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学科主题: 公共卫生
题名:
Dual-Modality Monitoring of Tumor Response to Cyclophosphamide Therapy in Mice with Bioluminescence Imaging and Small-Animal Positron Emission Tomography
作者: Ma, Xibo; Liu, Zhaofei; Yang, Xin; Gao, Qiujuan; Zhu, Shouping; Qin, Chenghu; Liu, Kai; Zhang, Bo; Han, Dong; Wang, Fan2; Tian, Jie1
刊名: MOLECULAR IMAGING
发表日期: 2011-07-01
DOI: 10.2310/7290.2010.00041
卷: 10, 期:4, 页:278-283
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Biochemistry & Molecular Biology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; METASTASIS ; INHIBITION ; GROWTH
英文摘要:

The purpose of this study was to noninvasively monitor the therapeutic efficacy of cyclophosphamide (CTX) in a mouse model by dual-modality molecular imaging: positron emission tomography (PET) and bioluminescence imaging (BLI). Firefly luciferase (fLuc) transfected HCC-LM3-fLuc human hepatocellular carcinoma cells were injected subcutaneously into BALB/c nude mice to establish the experimental tumor model. Two groups of HCC-LM3-fLuc tumor-bearing mice (n = 7 per group) were treated with saline or CTX (100 mg/kg on days 0, 2, 5, and 7). BLI and (18)F-fluorodeoxyglucose ((18)F-FDG) PET scans were done to evaluate the treatment efficacy. CTX induced a 25.25 +/- 13.13% and 35.91 +/- 25.85% tumor growth inhibition rate on days 9 and 12 posttreatment, respectively, as determined by BLI. A good linear correlation was found between the tumor sizes measured by caliper and the BLI signals determined by optical imaging (R(2) = .9216). (18)F-FDG imaging revealed a significant uptake reduction in the tumors of the CTX-treated group compared to that in the saline control group (5.30 +/- 1.97 vs 3.00 +/- 2.11% ID/g) on day 16 after CTX treatment. Dual-modality molecular imaging using BLI and small-animal PET can play important roles in the process of chemotherapy and will provide noninvasive and reliable monitoring of the therapeutic response.

语种: 英语
WOS记录号: WOS:000294562600006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67878
Appears in Collections:北京大学医药卫生分析中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Med Image Proc Grp, Inst Automat, Beijing 100190, Peoples R China
2.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
3.Northeastern Univ, Sino Dutch Biomed & Informat Engn Sch, Shenyang, Peoples R China

Recommended Citation:
Ma, Xibo,Liu, Zhaofei,Yang, Xin,et al. Dual-Modality Monitoring of Tumor Response to Cyclophosphamide Therapy in Mice with Bioluminescence Imaging and Small-Animal Positron Emission Tomography[J]. MOLECULAR IMAGING,2011,10(4):278-283.
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