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学科主题: 临床医学
题名:
Weight Loss Correlates with Macrophage Inhibitory Cytokine-1 Expression and Might Influence Outcome in Patients with Advanced Esophageal Squamous Cell Carcinoma
作者: Lu, Zhi-Hao1; Yang, Li2; Yu, Jing-Wei1; Lu, Ming1; Li, Jian1; Zhou, Jun1; Wang, Xi-Cheng1; Gong, Ji-Fang1; Gao, Jing1; Zhang, Xiao-Tian1; Li, Jie1; Li, Yan1; Shen, Lin1
关键词: Weight loss ; esophageal SCC ; macrophage inhibitory cytokine-1 ; chemotherapy ; overall survival
刊名: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
发表日期: 2014
DOI: 10.7314/APJCP.2014.15.15.6047
卷: 15, 期:15, 页:6047-6052
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TGF-BETA SUPERFAMILY ; CANCER CACHEXIA ; CONTROLLED-TRIAL ; MIC-1 ; CHEMOTHERAPY ; PLASMA ; SERUM ; PREVALENCE ; PROGNOSIS ; MORTALITY
英文摘要:

Background: Weight loss during chemotherapy has not been exclusively investigated. Macrophage inhibitory cytokine-1 (MIC-1) might play a role in its etiology. Here, we investigated the prognostic value of weight loss before chemotherapy and its relationship with MIC-1 concentration and its occurrence during chemotherapy in patients with advanced esophageal squamous cell carcinoma (ESCC). Materials and Methods: We analyzed 157 inoperable locally advanced or metastatic ESCC patients receiving first-line chemotherapy. Serum MIC-1 concentrations were assessed before chemotherapy. Patients were assigned into two groups according to their weight loss before or during chemotherapy:>5% weight loss group and <= 5% weight loss group. Results: Patients with weight loss>5% before chemotherapy had shorter progression-free survival period (5.8 months vs. 8.7 months; p=0.027) and overall survival (10.8 months vs. 20.0 months; p=0.010). Patients with weight loss >5% during chemotherapy tended to have shorter progression-free survival (6.0 months vs. 8.1 months; p=0.062) and overall survival (8.6 months vs. 18.0 months; p=0.022), and if weight loss was reversed during chemotherapy, survival rates improved. Furthermore, serum MIC-1 concentration was closely related to weight loss before chemotherapy (p=0.001) Conclusions: Weight loss both before and during chemotherapy predicted poor outcome in advanced ESCC patients, and MIC-1 might be involved in the development of weight loss in such patients.

语种: 英语
WOS记录号: WOS:000343723600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67873
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Peking Univ Sch Oncol, Beijing Canc Hosp & Inst, Dept GI Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Zhangzhou, Fujian Province, Peoples R China
2.Zhangzhou Municipal Hosp, Dept Oncol, Zhangzhou, Fujian Province, Peoples R China

Recommended Citation:
Lu, Zhi-Hao,Yang, Li,Yu, Jing-Wei,et al. Weight Loss Correlates with Macrophage Inhibitory Cytokine-1 Expression and Might Influence Outcome in Patients with Advanced Esophageal Squamous Cell Carcinoma[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(15):6047-6052.
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