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Preparation and biodistribution of a Tc-99m tricarbonyl complex with deoxyglucose dithiocarbamate as a tumor imaging agent for SPECT
Lin, Xiao1; Chao, Xiaoyu1; Zhang, Junbo1; Jin, Zhonghui2; Zhang, Yanyan2
关键词Tc-99m tricarbonyl complex Tumor imaging agent Deoxyglucose Dithiocarbamate
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2014-08-15
DOI10.1016/j.bmcl.2014.06.037
24期:16页:3964-3967
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fundamental Research Funds for the Central Universities ; Beijing Nova Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fundamental Research Funds for the Central Universities ; Beijing Nova Program
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]BIOLOGICAL EVALUATION ; DERIVATIVES ; THERAPY ; GLUCOSE ; CANCER
英文摘要

The deoxyglucose dithiocarbamate (DGDTC) was successfully labeled with the Tc-99m(CO)(3) core to provide the corresponding Tc-99m(CO)(3)-DGDTC complex in good yields. The radiochemical purity of the Tc-99m(CO)(3)-DGDTC complex was over 90%, as measured by high performance liquid chromatography (HPLC). The complex possessed good stability in saline at room temperature and in mouse plasma at 37 degrees C. Its partition coefficient result indicated that it was a hydrophilic complex. The electrophoresis results showed the complex was neutral. The biodistribution of Tc-99m(CO)(3)-DGDTC in mice bearing S 180 tumor showed that the complex clearly accumulated in tumor, exhibiting high tumor/blood and tumor/muscle ratios and good tumor retention. Single photon emission computed tomography (SPECT) image studies showed there was a visible uptake in tumor sites, suggesting Tc-99m(CO)(3)-DGDTC could be considered as a potential tumor imaging agent. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号21171024 ; 81101069 ; 7112035 ; 105566 ; xxhz201306
资助者National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fundamental Research Funds for the Central Universities ; Beijing Nova Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Fundamental Research Funds for the Central Universities ; Beijing Nova Program
WOS记录号WOS:000340565900056
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67879
专题北京大学第三临床医学院_核医学科
作者单位1.Beijing Normal Univ, Coll Chem, Minist Educ, Key Lab Radiopharmaceut, Beijing 100875, Peoples R China
2.Peking Univ, Hosp 3, Dept Nucl Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Lin, Xiao,Chao, Xiaoyu,Zhang, Junbo,et al. Preparation and biodistribution of a Tc-99m tricarbonyl complex with deoxyglucose dithiocarbamate as a tumor imaging agent for SPECT[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(16):3964-3967.
APA Lin, Xiao,Chao, Xiaoyu,Zhang, Junbo,Jin, Zhonghui,&Zhang, Yanyan.(2014).Preparation and biodistribution of a Tc-99m tricarbonyl complex with deoxyglucose dithiocarbamate as a tumor imaging agent for SPECT.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(16),3964-3967.
MLA Lin, Xiao,et al."Preparation and biodistribution of a Tc-99m tricarbonyl complex with deoxyglucose dithiocarbamate as a tumor imaging agent for SPECT".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.16(2014):3964-3967.
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