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学科主题: 基础医学
题名:
The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration
作者: Guo, Xiao-Kai; Liu, Yuan-Feng; Zhou, Yu; Sun, Xiu-Yuan; Qian, Xiao-Ping; Zhang, Yu; Zhang, Jun
刊名: CLINICAL & DEVELOPMENTAL IMMUNOLOGY
发表日期: 2013
DOI: 10.1155/2013/462152
期: 0
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: T-CELL DEVELOPMENT ; EXTRACELLULAR-MATRIX ; IN-VIVO ; RECEPTOR ; FIBRONECTIN ; ACTIVATION ; INDUCTION ; INTEGRINS ; DIFFERENTIATION ; ALPHA-3-BETA-1
英文摘要:

Netrin-1, a known axon guidance molecule, being a secreted laminin-related molecule, has been suggested to be involved in multiple physiological and pathological conditions, such as organogenesis, angiogenesis, tumorigenesis, and inflammation-mediated tissue injury. However, its function in thymocyte development is still unknown. Here, we demonstrate that Netrin-1 is expressed in mouse thymus tissue and is primarily expressed in thymic stromal cells, and the expression of Netrin-1 in thymocytes can be induced by anti-CD3 antibody or IL-7 treatment. Importantly, Netrin-1 mediates the adhesion of thymocytes, and this effect is comparable to or greater than that of fibronectin. Furthermore, Netrin-1 specifically promotes the chemotaxis of CXCL12. These suggest that Netrin-1 may play an important role in thymocyte development.

语种: 英语
所属项目编号: 2011CB946103 ; 2010CB945300 ; 81072395
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000327975500001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67851
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Peking Univ, Key Lab Med Immunol, Sch Basic Med Sci, Dept Immunol,Minist Hlth,Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Guo, Xiao-Kai,Liu, Yuan-Feng,Zhou, Yu,et al. The Expression of Netrin-1 in the Thymus and Its Effects on Thymocyte Adhesion and Migration[J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY,2013(0).
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