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Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus
Zhao, Haifeng1,2; Li, Qiong1; Pei, Xinrong1; Zhang, Zhaofeng1; Yang, Ruiyue1; Wang, Junbo1; Li, Yong1
关键词Ginsenoside Hippocampus Memory Prevention Synaptic plasticity
刊名BEHAVIOURAL BRAIN RESEARCH
2009-08-12
DOI10.1016/j.bbr.2009.03.002
201期:2页:311-317
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]OXIDATIVE STRESS ; ANIMAL-MODELS ; ZINGIBER-OFFICINALE ; COGNITIVE DEFICITS ; ALZHEIMERS-DISEASE ; MAZE PERFORMANCE ; GINKGO-BILOBA ; AGING BRAIN ; FOOT-SHOCK ; NEURONS
英文摘要

Memory impairment is considered to be one of the most prominent consequences of aging. Deterioration of memory begins in advance of old age in animals, including humans. Thus, it is extremely important to prevent memory decline for increasing healthy aging. Ginsenoside, the effective ingredient of ginseng, has been reported to have a neuron beneficial effect, but the preventive role on memory impairment and the underlying mechanisms have not been well determined. In the present study, C57BL/6J mice aged 12 months were chronically treated with ginsenoside 100 mg/kg per day for 8 months. Placebo-treated aged mice, young and adult ones (4- and 8-month-old, respectively) were used as controls. The efficacious effect of ginsenoside was manifested in the amelioration of memory impairment in aged mice by Morris water maze and step-down tests. Compared with aged control group, the plasticity-related proteins including phospho-N-methyl-D-aspartate receptor1 (NMDAR1), phospho-calcium-calmodulin dependent kinase II (CaMK II), phospho-PKA catalytic beta subunit (PKA C beta), phospho-cAMP-response element binding protein (CREB) and brain derived neurotrophic factor (BDNF) in hippocampus significantly increased in ginsenoside treated group. These findings suggest that ginsenoside is effective on the prevention of age-related memory impairment, and the up-regulation of plasticity-related proteins in hippocampus may be one of the mechanisms. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000266514000011
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67862
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
北京大学公共卫生学院_公共卫生学院
作者单位1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Shanxi Med Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Taiyuan 030001, Shanxi, Peoples R China
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GB/T 7714
Zhao, Haifeng,Li, Qiong,Pei, Xinrong,et al. Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus[J]. BEHAVIOURAL BRAIN RESEARCH,2009,201(2):311-317.
APA Zhao, Haifeng.,Li, Qiong.,Pei, Xinrong.,Zhang, Zhaofeng.,Yang, Ruiyue.,...&Li, Yong.(2009).Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus.BEHAVIOURAL BRAIN RESEARCH,201(2),311-317.
MLA Zhao, Haifeng,et al."Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus".BEHAVIOURAL BRAIN RESEARCH 201.2(2009):311-317.
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