北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus
作者: Zhao, Haifeng1,2; Li, Qiong1; Pei, Xinrong1; Zhang, Zhaofeng1; Yang, Ruiyue1; Wang, Junbo1; Li, Yong1
关键词: Ginsenoside ; Hippocampus ; Memory ; Prevention ; Synaptic plasticity
刊名: BEHAVIOURAL BRAIN RESEARCH
发表日期: 2009-08-12
DOI: 10.1016/j.bbr.2009.03.002
卷: 201, 期:2, 页:311-317
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]: OXIDATIVE STRESS ; ANIMAL-MODELS ; ZINGIBER-OFFICINALE ; COGNITIVE DEFICITS ; ALZHEIMERS-DISEASE ; MAZE PERFORMANCE ; GINKGO-BILOBA ; AGING BRAIN ; FOOT-SHOCK ; NEURONS
英文摘要:

Memory impairment is considered to be one of the most prominent consequences of aging. Deterioration of memory begins in advance of old age in animals, including humans. Thus, it is extremely important to prevent memory decline for increasing healthy aging. Ginsenoside, the effective ingredient of ginseng, has been reported to have a neuron beneficial effect, but the preventive role on memory impairment and the underlying mechanisms have not been well determined. In the present study, C57BL/6J mice aged 12 months were chronically treated with ginsenoside 100 mg/kg per day for 8 months. Placebo-treated aged mice, young and adult ones (4- and 8-month-old, respectively) were used as controls. The efficacious effect of ginsenoside was manifested in the amelioration of memory impairment in aged mice by Morris water maze and step-down tests. Compared with aged control group, the plasticity-related proteins including phospho-N-methyl-D-aspartate receptor1 (NMDAR1), phospho-calcium-calmodulin dependent kinase II (CaMK II), phospho-PKA catalytic beta subunit (PKA C beta), phospho-cAMP-response element binding protein (CREB) and brain derived neurotrophic factor (BDNF) in hippocampus significantly increased in ginsenoside treated group. These findings suggest that ginsenoside is effective on the prevention of age-related memory impairment, and the up-regulation of plasticity-related proteins in hippocampus may be one of the mechanisms. (C) 2009 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2006BAD271308
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号: WOS:000266514000011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67862
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Shanxi Med Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Taiyuan 030001, Shanxi, Peoples R China

Recommended Citation:
Zhao, Haifeng,Li, Qiong,Pei, Xinrong,et al. Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus[J]. BEHAVIOURAL BRAIN RESEARCH,2009,201(2):311-317.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhao, Haifeng]'s Articles
[Li, Qiong]'s Articles
[Pei, Xinrong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhao, Haifeng]‘s Articles
[Li, Qiong]‘s Articles
[Pei, Xinrong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace