IR@PKUHSC  > 北京大学临床肿瘤学院  > 核医学科
学科主题临床医学
Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: Synthesis, characterization, and dual nuclear/optical imaging
Yang, Zhi; Zheng, Shiying; Harrison, William J.; Harder, John; Wen, Xiaoxia; Gelovani, Juri G.; Qiao, Alex; Li, Chun
刊名BIOMACROMOLECULES
2007-11-01
DOI10.1021/bm7005399
8期:11页:3422-3428
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
关键词[WOS]GROWTH-FACTOR RECEPTOR ; IN-VIVO ; QUANTUM DOTS ; CANCER ; NANOPARTICLES ; TOMOGRAPHY ; BIODISTRIBUTION ; CHEMOTHERAPY ; ANTIBODIES ; TUMORS
英文摘要

We report the synthesis of PEG-coated, core-cross- linked polymeric micelles (CCPMs) derived from an amine-terminated amphiphilic block copolymer, poly(PEG-methacrylate)-b-poly(triethoxysilyl propylmethacrylate). The block copolymer self-assembled to form micellar nanoparticles, and a Cy-7-like near-infrared fluorescence (NIRF) dye was entrapped in the core bearing reactive ethoxysilane functional groups through a subsequent sol-gel process. The fluorescent signal of CCPMs on the molar basis was 16-fold brighter than that of Cy7. With an average diameter of 24 +/- 8.9 nm, CCPMs exhibited a prolonged blood half-life (t(1/2,alpha) = 1.25 h; t1/2,beta = 46.18 h) and moderate uptake by the mononuclear phagocytic system. Significant accumulation of CCPMs in human breast tumor xenografts allowed noninvasive monitoring of the uptake kinetics with both NIRF optical and gamma imaging techniques. Our data suggest that Cy7-entrapped CCPM nanoparticles are suitable for NIRF imaging of solid tumors and have potential applications in the imaging of tumor-associated molecular markers.

语种英语
WOS记录号WOS:000250960300019
引用统计
被引频次:88[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67856
专题北京大学临床肿瘤学院_核医学科
作者单位1.Carestream Hlth Inc, Rochester, NY 14615 USA
2.Eastman Kodak Co, Res Labs, Rochester, NY 14650 USA
3.Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging Unit 59, Houston, TX 77030 USA
4.Peking Univ, Dept Nucl Med, Beijing Canc Hosp, Sch Oncol, Beijing 10036, Peoples R China
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GB/T 7714
Yang, Zhi,Zheng, Shiying,Harrison, William J.,et al. Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: Synthesis, characterization, and dual nuclear/optical imaging[J]. BIOMACROMOLECULES,2007,8(11):3422-3428.
APA Yang, Zhi.,Zheng, Shiying.,Harrison, William J..,Harder, John.,Wen, Xiaoxia.,...&Li, Chun.(2007).Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: Synthesis, characterization, and dual nuclear/optical imaging.BIOMACROMOLECULES,8(11),3422-3428.
MLA Yang, Zhi,et al."Long-circulating near-infrared fluorescence core-cross-linked polymeric micelles: Synthesis, characterization, and dual nuclear/optical imaging".BIOMACROMOLECULES 8.11(2007):3422-3428.
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