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学科主题临床医学
In vitro susceptibility of Escherichia coli strains isolated from urine samples obtained in mainland China to fosfomycin trometamol and other antibiotics: a 9-year surveillance study (2004-2012)
Lai, Bei1,4; Zheng, Bo2; Li, Yun2; Zhu, Sainan3; Tong, Zhaohui1
刊名BMC INFECTIOUS DISEASES
2014-02-06
DOI10.1186/1471-2334-14-66
14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]TRACT-INFECTIONS ; RESISTANCE
英文摘要

Background: As a result of extensive use of fluroquinlones and cephalosporins, urinary tract pathogens producing extended-spectrum beta-lactamase (ESBL) pose a considerable clinical challenge in the treatment of UTIs. In the present study we retrospectively assessed the susceptibility of E. coli strains to fosfomycin trometamol and other antibiotics commonly used for the treatment of such infections.

Methods: A total of 908 nonreplicate clinical E. coli urinary isolates were collected from 20 Chinese hospitals over four consecutive 1-year periods between October 2004 and June 2012. Susceptibility to antimicrobial agents fosfomycin trometamol, piperacillin-tazobactam, cefuroxime, cefotaxime, cefepime, imipenem, amikacin, levofloxacin, and nitrofurantoin was determined using the agar dilution method. A reference strain E. coli (ATCC 25922) was used as a positive control. Results were analyzed using Chi-square test or Fisher′s exact tests.

Results: Fosfomycin trometamol, piperacillin-tazobactam, amikacin, and imipenem were consistently the most active agents against most of the isolates. There was a decline in susceptibility to cefuroxime, cefotaxime, and cefepime between 2004 and 2010. We showed that 528 of the 908 E. coli isolates (58.1%) produced ESBLs. The ESBL-positive rates increased from 41.7% in 2004-2005 to 60.9% in 2011-2012. ESBL-producing E. coli isolates showed significantly higher resistance rates to levofloxacin than the ESBL-negative isolates. Fosfomycin trometamol, piperacillin-tazobactam, amikacin, and imipenem had good activity against both levofloxacin-susceptible and levofloxacin-nonsusceptible isolates (sensitivity rate > 90%). However susceptibility of levofloxacin-resistant isolates to cefuroxime, cefotaxime, cefepime, amikacin, and nitrofurantoin was significantly lower than that of levofloxacin-susceptible isolates.

Conclusions: Owing to the increase in the bacterial resistance across the world, the European Urology Association has recommended fosfomycin trometamol as the drug of choice in its Guidelines on Urological Infections released in 2013. Our results confirm this recommendation for use in China and continued monitoring of the susceptibility of E. coli to fosfomycin trometamol is need with the widely use of the drug in China.

语种英语
WOS记录号WOS:000331207500005
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67852
专题北京大学第一临床医学院_临床药理研究所
北京大学第一临床医学院_医学统计室
作者单位1.Beijing Hosp, Dept Rheumatol & Immunol, Beijing 100730, Peoples R China
2.Capital Med Univ, Beijing Chaoyang Hosp, Beijing Inst Resp Med, Dept Resp & Crit Care Med, Beijing 100020, Peoples R China
3.Peking Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Biostat, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Lai, Bei,Zheng, Bo,Li, Yun,et al. In vitro susceptibility of Escherichia coli strains isolated from urine samples obtained in mainland China to fosfomycin trometamol and other antibiotics: a 9-year surveillance study (2004-2012)[J]. BMC INFECTIOUS DISEASES,2014,14.
APA Lai, Bei,Zheng, Bo,Li, Yun,Zhu, Sainan,&Tong, Zhaohui.(2014).In vitro susceptibility of Escherichia coli strains isolated from urine samples obtained in mainland China to fosfomycin trometamol and other antibiotics: a 9-year surveillance study (2004-2012).BMC INFECTIOUS DISEASES,14.
MLA Lai, Bei,et al."In vitro susceptibility of Escherichia coli strains isolated from urine samples obtained in mainland China to fosfomycin trometamol and other antibiotics: a 9-year surveillance study (2004-2012)".BMC INFECTIOUS DISEASES 14(2014).
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