学科主题临床医学
Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C
Xiu, Bing-Shui1; Feng, Xiao-Yan1; He, Jing1; Wang, Guo-Hua1; Zhang, Xiang-Ying2; Zhang, He-Qiu1; Song, Xiao-Guo1; Chen, Kun1; Ling, Shi-Gan1; Zhu, Cui-Xia1; Wei, Lai3; Rao, Hui-Ying3
关键词Hepatitis C virus Hypervariable region 1 Cross-reactivity
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2010-09-21
DOI10.3748/wjg.v16.i35.4460
16期:35页:4460-4466
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]HYPERVARIABLE REGION 1 ; NEUTRALIZING ANTIBODY ; EVOLUTIONARY DYNAMICS ; CHRONIC INFECTION ; LIVER-DISEASE ; VIRUS ; SEQUENCE ; VARIANTS ; PROGRESSION ; DIVERSITY
英文摘要

AIM To evaluate the presence and cross-reactive antibodies against hypervariable region 1 (HVR1) in hepatitis C virus (HCV) infected patients and its relationship with the progression of the disease

METHODS Sixteen representative HVR1 proteins selected from a unique set of 1600 natural sequences were used to semiquantitate the cross-reactivity of HVR1 antibodies in the sera of HCV patients Fifty-five chronic HCV patients including 23 with asymptomatic mild hepatitis, 18 with chronic hepatitis and 16 with liver cirrhosis patients were studied

RESULTS The degree of the cross-reactivity of anti-HVR1 antibodies in 23 patients with mild asymptomatic hepatitis was 3 09 +/- 2 68, which was significantly lower than in those with chronic hepatitis (5 44 +/- 3 93, P < 0 05) and liver cirrhosis (7 44 +/- 3 90, P < 0 01) No correlation was observed between the broadness of the cross-reactivity anti-HVR1 antibodies and patient′s age, infection time, serum alanine aminotransferase activity, or serum HCV-RNA concentration It was the breath of cross-reactivity rather than the presence of anti-HVR1 antibody in HCV sera that was associated with the progression of liver disease

CONCLUSION The broadly cross-reactive HVR1 antibodies generated in natural HCV patients can not neutralize the virus, which results in persistent infection in patients with chronic hepatitis (C) 2010 Baishideng All rights reserved

语种英语
WOS记录号WOS:000284494200014
项目编号30500476 ; 2008AA02Z434 ; 2008ZX10002-013 ; 2009ZX09103-621 ; 7082048
资助机构The National Natural Science Foundation of China ; The National High-Tech Science Foundation of China ; National S and T Major Projects for Infectious Disease Control ; Beijing Natural Science Foundation
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67841
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Acad Mil Med Sci, Inst Basic Med Sci, Beijing 100850, Peoples R China
2.Natl Inst Control Pharmaceut & Biol Prod, Beijing 100050, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Xiu, Bing-Shui,Feng, Xiao-Yan,He, Jing,et al. Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2010,16(35):4460-4466.
APA Xiu, Bing-Shui.,Feng, Xiao-Yan.,He, Jing.,Wang, Guo-Hua.,Zhang, Xiang-Ying.,...&Rao, Hui-Ying.(2010).Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C.WORLD JOURNAL OF GASTROENTEROLOGY,16(35),4460-4466.
MLA Xiu, Bing-Shui,et al."Evaluation of cross-reactive antibody response to HVR1 in chronic hepatitis C".WORLD JOURNAL OF GASTROENTEROLOGY 16.35(2010):4460-4466.
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