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学科主题: 临床医学
题名:
Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C
作者: Xiu, Bing-Shui1; Feng, Xiao-Yan1; He, Jing1; Wang, Guo-Hua1; Zhang, Xiang-Ying2; Zhang, He-Qiu1; Song, Xiao-Guo1; Chen, Kun1; Ling, Shi-Gan1; Zhu, Cui-Xia1; Wei, Lai3; Rao, Hui-Ying3
关键词: Hepatitis C virus ; Hypervariable region 1 ; Cross-reactivity
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2010-09-21
DOI: 10.3748/wjg.v16.i35.4460
卷: 16, 期:35, 页:4460-4466
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: HYPERVARIABLE REGION 1 ; NEUTRALIZING ANTIBODY ; EVOLUTIONARY DYNAMICS ; CHRONIC INFECTION ; LIVER-DISEASE ; VIRUS ; SEQUENCE ; VARIANTS ; PROGRESSION ; DIVERSITY
英文摘要:

AIM To evaluate the presence and cross-reactive antibodies against hypervariable region 1 (HVR1) in hepatitis C virus (HCV) infected patients and its relationship with the progression of the disease

METHODS Sixteen representative HVR1 proteins selected from a unique set of 1600 natural sequences were used to semiquantitate the cross-reactivity of HVR1 antibodies in the sera of HCV patients Fifty-five chronic HCV patients including 23 with asymptomatic mild hepatitis, 18 with chronic hepatitis and 16 with liver cirrhosis patients were studied

RESULTS The degree of the cross-reactivity of anti-HVR1 antibodies in 23 patients with mild asymptomatic hepatitis was 3 09 +/- 2 68, which was significantly lower than in those with chronic hepatitis (5 44 +/- 3 93, P < 0 05) and liver cirrhosis (7 44 +/- 3 90, P < 0 01) No correlation was observed between the broadness of the cross-reactivity anti-HVR1 antibodies and patient′s age, infection time, serum alanine aminotransferase activity, or serum HCV-RNA concentration It was the breath of cross-reactivity rather than the presence of anti-HVR1 antibody in HCV sera that was associated with the progression of liver disease

CONCLUSION The broadly cross-reactive HVR1 antibodies generated in natural HCV patients can not neutralize the virus, which results in persistent infection in patients with chronic hepatitis (C) 2010 Baishideng All rights reserved

语种: 英语
所属项目编号: 30500476 ; 2008AA02Z434 ; 2008ZX10002-013 ; 2009ZX09103-621 ; 7082048
项目资助者: The National Natural Science Foundation of China ; The National High-Tech Science Foundation of China ; National S and T Major Projects for Infectious Disease Control ; Beijing Natural Science Foundation
WOS记录号: WOS:000284494200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67841
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Acad Mil Med Sci, Inst Basic Med Sci, Beijing 100850, Peoples R China
2.Natl Inst Control Pharmaceut & Biol Prod, Beijing 100050, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Xiu, Bing-Shui,Feng, Xiao-Yan,He, Jing,et al. Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(35):4460-4466.
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