北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所  > 期刊论文
学科主题: 临床医学
题名:
Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C
作者: Xiu, Bing-Shui1; Feng, Xiao-Yan1; He, Jing1; Wang, Guo-Hua1; Zhang, Xiang-Ying2; Zhang, He-Qiu1; Song, Xiao-Guo1; Chen, Kun1; Ling, Shi-Gan1; Zhu, Cui-Xia1; Wei, Lai3; Rao, Hui-Ying3
关键词: Hepatitis C virus ; Hypervariable region 1 ; Cross-reactivity
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2010-09-21
DOI: 10.3748/wjg.v16.i35.4460
卷: 16, 期:35, 页:4460-4466
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: HYPERVARIABLE REGION 1 ; NEUTRALIZING ANTIBODY ; EVOLUTIONARY DYNAMICS ; CHRONIC INFECTION ; LIVER-DISEASE ; VIRUS ; SEQUENCE ; VARIANTS ; PROGRESSION ; DIVERSITY
英文摘要:

AIM To evaluate the presence and cross-reactive antibodies against hypervariable region 1 (HVR1) in hepatitis C virus (HCV) infected patients and its relationship with the progression of the disease

METHODS Sixteen representative HVR1 proteins selected from a unique set of 1600 natural sequences were used to semiquantitate the cross-reactivity of HVR1 antibodies in the sera of HCV patients Fifty-five chronic HCV patients including 23 with asymptomatic mild hepatitis, 18 with chronic hepatitis and 16 with liver cirrhosis patients were studied

RESULTS The degree of the cross-reactivity of anti-HVR1 antibodies in 23 patients with mild asymptomatic hepatitis was 3 09 +/- 2 68, which was significantly lower than in those with chronic hepatitis (5 44 +/- 3 93, P < 0 05) and liver cirrhosis (7 44 +/- 3 90, P < 0 01) No correlation was observed between the broadness of the cross-reactivity anti-HVR1 antibodies and patient′s age, infection time, serum alanine aminotransferase activity, or serum HCV-RNA concentration It was the breath of cross-reactivity rather than the presence of anti-HVR1 antibody in HCV sera that was associated with the progression of liver disease

CONCLUSION The broadly cross-reactive HVR1 antibodies generated in natural HCV patients can not neutralize the virus, which results in persistent infection in patients with chronic hepatitis (C) 2010 Baishideng All rights reserved

语种: 英语
所属项目编号: 30500476 ; 2008AA02Z434 ; 2008ZX10002-013 ; 2009ZX09103-621 ; 7082048
项目资助者: The National Natural Science Foundation of China ; The National High-Tech Science Foundation of China ; National S and T Major Projects for Infectious Disease Control ; Beijing Natural Science Foundation
WOS记录号: WOS:000284494200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67841
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Acad Mil Med Sci, Inst Basic Med Sci, Beijing 100850, Peoples R China
2.Natl Inst Control Pharmaceut & Biol Prod, Beijing 100050, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Xiu, Bing-Shui,Feng, Xiao-Yan,He, Jing,et al. Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(35):4460-4466.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xiu, Bing-Shui]'s Articles
[Feng, Xiao-Yan]'s Articles
[He, Jing]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xiu, Bing-Shui]‘s Articles
[Feng, Xiao-Yan]‘s Articles
[He, Jing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace