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N-alpha-acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28 beta
Min, Li1; Xu, Huiyu1; Wang, Juan2; Qu, Like1; Jiang, Beihai1; Zeng, Yan1; Meng, Lin1; Jin, Hongwei3; Shou, Chengchao1
关键词Naa10p PA28 beta Proteasome activity
刊名FEBS LETTERS
2013-06-05
DOI10.1016/j.febslet.2013.04.016
587期:11页:1630-1637
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]CANCER-CELL-PROLIFERATION ; TERMINAL ACETYLTRANSFERASES ; SIGNALING PATHWAY ; 20S PROTEASOME ; BETA-CATENIN ; ACETYLATION ; EXPRESSION ; COMPLEX ; ACTIVATION ; APOPTOSIS
英文摘要

N-alpha-acetyltransferase 10 protein (Naa10p) regulates various pathways associated with cancer cell proliferation, metastasis, apoptosis and autophagy. However, its role in protein quality control is unknown. Here, we report that Naa10p is physically associated with proteasome activator 28 beta (PA28 beta). Naa10p also interacts with PA28 alpha in a PA28 beta-dependent manner. Naa10p negatively regulates PA28-dependent chymotrypsin-like proteasome activity in cancer cells and in a cell-free system reconstituted with purified proteins, which is not related to 26S proteasome. Acetyltransferase activity of Naa10p is not required for its effect on chymotrypsin-like proteasome activity. Therefore, our data reveal that Naa10p suppresses 28S proteasome activity through interaction with PA28 beta.

Structured summary of protein interactions:

Naa10p physically interacts with PA28 alpha and PA28 beta by anti bait coimmunoprecipitation (View Interaction: 1, 2) (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000319445900008
项目编号20110001110050 ; 2009CB521805 ; 81071658
资助机构Research Fund for the Doctoral Program of Higher Education of China ; National 973 Program of China ; National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67842
专题北京大学基础医学院_医学信息学系
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学第三临床医学院_妇产科
北京大学临床肿瘤学院_生化与分子生物学研究室
作者单位1.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Biochem & Mol Biol, Beijing 100142, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Min, Li,Xu, Huiyu,Wang, Juan,et al. N-alpha-acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28 beta[J]. FEBS LETTERS,2013,587(11):1630-1637.
APA Min, Li.,Xu, Huiyu.,Wang, Juan.,Qu, Like.,Jiang, Beihai.,...&Shou, Chengchao.(2013).N-alpha-acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28 beta.FEBS LETTERS,587(11),1630-1637.
MLA Min, Li,et al."N-alpha-acetyltransferase 10 protein is a negative regulator of 28S proteasome through interaction with PA28 beta".FEBS LETTERS 587.11(2013):1630-1637.
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