IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration
Guo, Xiao-Kai; Liu, Yuan-Feng; Zhou, Yu; Sun, Xiu-Yuan; Qian, Xiao-Ping; Zhang, Yu; Zhang, Jun
刊名CLINICAL & DEVELOPMENTAL IMMUNOLOGY
2013
DOI10.1155/2013/462152
0
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]T-CELL DEVELOPMENT ; EXTRACELLULAR-MATRIX ; IN-VIVO ; RECEPTOR ; FIBRONECTIN ; ACTIVATION ; INDUCTION ; INTEGRINS ; DIFFERENTIATION ; ALPHA-3-BETA-1
英文摘要

Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyte development is still unknown. Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment. Importantly, Netrin-1 mediates the adhesion of thymocytes, and this effect is comparable to or greater than that of fibronectin. Furthermore, Netrin-1 specifically promotes the chemotaxis of CXCL12. These suggest that Netrin-1 may play an important role in thymocyte development.

语种英语
WOS记录号WOS:000327975500001
项目编号2011CB946103 ; 2010CB945300 ; 81072395
资助机构National Basic Research Program of China ; National Natural Science Foundation of China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67851
专题北京大学基础医学院_免疫学系
北京大学基础医学院
作者单位Peking Univ, Key Lab Med Immunol, Sch Basic Med Sci, Dept Immunol,Minist Hlth,Hlth Sci Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Guo, Xiao-Kai,Liu, Yuan-Feng,Zhou, Yu,et al. The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration[J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY,2013(0).
APA Guo, Xiao-Kai.,Liu, Yuan-Feng.,Zhou, Yu.,Sun, Xiu-Yuan.,Qian, Xiao-Ping.,...&Zhang, Jun.(2013).The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration.CLINICAL & DEVELOPMENTAL IMMUNOLOGY(0).
MLA Guo, Xiao-Kai,et al."The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration".CLINICAL & DEVELOPMENTAL IMMUNOLOGY .0(2013).
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