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Risperidone Maintenance Treatment in Schizophrenia: A Randomized, Controlled Trial
Wang, Chuan-Yue1; Xiang, Yu-Tao; Cai, Zhuo-Ji; Weng, Yong-Zhen; Bo, Qi-Jing; Zhao, Jing-Ping; Liu, Tie-Qiao; Wang, Gao-Hua; Weng, Shi-Min; Zhang, Hong-Yan; Chen, Da-Fang; Tang, Wai-Kwong
刊名AMERICAN JOURNAL OF PSYCHIATRY
2010-06-01
167期:6页:676-685
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]SYNDROME SCALE PANSS ; NORTH-AMERICAN ; 5 DIMENSIONS ; HALOPERIDOL ; THERAPY ; RELAPSE ; RECOMMENDATIONS ; FLUPHENAZINE ; PREVENTION ; DECANOATE
英文摘要

Objective: Prevention of relapse is the crucial task in the maintenance treatment of schizophrenia. The investigators in this study sought to determine the duration of maintenance treatment needed with the initial therapeutic dose, in contrast to a reduced dose.

Method: In a multicenter open-label, randomized, controlled study, patients with schizophrenia who were clinically stabilized following an acute episode were randomly assigned to a no-dose-reduction group (initial optimal therapeutic dose continued throughout the study), a 4-week group (initial optimal therapeutic dose continued for 4 weeks, followed by a 50% dose reduction that was maintained until the end of the study), or a 26-week group (initial optimal therapeutic dose continued for 26 weeks, followed by a 50% dose reduction until the end of the study). All patients continued until the last recruited patient completed the 1-year follow-up.

Results: Of the 404 patients who met the entry criteria and were randomly assigned, 374 completed the study. The estimated mean time from entry to relapse was 571 days in the 4-week group, 615 days in the 26-week group, and 683 days in the no-dose-reduction group, with estimated relapse rates of 30.5%, 19.5%, and 9.4%, respectively. Patients in the nodose- reduction group experienced greater reduction in the severity of psychotic symptoms.

Conclusions: Patients who continued to receive the full risperidone dose used for their acute episode had fewer relapses than those who had dose reductions after 4 weeks or 26 weeks during the maintenance period. There was negligible difference in side effects among the three groups. (Am J Psychiatry 2010;167:676-685)

语种英语
WOS记录号WOS:000278269500012
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67870
专题北京大学精神卫生研究所
作者单位1.Capital Med Univ, Lab Clin Psychopharmacol, Beijing & Hosp, Beijing 100088, Peoples R China
2.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
3.Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha 410083, Peoples R China
4.Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan 430072, Peoples R China
5.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
6.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
7.Peking Univ, Sch Publ Hlth, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Wang, Chuan-Yue,Xiang, Yu-Tao,Cai, Zhuo-Ji,et al. Risperidone Maintenance Treatment in Schizophrenia: A Randomized, Controlled Trial[J]. AMERICAN JOURNAL OF PSYCHIATRY,2010,167(6):676-685.
APA Wang, Chuan-Yue.,Xiang, Yu-Tao.,Cai, Zhuo-Ji.,Weng, Yong-Zhen.,Bo, Qi-Jing.,...&Tang, Wai-Kwong.(2010).Risperidone Maintenance Treatment in Schizophrenia: A Randomized, Controlled Trial.AMERICAN JOURNAL OF PSYCHIATRY,167(6),676-685.
MLA Wang, Chuan-Yue,et al."Risperidone Maintenance Treatment in Schizophrenia: A Randomized, Controlled Trial".AMERICAN JOURNAL OF PSYCHIATRY 167.6(2010):676-685.
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