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学科主题: 精神卫生
题名:
Risperidone Maintenance Treatment in Schizophrenia: A Randomized, Controlled Trial
作者: Wang, Chuan-Yue1; Xiang, Yu-Tao; Cai, Zhuo-Ji; Weng, Yong-Zhen; Bo, Qi-Jing; Zhao, Jing-Ping; Liu, Tie-Qiao; Wang, Gao-Hua; Weng, Shi-Min; Zhang, Hong-Yan; Chen, Da-Fang; Tang, Wai-Kwong
刊名: AMERICAN JOURNAL OF PSYCHIATRY
发表日期: 2010-06-01
卷: 167, 期:6, 页:676-685
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: SYNDROME SCALE PANSS ; NORTH-AMERICAN ; 5 DIMENSIONS ; HALOPERIDOL ; THERAPY ; RELAPSE ; RECOMMENDATIONS ; FLUPHENAZINE ; PREVENTION ; DECANOATE
英文摘要:

Objective: Prevention of relapse is the crucial task in the maintenance treatment of schizophrenia. The investigators in this study sought to determine the duration of maintenance treatment needed with the initial therapeutic dose, in contrast to a reduced dose.

Method: In a multicenter open-label, randomized, controlled study, patients with schizophrenia who were clinically stabilized following an acute episode were randomly assigned to a no-dose-reduction group (initial optimal therapeutic dose continued throughout the study), a 4-week group (initial optimal therapeutic dose continued for 4 weeks, followed by a 50% dose reduction that was maintained until the end of the study), or a 26-week group (initial optimal therapeutic dose continued for 26 weeks, followed by a 50% dose reduction until the end of the study). All patients continued until the last recruited patient completed the 1-year follow-up.

Results: Of the 404 patients who met the entry criteria and were randomly assigned, 374 completed the study. The estimated mean time from entry to relapse was 571 days in the 4-week group, 615 days in the 26-week group, and 683 days in the no-dose-reduction group, with estimated relapse rates of 30.5%, 19.5%, and 9.4%, respectively. Patients in the nodose- reduction group experienced greater reduction in the severity of psychotic symptoms.

Conclusions: Patients who continued to receive the full risperidone dose used for their acute episode had fewer relapses than those who had dose reductions after 4 weeks or 26 weeks during the maintenance period. There was negligible difference in side effects among the three groups. (Am J Psychiatry 2010;167:676-685)

语种: 英语
所属项目编号: 2004BA720A22 ; RIS-CN-MCCT-0201
项目资助者: Ministry of Science and Technology Program, People&prime ; s Republic of China ; Research Foundation of Xian-Janssen Pharmaceutical Company
WOS记录号: WOS:000278269500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67870
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Capital Med Univ, Lab Clin Psychopharmacol, Beijing & Hosp, Beijing 100088, Peoples R China
2.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
3.Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha 410083, Peoples R China
4.Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan 430072, Peoples R China
5.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
6.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
7.Peking Univ, Sch Publ Hlth, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Chuan-Yue,Xiang, Yu-Tao,Cai, Zhuo-Ji,et al. Risperidone Maintenance Treatment in Schizophrenia: A Randomized, Controlled Trial[J]. AMERICAN JOURNAL OF PSYCHIATRY,2010,167(6):676-685.
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