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学科主题临床医学
Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer
Da, Ni1; Lu, Ai-Ping1; Shou, Cheng-Chao2; Li, Ji-You1
关键词Phosphatase regenerating liver 3 Gastric cancer Prognosis Recurrence Antibody
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2009-03-28
DOI10.3748/wjg.15.1499
15期:12页:1499-1505
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]PROTEIN-TYROSINE PHOSPHATASES ; COLORECTAL-CANCER ; PRL PHOSPHATASES ; GENE-EXPRESSION ; MONOCLONAL-ANTIBODIES ; PERITONEAL METASTASIS ; BREAST-CANCER ; ASSOCIATION ; MOTILITY ; INVASION
英文摘要

AIM: To investigate the prognostic significance of phosphatase regenerating liver 3 (PRL-3) protein expression in gastric cancer.

METHODS: PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry. Monoclonal antibody specifically against PRL-3, 3136, was obtained with hybridoma technique.

RESULTS: Positive PRL-3 expression was detected in 43.3% (127 of 293) of gastric cancer cases. High expression of PRL-3 was positively correlated with tumor size, depth of invasion, vascular/lymphatic invasion, lymph node metastasis, high TNM stage and tumor recurrence. Patients with positive PRL-3 expression had a significantly lower 5-year survival rate than those with negative expression (28.3% vs 51.9%, P < 0.0001). Patients who received curative surgery, and with positive PRL-3 expression had a significant shorter overall survival and disease-free disadvantage over patients with negative expression (hazard ratio of 16.7 and 16.6, respectively; P < 0.0001 for both). Multivariate analysis revealed that PRL-3 expression was an independent prognostic indicator for overall and disease-free survival of gastric cancer patients, particularly for survival in TNM stage 111 patients.

CONCLUSION: PRO expression is a new independent prognostic indicator to predict the potential of recurrence and survival in patients with gastric cancer at the time of tumor resection. (C) 2009 The WJG Press and Baishideng. All rights reserved.

语种英语
WOS记录号WOS:000264711700015
项目编号2002BA711A06 ; 1998051203 ; H020920030390
资助机构Ministry of Science and Technology of China ; Beijing Science and Technology Commission
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67859
专题北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_生化与分子生物学研究室
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Pathol, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Biochem & Mol Biol, Beijing 100036, Peoples R China
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GB/T 7714
Da, Ni,Lu, Ai-Ping,Shou, Cheng-Chao,et al. Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2009,15(12):1499-1505.
APA Da, Ni,Lu, Ai-Ping,Shou, Cheng-Chao,&Li, Ji-You.(2009).Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer.WORLD JOURNAL OF GASTROENTEROLOGY,15(12),1499-1505.
MLA Da, Ni,et al."Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer".WORLD JOURNAL OF GASTROENTEROLOGY 15.12(2009):1499-1505.
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