigated whether endogenous H2S may be a crucial mediator in airway responsiveness and airway inflammation in a rat model of chronic exposure to cigarette smoke (CS). Rats randomly divided into control and CS-exposed groups were treated with or without sodium hydrosulfide (NaHS, donor of H2S) or propargylglycine (PPG, inhibitor of cystathionine-gamma-lyase [CSE], an H2S-synthesizing enzyme) for 4-month exposure. Serum H2S level and CSE protein expression in lung tissue were higher, by 2.04- and 2.33-fold, respectively, in CS-exposed rats than in controls (P < 0.05). Exogenous administration of NaHS to CS-exposed rats alleviated airway reactivity induced by acetylcholine (Ach) or potassium chloride (KCl) by 17.4% and 13.8%, respectively, decreased lung pathology score by 32.7%, inhibited IL-8 and TNF- alpha concentrations in lung tissue by 34.2% and 31.4%, respectively, as compared with CS-exposed rats (all P < 0.05). However, blocking endogenous CSE with PPG in CS-exposed rats increased airway reactivity induced by Ach or KCl, by 24.1% and 24.5%, respectively, and aggravated lung pathology score, by 44.8%, as compared with CS-exposed rats (all P < 0.01). Incubation in vitro with NaHS, 1-3 mmol/L, relaxed rat tracheal smooth muscle precontracted by Ach or KCl. However, the NaHS-induced relaxation was not blocked by glibenclamide (10(-4) mol/L), L-NAME (10(-4) mol/L), or ODQ (1 mu mol/L) or denudation of epithelium. Endogenous H2S may have a protective role of anti-inflammation and bronchodilation in chronic CS-induced pulmonary injury. (c) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30871127 ; NCET-06-0003 ; 985-2-082-113 ; 2006CB503807
项目资助者: National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; State Major Basic Research Development Program of the People&prime ; s Republic of China
WOS记录号: WOS:000287840200013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67840
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Resp Dept, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Lab Cardiovasc Bioact Mol, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Ya-Hong,Wang, Pei-Pei,Wang, Xin-Mao,et al. Involvement of endogenous hydrogen sulfide in cigarette smoke-induced changes in airway responsiveness and inflammation of rat lung[J]. CYTOKINE,2011,53(3):334-341.
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