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Impact of L-arginine on hydrogen sulfide/cystathionine-gamma-lyase pathway in rats with high blood flow-induced pulmonary hypertension
Wang, YF; Shi, L; Du, JB; Tang, CS
关键词hydrogen sulfide L-arginine pulmonary hypertension high pulmonary blood flow
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2006-06-30
DOI10.1016/j.bbrc.2006.04.162
345期:2页:851-857
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]CONGENITAL HEART-DISEASE ; NITRIC-OXIDE SYNTHASE ; COMPETITIVE PCR ; SULFIDE ; PATHOGENESIS ; CHILDREN ; H2S
英文摘要

The present study was designed to explore the possible effect Of L-arginine on endogenous hydrogen sulfide/cystathionine-gamma-lyase (H2S/CSE) pathway in the pathogenesis of pulmonary hypertension and pulmonary vascular structural remodeling induced by high pulmonary blood flow. Thirty-two male Sprague-Dawley rats were randomly divided into control group (n = 11) Shunt group (n = 11) and shunt with L-arginine group (n = 10). Rats in the shunt and Shunt with L-arginine group underwent an abdominal aorta-inferior cava vein shunt operation. After 11 weeks of shunting, the plasma level of H,S and lung tissue H,S production rate in the Shunt with L-arginine group were much higher than those in the shunt group (P < 0.01). Meanwhile, the expression of CSE mRNA in the lung tissues of rats in the shunt with L-arginine group was increased significantly (P < 0.01), and in situ hybridization showed that CSE mRNA expression was obviously up-regulated in the smooth muscle cells (SMCs) of the pulmonary arteries of shunted rats treated with L-arginine when compared with shunted rats without the treatment Of L-arginine (P < 0.01). In conclusion, H2S/CSE pathway was up-regulated by L-arginine in pulmonary hypertension induced by high blood flow with the attenuation of pulmonary hypertension and pulmonary vascular structural remodeling. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000238001600043
引用统计
被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67846
专题北京大学第一临床医学院_儿科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Dis, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, YF,Shi, L,Du, JB,et al. Impact of L-arginine on hydrogen sulfide/cystathionine-gamma-lyase pathway in rats with high blood flow-induced pulmonary hypertension[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,345(2):851-857.
APA Wang, YF,Shi, L,Du, JB,&Tang, CS.(2006).Impact of L-arginine on hydrogen sulfide/cystathionine-gamma-lyase pathway in rats with high blood flow-induced pulmonary hypertension.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,345(2),851-857.
MLA Wang, YF,et al."Impact of L-arginine on hydrogen sulfide/cystathionine-gamma-lyase pathway in rats with high blood flow-induced pulmonary hypertension".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 345.2(2006):851-857.
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