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学科主题: 临床医学
题名:
Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: Synthesis, characterization, and dual nuclear/optical imaging
作者: Yang, Zhi; Zheng, Shiying; Harrison, William J.; Harder, John; Wen, Xiaoxia; Gelovani, Juri G.; Qiao, Alex; Li, Chun
刊名: BIOMACROMOLECULES
发表日期: 2007-11-01
DOI: 10.1021/bm7005399
卷: 8, 期:11, 页:3422-3428
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
关键词[WOS]: GROWTH-FACTOR RECEPTOR ; IN-VIVO ; QUANTUM DOTS ; CANCER ; NANOPARTICLES ; TOMOGRAPHY ; BIODISTRIBUTION ; CHEMOTHERAPY ; ANTIBODIES ; TUMORS
英文摘要:

We report the synthesis of PEG-coated, core-cross- linked polymeric micelles (CCPMs) derived from an amine-terminated amphiphilic block copolymer, poly(PEG-methacrylate)-b-poly(triethoxysilyl propylmethacrylate). The block copolymer self-assembled to form micellar nanoparticles, and a Cy-7-like near-infrared fluorescence (NIRF) dye was entrapped in the core bearing reactive ethoxysilane functional groups through a subsequent sol-gel process. The fluorescent signal of CCPMs on the molar basis was 16-fold brighter than that of Cy7. With an average diameter of 24 +/- 8.9 nm, CCPMs exhibited a prolonged blood half-life (t(1/2,alpha) = 1.25 h; t1/2,beta = 46.18 h) and moderate uptake by the mononuclear phagocytic system. Significant accumulation of CCPMs in human breast tumor xenografts allowed noninvasive monitoring of the uptake kinetics with both NIRF optical and gamma imaging techniques. Our data suggest that Cy7-entrapped CCPM nanoparticles are suitable for NIRF imaging of solid tumors and have potential applications in the imaging of tumor-associated molecular markers.

语种: 英语
WOS记录号: WOS:000250960300019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67856
Appears in Collections:北京大学临床肿瘤学院_核医学科_期刊论文

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作者单位: 1.Carestream Hlth Inc, Rochester, NY 14615 USA
2.Eastman Kodak Co, Res Labs, Rochester, NY 14650 USA
3.Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging Unit 59, Houston, TX 77030 USA
4.Peking Univ, Dept Nucl Med, Beijing Canc Hosp, Sch Oncol, Beijing 10036, Peoples R China

Recommended Citation:
Yang, Zhi,Zheng, Shiying,Harrison, William J.,et al. Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: Synthesis, characterization, and dual nuclear/optical imaging[J]. BIOMACROMOLECULES,2007,8(11):3422-3428.
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