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学科主题: 基础医学
题名:
GLB prevents tumor metastasis of Lewis lung carcinoma by inhibiting tumor adhesion actions′
作者: Pan, Y; Song, QL; Lin, YH; Lu, N; Yu, HM; Li, XJ
关键词: neoplasm metastasis ; adhesions ; carcinoma ; Lewis lung
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2005-07-01
DOI: 10.1111/j.1745-7254.2005.00125.x
卷: 26, 期:7, 页:881-886
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CELL ADHESION ; IN-VITRO ; ENDOTHELIAL-CELLS ; CANCER-CELLS ; EXPRESSION ; MICE ; MIGRATION ; ANTITUMOR ; GROWTH
英文摘要:

Aim: To investigate the inhibitory effect of a new compound of GLB on tumor metastasis in vivo and analyze its actions on tumor cell adhesion to clarify its mechanism. Methods: The effect of GLB on tumor metastasis was analyzed by Lewis lung carcinoma model. The pathological morphology of lung alveolar was evaluated by hematoxylin-eosin staining. The effect of GLB on the proliferation of human prostate cancer cell (PC-3M, with a high metastatic characteristic) was studied using tire MTT method, and its actions on PC-3M cell adhesion to human umbilical vein endothelial cells (HUVEC) and laminin were analyzed in vitro. Results: GLB (100 mg center dot kg(-1)center dot d(-1) for 28 d, ig) reduced the number of lung colonies of Lewis lung carcinoma metastasis significantly (P<0.05). Simultaneously, GLB could mitigate the damage of lung alveolar caused by metastasic tumor deposits. In vitro, GLB inhibited dramatically the adhesion of PC-3M cells to HUVEC (P< 0.01) and laminin (P<0.05), without cytotoxic or anti-proliferative action on PC-3M cells. Conclusion: GLB has anti-tumor metastatic activity, which partly depends on its inhibition of tumor adhesion.

语种: 英语
WOS记录号: WOS:000230442400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/67880
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat Bioorgan Drugs, Beijing 100083, Peoples R China
3.Natl Res Inst Family Planning, Beijing 100081, Peoples R China

Recommended Citation:
Pan, Y,Song, QL,Lin, YH,et al. GLB prevents tumor metastasis of Lewis lung carcinoma by inhibiting tumor adhesion actions&prime;[J]. ACTA PHARMACOLOGICA SINICA,2005,26(7):881-886.
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