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学科主题: 临床医学
题名:
Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer
作者: Da, Ni1; Lu, Ai-Ping1; Shou, Cheng-Chao2; Li, Ji-You1
关键词: Phosphatase regenerating liver 3 ; Gastric cancer ; Prognosis ; Recurrence ; Antibody
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2009-03-28
DOI: 10.3748/wjg.15.1499
卷: 15, 期:12, 页:1499-1505
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: PROTEIN-TYROSINE PHOSPHATASES ; COLORECTAL-CANCER ; PRL PHOSPHATASES ; GENE-EXPRESSION ; MONOCLONAL-ANTIBODIES ; PERITONEAL METASTASIS ; BREAST-CANCER ; ASSOCIATION ; MOTILITY ; INVASION
英文摘要:

AIM: To investigate the prognostic significance of phosphatase regenerating liver 3 (PRL-3) protein expression in gastric cancer.

METHODS: PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry. Monoclonal antibody specifically against PRL-3, 3136, was obtained with hybridoma technique.

RESULTS: Positive PRL-3 expression was detected in 43.3% (127 of 293) of gastric cancer cases. High expression of PRL-3 was positively correlated with tumor size, depth of invasion, vascular/lymphatic invasion, lymph node metastasis, high TNM stage and tumor recurrence. Patients with positive PRL-3 expression had a significantly lower 5-year survival rate than those with negative expression (28.3% vs 51.9%, P < 0.0001). Patients who received curative surgery, and with positive PRL-3 expression had a significant shorter overall survival and disease-free disadvantage over patients with negative expression (hazard ratio of 16.7 and 16.6, respectively; P < 0.0001 for both). Multivariate analysis revealed that PRL-3 expression was an independent prognostic indicator for overall and disease-free survival of gastric cancer patients, particularly for survival in TNM stage 111 patients.

CONCLUSION: PRO expression is a new independent prognostic indicator to predict the potential of recurrence and survival in patients with gastric cancer at the time of tumor resection. (C) 2009 The WJG Press and Baishideng. All rights reserved.

语种: 英语
所属项目编号: 2002BA711A06 ; 1998051203 ; H020920030390
项目资助者: Ministry of Science and Technology of China ; Beijing Science and Technology Commission
WOS记录号: WOS:000264711700015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67859
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Pathol, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp, Dept Biochem & Mol Biol, Beijing 100036, Peoples R China

Recommended Citation:
Da, Ni,Lu, Ai-Ping,Shou, Cheng-Chao,et al. Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2009,15(12):1499-1505.
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