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学科主题基础医学
GLB prevents tumor metastasis of Lewis lung carcinoma by inhibiting tumor adhesion actions′
Pan, Y; Song, QL; Lin, YH; Lu, N; Yu, HM; Li, XJ
关键词neoplasm metastasis adhesions carcinoma Lewis lung
刊名ACTA PHARMACOLOGICA SINICA
2005-07-01
DOI10.1111/j.1745-7254.2005.00125.x
26期:7页:881-886
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CELL ADHESION ; IN-VITRO ; ENDOTHELIAL-CELLS ; CANCER-CELLS ; EXPRESSION ; MICE ; MIGRATION ; ANTITUMOR ; GROWTH
英文摘要

Aim: To investigate the inhibitory effect of a new compound of GLB on tumor metastasis in vivo and analyze its actions on tumor cell adhesion to clarify its mechanism. Methods: The effect of GLB on tumor metastasis was analyzed by Lewis lung carcinoma model. The pathological morphology of lung alveolar was evaluated by hematoxylin-eosin staining. The effect of GLB on the proliferation of human prostate cancer cell (PC-3M, with a high metastatic characteristic) was studied using tire MTT method, and its actions on PC-3M cell adhesion to human umbilical vein endothelial cells (HUVEC) and laminin were analyzed in vitro. Results: GLB (100 mg center dot kg(-1)center dot d(-1) for 28 d, ig) reduced the number of lung colonies of Lewis lung carcinoma metastasis significantly (P<0.05). Simultaneously, GLB could mitigate the damage of lung alveolar caused by metastasic tumor deposits. In vitro, GLB inhibited dramatically the adhesion of PC-3M cells to HUVEC (P< 0.01) and laminin (P<0.05), without cytotoxic or anti-proliferative action on PC-3M cells. Conclusion: GLB has anti-tumor metastatic activity, which partly depends on its inhibition of tumor adhesion.

语种英语
WOS记录号WOS:000230442400016
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/67880
专题基础医学院_药理学系
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat Bioorgan Drugs, Beijing 100083, Peoples R China
3.Natl Res Inst Family Planning, Beijing 100081, Peoples R China
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Pan, Y,Song, QL,Lin, YH,et al. GLB prevents tumor metastasis of Lewis lung carcinoma by inhibiting tumor adhesion actions&prime;[J]. ACTA PHARMACOLOGICA SINICA,2005,26(7):881-886.
APA Pan, Y,Song, QL,Lin, YH,Lu, N,Yu, HM,&Li, XJ.(2005).GLB prevents tumor metastasis of Lewis lung carcinoma by inhibiting tumor adhesion actions′.ACTA PHARMACOLOGICA SINICA,26(7),881-886.
MLA Pan, Y,et al."GLB prevents tumor metastasis of Lewis lung carcinoma by inhibiting tumor adhesion actions′".ACTA PHARMACOLOGICA SINICA 26.7(2005):881-886.
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